Scientific publications

Great progress has been made in the first five years of the project as shown by the total of 219 publications up until December 2016. The ADITEC publications were cited >3,600 times and the citation impact is almost 3 times the average citation impact of all Web of Science papers published in “Immunology” area in the time range 2012-2016 (5.09). 

The total impact factor is 1.565 with an average JIF for paper = 7,45  and 69% of papers have been published in journals with impact factors in Quartile 1 of their respective subject categories.

See below for a complete list of publications

 

Publications in 2016

Human isotype-dependent inhibitory antibody responses against Mycobacterium tuberculosis. 
Zimmermann, N; Thormann, V; Hu, B; Kohler, AB; Imai-Matsushima, A; Locht, C; Arnett, E; Schlesinger, LS; Zoller, T; Schurmann, M; Kaufmann, SHE; Wardemann, H, EMBO Molecular Medicine (2016) doi: 10.15252/emmm.201606330

Anticipating policy considerations for a future HIV vaccine: a preliminary study.
Williams, EA; Lewis, DJM; Bertholet, S; Zazzi, M.  Vaccine (2016) doi: 10.1016/j.vaccine.2016.03.086

Circulating Gut-Homing (alpha(4)beta(+)(7)) Plasmablast Responses against Shigella Surface Protein Antigens among Hospitalized Patients with Diarrhea.
Sinha, A; Dey, A; Saletti, G; Samanta, P; Chakraborty, PS; Bhattacharya, MK; Ghosh, S; Ramamurthy, T; Kim, JO; Yang, JS; Kim, DW; Czerkinsky, C; Nandy, RK. Clinical and Vaccine Immunology (2016) doi: 10.1128/CVI.00205-16

Mucosal BCG vaccination induces protective lung resident memory T cell populations against Tuberculosis.
Perdomo C. Zedler U., kuhl A, Lozza L, Saikali P, Sander L, Vogelzang A, Kaufmann S,  Kupz A. American Society for Microbiology (2016)  November doi: 10.1128/mBio.01686-16

KLRG1 and PD-1 expression are increased on T-cells following tuberculosis-treatment and identify cells with different proliferative capacities in BCG-vaccinated adults.
Boer, MC; van Meijgaarden, KE; Goletti, D; Vanini, V; Prins, C; Ottenhoff, THM; Joosten, SA. Tuberculosis (2016) doi: 10.1016/j.tube.2015.11.008.

Impairment of CCR6+ and CXCR3+ Th Cell migration in HIV-1 infection is rescued by modulating actin polymerization.
Cecchinato V, Bernasconi E, Speck R, Proietti M, Sauermann U, D’Agostino G, denelon G, Rezzonico Jost T, Grassi F, Raeli L, Schoeni-Affolter F, Stahl-Hennig C, Uguccioni M. Journal of Immunology (2016) doi: 10.4049/jimmunol.16005688

High-throughput and computational approaches for diagnostic and prognostic host tuberculosis biomarkers.
January Weiner and Stefan H.E. Kaufmann. International Journal of Infectious Diseases (2016), dx.doi.org/10.1016/j.ijid.2016.10.017.

Novel approaches to TB vaccine development.
Stefan H.E. Kaufmann, January Weiner, C. Fordham von Reyn. International Journal of Infectious Diseases (2016), dx.doi.org/10.1016/j.ijid.2016.10.018.

Expression and function of IL-1R8 (TIR8/SIGIRR): a regulatory member of the IL-1 receptor family in platelets.
Anselmo A, Riva F, Gentile S, Soldani C, Barbagallo M, Mazzon C, Feruglio F, Polentarutti N, Somma P, Carullo P, Angelini C, Bacci M, Mendolicchio GL, Voza A, Nebuloni M, Mantovani A, Garlanda C. Cardiovasc Res. 2016 Sep;111(4):373-84.

Intramuscular Immunisation with Chlamydial Proteins Induces Chlamydia trachomatis Specific Ocular Antibodies.
Alexander Badamchi-Zadeh, Paul F McKay, Martin J Holland, Wayne Paes, Andrzej Brzozowski, Charles Lacey, Frank Follmann, John S Tregoning, Robin J Shattock. PloS One 2015.

A Multi-Component Prime-Boost Vaccination Regimen with a Consensus MOMP Antigen Enhances Chlamydia trachomatis Clearanc.
Badamchi-Zadeh A, McKay PF, Korber BT, et al. Frontiers in immunology 2016; 7: 162.

Multicriteria decision analysis and core values for enhancing vaccine-related decision-making.
Badamchi-Zadeh A, McKay PF, Korber BT, et al. A4. Barocchi Michèle A., Black Steve, Rappuoli Rino. Science Translational Medicine (2016) June 29 doiI: 10.1126/scitranslmed.aaf0756.

Testing the H56 Vaccine Delivered in 4 Different Adjuvants as a BCG-Booster in a Non-Human Primate Model of Tuberculosis.
Billeskov R, Tan EV, Cang M, Abalos RM, Burgos J, Pedersen BV, Christensen D, Agger EM, Andersen P.  PLoS One. 2016 Aug 15;11(8):e0161217. doi: 10.1371/journal.pone.0161217. eCollection 2016.

Vascular pentraxin 3 controls arterial thrombosis by targeting collagen and fibrinogen induced platelets aggregation.
Bonacina F, Barbieri SS, Cutuli L, Amadio P, Doni A, Sironi M, Tartari S, Mantovani A, Bottazzi B, Garlanda C, Tremoli E, Catapano AL, Norata GD. Biochim Biophys Acta. 2016, 1862:1182-90. doi: 10.1016/j.bbadis.2016.03.007. PubMed PMID: 26976330.

The pentraxins PTX3 and SAP in innate immunity, regulation of inflammation and tissue remodelling.
Bottazzi B, Inforzato A, Messa M, Barbagallo M, Magrini E, Garlanda C, Mantovani A. J Hepatol. 2016, 64:1416-1427. doi: 10.1016/j.jhep.2016.02.029.. PubMed PMID: 26921689.

Vaccine-induced TH17 cells are established as resident memory cells in the lung and promote local IgA responses.
Christensen D, Mortensen R, Rosenkrands I, Dietrich J, Andersen P. Mucosal Immnology. (2016) April 6;  doi: 10.1038/mi.2016.28

Modulation of Primary immune response by Different Vaccine adjuvants
Annalisa Ciabattini1*, Elena Pettini1, Fabio Fiorino1, Gabiria Pastore1, Peter Andersen2, Gianni Pozzi1 and Donata Medaglini1*

Neutropenia as an Adverse Event following Vaccination: Results from Randomized Clinical Trials in Healthy Adults and Systematic Review
Muturi-Kioi et al._PLoS ONE 2016

ESAT-6-dependent cytosolic pattern recognition is essential for non-cognate, IL-18-driven, IFN-γ-mediated in vivo control of tuberculosis.
Kupz, A., U. Zedler, M. Stäber, C. Perdomo, A. Dorhoi, R. Brosch, S.H.E. Kaufmann
J Clin Invest. 2016. doi:10.1172/JCI84978.

Evaluation of polylactic acid nanoparticles safety using Drosophila model.
Legaz S, Exposito JY, Lethias C, Viginier B, Terzian C, Verrier B.
Nanotoxicology. 2016 Oct;10(8):1136-43. doi: 10.1080/17435390.2016.1181806. Epub 2016 May 16.

Booster vaccination against tetanus and diphtheria: insufficient protection against diphtheria in young and elderly adults.
Grasse M, Meryk A, Schirmer M, Grubeck-Loebenstein B, Weinberger 1.
Immun Ageing. 2016 Sep 5;13(1):26. eCollection 2016.

Deletion of nuoG from the Vaccine Candidate Mycobacterium bovis BCG ΔureC::hly Improves Protection against Tuberculosis.
Gengenbacher M1, Nieuwenhuizen N2, Vogelzang A2, Liu H2, Kaiser P2, Schuerer S, Lazar D, Wagner I, Mollenkopf HJ, Kaufmann SH.
MBio. 2016 May 24;7(3). pii: e00679-16.

Trehalose diester glycolipids are superior to the monoesters in binding to Mincle, activation of macrophages in vitro and adjuvant activity in vivo.
Huber A, Kallerup RS, Korsholm KS, Franzyk H, Lepenies B, Christensen D, Foged C, Lang R.
Innate Immun. 2016 Aug;22(6):405-18.

Fluid phase recognition molecules in neutrophil-dependent immune responses.
Jaillon S, Ponzetta A, Magrini E, Barajon I, Barbagallo M, Garlanda C, Mantovani A.
Semin Immunol. 2016 Apr;28(2):109-18.

Patients with Tuberculosis Have a Dysfunctional Circulating B-Cell Compartment, Which Normalizes following Successful Treatment.
Joosten SA, van Meijgaarden KE, Del Nonno F, Baiocchini A, Petrone L, Vanini V, Smits HH, Palmieri F, Goletti D, Ottenhoff TH.
PLoS Pathog. 2016 Jun 15;12(6):e1005687.

Non‐glycosidic compounds can stimulate both human and mouse iNKT cells.
John‐Paul Jukes, Uzi Gileadi, Hemza Ghadbane, Ting‐Fong Yu, Dawn Shepherd, Liam R. Cox, Gurdyal S. Besra, 2 and Vincenzo Cerundolo
Eur J Immunol. 2016 May; 46(5): 1224–1234.

TB biomarkers, TB correlates and human challenge models: New tools for improving assessment of new TB vaccines.
Kaufmann SH, Fortune S, Pepponi I, Ruhwald M, Schrager LK, Ottenhoff TH.
Tuberculosis (Edinb). 2016 Aug;99 Suppl 1:S8-S11.

A Mouse Model of Latent Tuberculosis Infection to Study Intervention Strategies to Prevent Reactivation
Andreas Kupz, Ulrike Zedler, Manuela Stäber and Stefan H. E. Kaufmann.
PLoS One. 2016; 11(7): e0158849.

DNA Vaccines Encoding Antigen Targeted to MHC Class II Induce Influenza-Specific CD8(+) T Cell Responses, Enabling Faster Resolution of Influenza Disease.
Lambert L, Kinnear E, McDonald JU, Grodeland G, Bogen B, Stubsrud E, Lindeberg MM, Fredriksen AB, Tregoning JS.
Front Immunol. 2016 Aug 23;7:321.

Directing vaccine immune responses to mucosa by nanosized particulate carriers encapsulating NOD ligands.
Pavot V, Climent N, Rochereau N, Garcia F, Genin C, Tiraby G, Vernejoul F, Perouzel E, Lioux T, Verrier B, Paul S.
Biomaterials. 2016 Jan;75:327-39.

Modulation of Chemokine Responses: Synergy and Cooperativity.
Proudfoot AE, Uguccioni M.
Front Immunol. 2016 May 19;7:183.

Aging of the immune system: Focus on inflammation and vaccination.
Pinti M, Appay V, Campisi J, Frasca D, Fülöp T, Sauce D, Larbi A, Weinberger B, Cossarizza A.
Eur J Immunol. 2016 Oct;46(10):2286-2301.

CD8(+) T cells of Listeria monocytogenes-infected mice recognize both linear and spliced proteasome products.
Platteel AC, Mishto M, Textoris-Taube K, Keller C, Liepe J, Busch DH, Kloetzel PM, Sijts AJ.
Eur J Immunol. 2016 May;46(5):1109-18.

Strategies to enhance immunogenicity of cDNA vaccine encoded antigens by modulation of antigen processing.
Platteel AC, Marit de Groot A, Keller C, Andersen P, Ovaa H, Kloetzel PM, Mishto M, Sijts AJ.
Vaccine. 2016 Sep 30;34(42):5132-40.

Use of the Microparticle Nanoscale Silicon Dioxide as an Adjuvant To Boost Vaccine Immune Responses against Influenza Virus in Neonatal Mice.
Russell RF, McDonald JU, Lambert L, Tregoning JS.
J Virol. 2016 Apr 14;90(9):4735-44.

Triggering Intracellular Receptors for Vaccine Adjuvantation.
Gutjahr A, Tiraby G, Perouzel E, Verrier B, Paul S.
Trends Immunol. 2016 Sep;37(9):573-87.

The Effect of Cellular Stress on T and B Cell Memory Pathways in Immunized and Unimmunized BALB/c Mice.
Wang Y, Rahman D, Mistry M, Lehner T.
J Biol Chem. 2016 Sep 23;291(39):20707-17.

Adult vaccination against tetanus and diphtheria: the European perspective.
Weinberger B.
Clin Exp Immunol. 2016 Jun 9.

Subunit vaccine H56/CAF01 induces a population of circulating CD4 T cells that traffic into the Mycobacterium tuberculosis-infected lung.
Woodworth JS, Cohen SB, Moguche AO, Plumlee CR, Agger EM, Urdahl KB, Andersen P.
Mucosal Immunol. 2016 Aug 24.

Syndecans promote mycobacterial internalization by lung epithelial cells.
Zimmermann N, Saiga H, Houthuys E, Moura-Alves P, Koehler A, Bandermann S, Dorhoi A, Kaufmann SH.
Cell Microbiol. 2016 Dec;18(12):1846-1856.

A blood RNA signature for tuberculosis disease risk: a prospective cohort study.
Zak DE, Penn-Nicholson A, Scriba TJ, Thompson E, Suliman S, Amon LM, Mahomed H, Erasmus M, Whatney W, Hussey GD, Abrahams D, Kafaar F, Hawkridge T, Verver S, Hughes EJ, Ota M, Sutherland J, Howe R, Dockrell HM, Boom WH, Thiel B, Ottenhoff TH, Mayanja-Kizza H, Crampin AC, Downing K, Hatherill M, Valvo J, Shankar S, Parida SK, Kaufmann SH, Walzl G, Aderem A, Hanekom WA; ACS and GC6-74 cohort study groups.
Lancet. 2016 Mar 23. pii: S0140-6736(15)01316-1. doi: 10.1016/S0140-6736(15)01316-1.

Vaccine-induced Th17 cells are established as resident memory cells in the lung and promote local IgA responses.
Mucosal Immunol. 2016 Apr 6. doi: 10.1038/mi.2016.28.
Christensen D, Mortensen R, Rosenkrands I, Dietrich J, Andersen P.

Vaccination in early life: standing up to the challenges
Elodie Mohr, Claire-Anne Siegrist
Opinion in Immunology, Volume 41, August 2016, Pages 1–8 doi:10.1016/j.coi.2016.04.004

Reverse vaccinology 2.0: Human immunology instructs vaccine antigen design.
Rappuoli R, Bottomley MJ, D'Oro U, Finco O, De Gregorio E.
J Exp Med. 2016 Apr 4;213(4):469-81. doi: 10.1084/jem.20151960. Epub 2016 Mar 28.

Molecular Determinants in Phagocyte-Bacteria Interactions.
Kaufmann SH, Dorhoi A.
Immunity. 2016 Mar 15;44(3):476-91. doi: 10.1016/j.immuni.2016.02.014.

Pathology and immune reactivity: understanding multidimensionality in pulmonary tuberculosis.
Dorhoi A, Kaufmann SH.
Semin Immunopathol. 2016 Mar;38(2):153-66. doi: 10.1007/s00281-015-0531-3. Epub 2015 Oct 5.

Systems vaccinology informs influenza vaccine immunogenicity.
García-Sastre A.
Proc Natl Acad Sci U S A. 2016 Feb 16;113(7):1689-91. doi: 10.1073/pnas.1525361113. Epub 2016 Feb 3.

Reprogramming the T Cell Response to Tuberculosis
Joshua S. Woodworth, Peter Andersen
Cell, DOI: http://dx.doi.org/10.1016/j.it.2015.12.009

Human Circulating Antibody-Producing B Cell as a Predictive Measure of Mucosal Immunity to Poliovirus.
Dey A, Molodecky NA, Verma H, Sharma P, Yang JS, Saletti G, Ahmad M, Bahl SK, Wierzba TF, Nandy RK, Deshpande JM, Sutter RW, Czerkinsky C.
PLoS One. 2016 Jan 5;11(1):e0146010. doi: 10.1371/journal.pone.0146010. eCollection 2016.

Different human vaccine adjuvants promote distinct antigen-independent immunological signatures tailored to different pathogens
Niels Peter H. Knudsen, Anja Olsen, Cecilia Buonsanti, Frank Follmann, Yuan Zhang, Rhea N. Coler, Christopher B. Fox, Andreas Meinke, Ugo D´Oro, Daniele Casini, Alessandra Bonci, Rolf Billeskov, Ennio De Gregorio, Rino Rappuoli, Ali M. Harandi, Peter Andersen & Else Marie Agger
Nature Scientific Reports 21 January 2016, doi:10.1038/srep19570

Systems biology of immunity to MF59-adjuvanted versus non-adjuvanted trivalent seasonal influenza vaccines in early childhood
Helder I Nakaya, Elizabetth Clutterbuck, Dmitri Kazmin, Lili Wang, Mario Cortese, Steven E Bosinger, Nirav B, Patel, Daniel E Zak, Alan Aderem, Tao Dong, Giuseppe Del Giudice, Rino Rappuoli , Vincenzo Cerundolo, Andrew J Pollard, Bali Pulendran, Claire-Anne Siegrist
Proc Natl Acad Sci U S A. January 11, 2016, doi: 10.1073/pnas.1519690113

 

Publications in 2015

T cell immunity. Functional heterogeneity of human memory CD4⁺ T cell clones primed by pathogens or vaccines.
Becattini S, Latorre D, Mele F, Foglierini M, De Gregorio C, Cassotta A, Fernandez B, Kelderman S, Schumacher TN, Corti D, Lanzavecchia A, Sallusto F.
Science. 2015 Jan 23;347(6220):400-6. doi: 10.1126/science.1260668. Epub 2014 Dec 4.

Chemokine interaction with synergy-inducing molecules: fine tuning modulation of cell trafficking.
Cecchinato V, D'Agostino G, Raeli L, Uguccioni M.
J Leukoc Biol. 2015 Dec 29. pii: jlb.1MR1015-457R.

Intramuscular Priming and Intranasal Boosting Induce Strong Genital Immunity Through Secretory IgA in Minipigs Infected with Chlamydia trachomatis.
Lorenzen E, Follmann F, Bøje S, Erneholm K, Olsen AW, Agerholm JS, Jungersen G, Andersen P.
Front Immunol. 2015 Dec 16;6:628. doi: 10.3389/fimmu.2015.00628. eCollection 2015.

Novel adjuvant formulations for delivery of anti-tuberculosis vaccine candidates.
Agger EM.
Adv Drug Deliv Rev. 2015 Nov 17. pii: S0169-409X(15)00276-8. doi: 10.1016/j.addr.2015.11.012. [Epub ahead of print]

Micelle-Based Adjuvants for Subunit Vaccine Delivery.
Trimaille T, Verrier B.
Vaccines (Basel). 2015 Sep 25;3(4):803-13.

TB vaccines; promoting rapid and durable protection in the lung.
Andersen P, Urdahl K.
Curr Opin Immunol. (2015) August; 35:55-62. doi: 10.1016/j.coi.2015.06.001.

A multi-subunit Chlamydia vaccine inducing neutralizing antibodies and strong IFN-g+ CMI responses protects against a genital infection in minipigs.
Bøje S, Olsen AW, Erneholm K, Agerholm J S, Jungersen G, Andersen P, Follmann F.
Immunology and Cell Biology (2015) August 13; doi: 10.1038/icb.2015.79.

Retinoic Acid Promotes Mucosal and Systemic Immune  Responses after Mucosal Priming and Systemic Boosting in Mice.
Cirelli E, Riccomi A, Veglia F, Gesa V, De Magistris MT, et al.
J Vaccines  6: 265. (2015) January 20; doi:10.4172/2157-7560.1000265.  

Focused human gene expression profiling using dual-color reverse transcriptase multiplex ligation-dependent probe amplification (dcRT-MLPA).
Haks MC, Goeman JJ, Magis-Escurra C and Ottenhoff THM. 
Vaccine (2015) April 24;pii:S0264-410X(15)00518-6.doi: 0.1016/j.vaccine.2015.04.054.

A purified truncated form of yeast Gal4 expressed in Escherichia coli and used to functionalize poly(lactic acid) nanoparticle surface is transcriptionally active in cellulo.
Legaz S, Exposito JY, Borel A, Candusso MP, Megy S, Montserret R, Lahaye V, Terzian C, Verrier B.
Protein Expr Purif (2015) September; 113:94-101. doi: 10.1016/j.pep.2015.05.009.

An acidic microenvironment sets the humoral pattern recognition molecule PTX3 in  a tissue repair mode.
Doni A, Musso T, Morone D, Bastone A, Zambelli V, Sironi M, Castagnoli C, Cambieri I, Stravalaci M, Pasqualini F, Laface I, Valentino S, Tartari S, Ponzetta A, Maina V, Barbieri SS,Tremoli E, Catapano AL, Norata GD, Bottazzi B, Garlanda C, Mantovani A.
J Exp Med. (2015) January 1; 212(6):905-25. doi: 10.1084/jem.20141268 . 

High-throughput data analysis and data integration for vaccine trials
Weiner J 3rd, Kaufmann SH, Maertzdorf J.
Vaccine. 2015 Sep 29;33(40):5249-55. doi: 10.1016/j.vaccine.2015.04.096. Epub 2015 May 11.

Systems integration of innate and adaptive immunity.
Zak DE, Aderem A.
Front Immunol. 2015 Aug 28;6:430. doi: 10.3389/fimmu.2015.00430. eCollection 2015.
Vaccine. 2015 Sep 29;33(40):5241-8. doi: 10.1016/j.vaccine.2015.05.098. Epub 2015 Jun 21.

Epigenetics and Proteomics Join Transcriptomics in the Quest for Tuberculosis Biomarkers
Maria M. Esterhuyse, January Weiner 3rd, Etienne Caron, Andre G. Loxton, Marco Iannaccone, Chandre Wagman, Philippe Saikali, Kim Stanley, Witold E. Wolski, Hans-Joachim Mollenkopf, Matthias Schick, Ruedi Aebersold, Heinz Linhart, Gerhard Walzl, Stefan H. E. Kaufmann
doi: 10.1128/mBio.01187-15, 15 September 2015 mBio vol. 6 no. 5 e01187-15

Partial Attenuation of Respiratory Syncytial Virus with a Deletion of a Small Hydrophobic Gene Is Associated with Elevated Interleukin-1β Responses.
Russell RF, McDonald JU, Ivanova M, Zhong Z, Bukreyev A, Tregoning JS.
J Virol. 2015 Sep 1;89(17):8974-81. doi: 10.1128/JVI.01070-15. Epub 2015 Jun 17.

Peptide-specific T helper cells identified by MHC class II tetramers differentiate into several subtypes upon immunization with CAF01 adjuvanted H56 tuberculosis vaccine formulation.
Prota G, Christensen D, Andersen P, Medaglini D, Ciabattini A
Vaccine. 2015 Nov 27;33(48):6823-30. doi: 10.1016/j.vaccine.2015.09.024. Epub 2015 Oct 20.

Characterization of the Antigen-Specific CD4+ T Cell Response Induced by Prime-Boost Strategies with CAF01 and CpG Adjuvants Administered by the Intranasal and Subcutaneous Routes
Ciabattini A, Prota A, Christensen D, Andersen A, Pozzi G, and Medaglini D.
Front Immunol. 2015; 6: 430. Published online 2015 Aug 28. doi:  10.3389/fimmu.2015.00430. PMCID: PMC4551867

A Stochastic Model for CD4+ T Cell Proliferation and Dissemination Network in Primary Immune Response.
Boianelli A1, Pettini E2, Prota G2, Medaglini D2, Vicino A3.
PLoS One. 2015 Aug 24;10(8):e0135787. doi: 10.1371/journal.pone.0135787. eCollection 2015.

A new TLR2 agonist promotes cross-presentation by mouse and human antigen presenting cells.
Santone M1, Aprea S, Wu TY, Cooke MP, Mbow ML, Valiante NM, Rush JS, Dougan S, Avalos A, Ploegh H, De Gregorio E, Buonsanti C, D'Oro U.
Hum Vaccin Immunother. 2015 Aug 3;11(8):2038-50. doi: 10.1080/21645515.2015.1027467.

Molecular signatures of vaccine adjuvants.
Olafsdottir T, Lindqvist M, Harandi AM.
Vaccine. 2015 May 16. pii: S0264-410X(15)00596-4. doi: 10.1016/j.vaccine.2015.04.099. [Epub ahead of print]

MF59 Mediates Its B Cell Adjuvanticity by Promoting T Follicular Helper Cells and Thus Germinal Center Responses in Adult and Early Life.
Mastelic Gavillet B, Eberhardt CS, Auderset F, Castellino F, Seubert A, Tregoning JS, Lambert PH, de Gregorio E, Del Giudice G, Siegrist CA.J Immunol. 2015 May 15;194(10):4836-45. doi: 10.4049/jimmunol.1402071. Epub 2015 Apr 13.

The stimulatory effect of the TLR4-mediated adjuvant glucopyranosyl lipid A is well preserved in old age.
Weinberger B, Joos C, Reed SG, Coler R, Grubeck-Loebenstein B.
Biogerontology. 2015 May 9. [Epub ahead of print]

Stress activated DC induce dual IL-15 and IL1 mediated pathways, which may elicit CD4+ memory T cells and IFN stimulated genes
Wang Y,Lavender P,Watson J,Arno M1,Lehner T.
J Biol Chem. 2015 Apr 23  doi:10.1074/jbc.M115.645754.

Human CD8 T lymphocytes recognize Mycobacterium tuberculosis antigens presented by HLA-E during active tuberculosis and express type 2 cytokines.
Caccamo N, Pietra G, Sullivan LC, Brooks AG, Prezzemolo T, La Manna MP, Di Liberto D, Joosten SA, van Meijgaarden KE, Di Carlo P, Titone L, Moretta L, Mingari MC, Ottenhoff TH, Dieli F.
Eur J Immunol. 2015 Apr;45(4):1069-81. doi: 10.1002/eji.201445193. Epub 2015 Feb 17.

Human CD8+ T-cells recognizing peptides from Mycobacterium tuberculosis (Mtb) presented by HLA-E have an unorthodox Th2-like, multifunctional, Mtb inhibitory phenotype and represent a novel human T-cell subset.
van Meijgaarden KE, Haks MC, Caccamo N, Dieli F, Ottenhoff TH, Joosten SA.
PLoS Pathog. 2015 Mar 24;11(3):e1004671. doi: 10.1371/journal.ppat.1004671. eCollection 2015.

Recognition of Neisseria meningitidis by the Long Pentraxin PTX3 and Its Role as an Endogenous Adjuvant
Barbara Bottazzi, Laura Santini, Silvana Savino, Marzia M. Giuliani, Ana I. Dueñas Díez, Giuseppe Mancuso, Concetta Beninati, Marina Sironi, Sonia Valentino, Livija Deban, Cecilia Garlanda, Giuseppe Teti, Mariagrazia Pizza, Rino Rappuoli, and Alberto Mantovani
PLoS One. 2015; 10(3): e0120807. Published online 2015 Mar 18. doi:  10.1371/journal.pone.0120807 PMCID: PMC4364741

Plasma cell numbers decrease in bone marrow of old patients.
Pritz T, Lair J, Ban M, Keller M, Weinberger B, Krismer M, Grubeck-Loebenstein B.
Eur J Immunol. 2015 Mar;45(3):738-46. doi: 10.1002/eji.201444878. Epub 2014 Dec 23.

PTX3 is an extrinsic oncosuppressor regulating complement-dependent inflammation in cancer.
Bonavita E, Gentile S, Rubino M, Maina V, Papait R, Kunderfranco P, Greco C, Feruglio F, Molgora M, Laface I, Tartari S, Doni A, Pasqualini F, Barbati E, Basso G, Galdiero MR, Nebuloni M, Roncalli M, Colombo P, Laghi L, Lambris JD, Jaillon S, Garlanda C, Mantovani A.
Cell. 2015 Feb 12;160(4):700-14. doi: 10.1016/j.cell.2015.01.004.

The C-Type Lectin Receptor CLECSF8/CLEC4D Is a Key Component of Anti-Mycobacterial Immunity
Gillian J. Wilson, Mohlopheni J. Marakalala, Jennifer C. Hoving, Arjan van Laarhoven, Rebecca A. Drummond, Bernhard Kerscher, Roanne Keeton, Esther van de Vosse, Tom H.M. Ottenhoff, Theo S. Plantinga, Bachti Alisjahbana, Dhirendra Govender, Gurdyal S. Besra, Mihai G. Netea, Delyth M. Reid, Janet A. Willment, Muazzam Jacobs, Sho Yamasaki, Reinout van Crevel and Gordon D. Brown
Cell Host Microbe. 2015 Feb 11; 17(2): 252–259. doi:  10.1016/j.chom.2015.01.004 PMCID: PMC4334100

Dectin-1 co-activation of neonatal DCs corrects TLR-dependent TH1 deficiency.Lemoine S, et alJ Allerg Clin Immunol.  2015, doi:10.1016/j.jaci.2015.02.030

Preparation and in vitro evaluation of imiquimod loaded polylactide-based micelles as potential vaccine adjuvants.
Jiménez-Sánchez G, Pavot V, Chane-Haong C, Handké N, Terrat C, Gigmes D, Trimaille T, Verrier B.
Pharm Res. 2015 Jan;32(1):311-20. doi: 10.1007/s11095-014-1465-5. Epub 2014 Sep 24.

Autotransporter-based antigen display in bacterial ghosts.
Hjelm A, Söderström B, Vikström D, Jong WS, Luirink J, de Gier JW.Appl Environ Microbiol. 2015 Jan;81(2):726-35. doi: 10.1128/AEM.02733-14. Epub 2014 Nov 14.

Short-term high-fat diet increases macrophage markers in skeletal muscle accompanied by impaired insulin signalling in healthy male subjects.
Boon MR, Bakker LE, Haks MC, Quinten E, Schaart G, Van Beek L, Wang Y, Van Schinkel L, Van Harmelen V, Meinders AE, Ottenhoff TH, Van Dijk KW, Guigas B, Jazet IM, Rensen PC.
Clin Sci (Lond). 2015 Jan;128(2):143-51. doi: 10.1042/CS20140179.

Dysregulation of Apoptosis Is a Risk Factor for Tuberculosis Disease Progression
Thomas O. J. P. Elliott1, Olumuyiwa Owolabi, Simon Donkor, Beate Kampmann, Philip C. Hill, Tom H. M. Ottenhoff, Marielle C. Haks, Stefan H. E. Kaufmann, Jeroen Maertzdorf and Jayne S. Sutherland
J Infect Dis. (2015) doi: 10.1093/infdis/jiv238 

Differential transcriptomic and metabolic profiles of M. africanum- and M. tuberculosis-infected patients after, but not before, drug treatment.
Tientcheu LD, Maertzdorf J, Weiner J, Adetifa IM, Mollenkopf HJ, Sutherland JS, Donkor S, Kampmann B, Kaufmann SH, Dockrell HM, Ota MO.
Genes Immun. 2015 Jun 4. doi: 10.1038/gene.2015.21. [Epub ahead of print]

Molecular signatures for vaccine development.
Maertzdorf J, Kaufmann SH, Weiner J.
Vaccine. 2015 Apr 6. pii: S0264-410X(15)00394-1. doi: 10.1016/j.vaccine.2015.03.075. [Epub ahead of print]

WHO consultation on clinical evaluation of vaccines, 17-18 July 2014, WHO Headquarters, Geneva, Switzerland.
Knezevic I, Moorthy V, Sheets R.
Vaccine. 2015 Apr 21;33(17):1999-2003. doi: 10.1016/j.vaccine.2015.01.056. Epub 2015 Mar 4.

Protein Energy Malnutrition during Vaccination Has Limited Influence on Vaccine Efficacy but Abolishes Immunity if Administered during Mycobacterium tuberculosis Infection.
Truc Hoang, Else Marie Agger, Joseph P Cassidy, Jan P Christensen, Peter Andersen
Infect Immun 2015 May 9;83(5):2118-26. Epub 2015 Mar 9.

Protection Against Chlamydia trachomatis Infection and Upper Genital Tract Pathological Changes by Vaccine-Promoted Neutralizing Antibodies Directed to the VD4 of the Major Outer Membrane Protein.
Olsen AW, Follmann F, Erneholm K, Rosenkrands I, Andersen P.
J Infect Dis. 2015 Mar 6. pii: jiv137. [Epub ahead of print]

The effect of hyperglycaemia on in vitro cytokine production and macrophage infection with Mycobacterium tuberculosis.
Lachmandas E, Vrieling F, Wilson LG, Joosten SA, Netea MG, Ottenhoff TH, van Crevel R.
PLoS One. 2015 Feb 9;10(2):e0117941. doi: 10.1371/journal.pone.0117941. eCollection 2015.

Acquired immunodeficiencies and tuberculosis: focus on HIV/AIDS and diabetes mellitus.
Ronacher K, Joosten SA, van Crevel R, Dockrell HM, Walzl G, Ottenhoff TH.
Immunol Rev. 2015 Mar;264(1):121-37. doi: 10.1111/imr.12257.

Co-delivery of PLGA encapsulated invariant NKT cell agonist with antigenic protein induce strong T cell-mediated antitumor immune responses.
Dölen Y, Kreutz M, Gileadi U, Tel J, Vasaturo A, van Dinther EA, van Hout-Kuijer MA, Cerundolo V, Figdor CG.
Oncoimmunology. 2015 Aug 12;5(1):e1068493.

Low Virulence and Lack of Airborne Transmission of the Dutch Highly Pathogenic Avian Influenza Virus H5N8 in Ferrets.
Richard M, Herfst S, van den Brand JM, Lexmond P, Bestebroer TM, Rimmelzwaan GF, Koopmans M, Kuiken T, Fouchier RA.
PLoS ONE. (2015) June 19; 10(6): e0129827. doi:10.1371/journal.pone.0129827.

The human immune response to tuberculosis and its treatment: a view from the blood.
Cliff JM, Kaufmann SH, McShane H, van Helden P, O'Garra A.
Immunol Rev. 2015 Mar;264(1):88-102. doi: 10.1111/imr.12269.

Biomarkers Can Identify Pulmonary Tuberculosis in HIV-infected Drug Users Months Prior to Clinical Diagnosis
Rosa Sloot, Maarten F. Schim van der Loeff, Erik W. van Zwet, Mariëlle C. Haks, Sytze T. Keizer, Maarten Scholing, Tom H.M. Ottenhoff, Martien W. Borgdorff, Simone A. Joosten,
EBioMedicine, Volume 2, Issue 2, February 2015, Pages 107-108

 

Publications in 2014

Rapid development of broadly influenza neutralizing antibodies through redundant mutations.
Pappas L, Foglierini M, Piccoli L, Kallewaard NL, Turrini F, Silacci C, Fernandez-Rodriguez B, Agatic G, Giacchetto-Sasselli I, Pellicciotta G, Sallusto F, Zhu Q, Vicenzi E, Corti D, Lanzavecchia A.
Nature. 2014 Dec 18;516(7531):418-22. doi: 10.1038/nature13764. Epub 2014 Oct 5.

The long pentraxin PTX3 as a key component of humoral innate immunity and a candidate diagnostic for inflammatory diseases.
Jaillon S, Bonavita E, Gentile S, Rubino M, Laface I, Garlanda C, Mantovani A.
Int Arch Allergy Immunol. 2014;165(3):165-78. doi: 10.1159/000368778. Epub 2014 Dec 20.

Clinical Immunology and Multiplex Biomarkers of Human Tuberculosis.
Walzl G, Haks MC, Joosten SA, Kleynhans L, Ronacher K, Ottenhoff TH.
Cold Spring Harb Perspect Med. 2014 Dec 4;5(4). pii: a018515. doi: 10.1101/cshperspect.a018515.


The Recombinant BCG ΔureC::hly Vaccine Targets the AIM2 Inflammasome to Induce Autophagy and Inflammation.
Saiga H, Nieuwenhuizen N, Gengenbacher M, Koehler A, Schuerer S, Moura-Alves P, Wagner I, Mollenkopf H, Dorhoi A, Kaufmann SH.
J Infect Dis. 2014 Dec 11. pii: jiu675. [Epub ahead of print]

Using Plasmids as DNA Vaccines for Infectious Diseases
John S. Tregoning, Ekaterina Kinnear
Microbiolspec November 2014 vol. 2 no. 6 doi:10.1128/microbiolspec.PLAS-0028-2014

Lung-residing myeloid-derived suppressors display dual functionality in murine pulmonary tuberculosis.
Knaul JK, Jörg S, Oberbeck-Mueller D, Heinemann E, Scheuermann L, Brinkmann V, Mollenkopf HJ, Yeremeev V, Kaufmann SH, Dorhoi A.
Am J Respir Crit Care Med. 2014 Nov 1;190(9):1053-66. doi: 10.1164/rccm.201405-0828OC.

Novel vaccination strategies against tuberculosis.
Andersen, P., S. H.E. Kaufmann
Cold Spring Harb Perspect Med4(6): a018523. (2014), doi: 10.1101/cshperspect.a018523.

CD8+ regulatory T cells, and not CD4+ T cells, dominate suppressive phenotype and function after in vitro live Mycobacterium bovis-BCG activation of human cells.
Boer MC, van Meijgaarden KE, Joosten SA, Ottenhoff TH.
PLoS One. 2014 Apr 8;9(4):e94192. doi: 10.1371/journal.pone.0094192. eCollection 2014.

Differences in antibody responses between trivalent inactivated influenza vaccine and live attenuated influenza vaccine correlate with the kinetics and magnitude of interferon signaling in children.
Cao RG, Suarez NM, Obermoser G, Lopez SM, Flano E, Mertz SE, Albrecht RA, García-Sastre, Mejias A, Xu H, Qin H, Blankenship D, Palucka K, Pascual V, Ramilo O.
J Infect Dis. 2014 Jul 15;210(2):224-33. doi: 10.1093/infdis/jiu079. Epub 2014 Feb 4.

Loading dendritic cells with PLA-p24 nanoparticles or MVA expressing HIV genes induces HIV-1-specific T cell responses.
Climent N, Munier S, Piqué N, García F, Pavot V, Primard C, Casanova V, Gatell JM, Verrier B, Gallart T.
Vaccine. 2014 Oct 29;32(47):6266-76. doi: 10.1016/j.vaccine.2014.09.010. Epub 2014 Sep 19.

Immunogenicity and reactogenicity of vaginal immunization with HIVgp140 in women, eliciting ex vivo inhibition of HIV-1, based on innate and T cell immunity.
Lewis DJM, Wang Y, Huo Z, Giemza R, Babaahmady K, Rahman D, Shattock RJ, Singh M and Lehner T. 2013.
J.Virol (2014)  July 9; doi:10.1128/JVI.01621-14

Murine granulocyte 1 macrophage colony stimulating factor expressed from a bicistronic SIV-based Integrase defective lentiviral vector does not enhance T-cell responses in mice.
Michelini Z, Negri D, Biava M, Baroncelli S, Spada M, Leone P, Bona R, Blasi M, Nègre D, Klotman ME, Cara A.
Viral Immunology (2014) December; 27(10):512-520, 2014. doi: 10.1089/vim.2014.0062.

The in vivo expressed Mycobacterium tuberculosis (IVE-TB) antigen Rv2034 induces CD4⁺ T-cells that protect against pulmonary infection in HLA-DR transgenic mice and guinea pigs.
Commandeur S, van den Eeden SJ, Dijkman K, Clark SO, van Meijgaarden KE, Wilson L, Franken KL, Williams A, Christensen D, Ottenhoff TH, Geluk A.
Vaccine. 2014 Jun 17;32(29):3580-8. doi: 10.1016/j.vaccine.2014.05.005. Epub 2014 May 14.

Clonal analysis of the T-cell response to in vivo expressed Mycobacterium tuberculosis protein Rv2034, using a CD154 expression based T-cell cloning method.
Commandeur S, Coppola M, Dijkman K, Friggen AH, van Meijgaarden KE, van den Eeden SJ, Wilson L, van der Ploeg-van Schip JJ, Franken KL, Geluk A, Ottenhoff TH.
PLoS One. 2014 Jun 6;9(6):e99203. doi: 10.1371/journal.pone.0099203. eCollection 2014.

Genetic PTX3 deficiency and aspergillosis in stem-cell transplantation.
Cunha, C. et al.
New Engl J Med. 370, 421-432, doi:10.1056/NEJMoa1211161 2014

The yin-yang of long pentraxin PTX3 in inflammation and immunity.
Daigo K, Mantovani A, Bottazzi B.
Immunol Lett. 2014 Sep;161(1):38-43. doi: 10.1016/j.imlet.2014.04.012. Epub 2014 May 1.

From empiricism to rational design: a personal perspective of the evolution of vaccine development.
De Gregorio E, Rappuoli R.
Nat Rev Immunol. 2014 Jul;14(7):505-14. doi: 10.1038/nri3694. Epub 2014 Jun 13.

Macrophage arginase-1 controls bacterial growth and pathology in hypoxic tuberculosis granulomas.
Duque-Correa MA, Kühl AA, Rodriguez PC, Zedler U, Schommer-Leitner S, Rao M, Weiner J 3rd, Hurwitz R, Qualls JE, Kosmiadi GA, Murray PJ, Kaufmann SH, Reece ST.
Proc Natl Acad Sci U S A. 2014 Sep 23;111(38):E4024-32. doi: 10.1073/pnas.1408839111. Epub 2014 Sep 8.

Designing vaccines for the twenty-first century society.
Finco O, Rappuoli R.
Front Immunol. 2014 Jan 23;5:12. doi: 10.3389/fimmu.2014.00012. eCollection 2014.

An autotransporter display platform for the development of multivalent recombinant bacterial vector vaccines.
Jong WS, Daleke-Schermerhorn MH, Vikström D, Ten Hagen-Jongman CM, de Punder K, van der Wel NN, van de Sandt CE, Rimmelzwaan GF, Follmann F, Agger EM, Andersen P, de Gier JW, Luirink J.
Microb Cell Fact. 2014 Nov 25;13:162. doi: 10.1186/s12934-014-0162-8.

A stable nanoparticulate DDA/MMG formulation acts synergistically with CpG ODN 1826 to enhance the CD4⁺ T-cell response.
Karlsen K, Korsholm KS, Mortensen R, Ghiasi SM, Andersen P, Foged C, Christensen D.
Nanomedicine (Lond). 2014 Dec;9(17):2625-38. doi: 10.2217/nnm.14.197.

Toward a unified biosignature for tuberculosis.
Maertzdorf J, Kaufmann SH, Weiner J 3rd.
Cold Spring Harb Perspect Med. 2014 Oct 23;5(1):a018531. doi: 10.1101/cshperspect.a018531.

Expression of active murine granulocyte-macrophage colony-stimulating factor in an Escherichia coli cell-free system.
Yang J, Kanter G, Voloshin A, Levy R, Swartz JR.
Biotechnol Prog. 2004 Nov-Dec;20(6):1689-96.

Combination of gene expression patterns in whole blood discriminate between tuberculosis infection states.
Mihret, A., et al 
BMC Infect. Dis. 14:257. doi: 10.1186/1471-2334-14-257 (2014)

Characterization of protective immune responses promoted by human antigen targets in a urogenital Chlamydia trachomatis mouse model.

Olsen AW, Andersen P, Follmann F.
Vaccine. 2014 Feb 3;32(6):685-92. doi: 10.1016/j.vaccine.2013.11.100. Epub 2013 Dec 21.

Recent progress in HIV vaccines inducing mucosal immune responses.
Pavot V, Rochereau N, Lawrence P, Girard MP, Genin C, Verrier B, Paul S.
AIDS. 2014 Jul 31;28(12):1701-18. doi: 10.1097/QAD.0000000000000308.

The aging bone marrow and its impact on immune responses in old age.
Pritz T, Weinberger B, Grubeck-Loebenstein B.
Immunol Lett. 2014 Nov;162(1 Pt B):310-5. doi: 10.1016/j.imlet.2014.06.016. Epub 2014 Jul 8.

A Enhanced inflammatory potential of CD4+ T cells that lack proteasome immunosubunit expression in a T-cell transfer-based colitis model.
Rasid O, Meulenbroeks, C, Gröne A, Zaiss D, Sijts,
PlosOne 2014 9(4):e95378 doi: 10.1371/journal.pone.0095378.


The DNA damage-regulated autophagy modulator DRAM1 links mycobacterial recognition via TLR-MYD88 to authophagic defense.

van der Vaart M, Korbee CJ, Lamers GE, Tengeler AC, Hosseini R, Haks MC, Ottenhoff TH, Spaink HP, Meijer AH.
Cell Host Microbe. 2014 Jun 11;15(6):753-67. doi: 10.1016/j.chom.2014.05.005.

Type V secretion: from biogenesis to biotechnology.
van Ulsen P, Rahman Su, Jong WS, Daleke-Schermerhorn MH, Luirink J.
Biochim Biophys Acta. 2014 Aug;1843(8):1592-611. doi: 10.1016/j.bbamcr.2013.11.006. Epub 2013 Nov 22.

Tuberculosis vaccines - rethinking the current paradigm.
Woodworth J, Andersen P.
Trends Immunology 35 (8): 387-95, 2014

Multiplexed label-free optical biosensor for medical diagnostics.
Bottazzi, B. et al.
Journal of biomedical optics 19, 17006, doi:10.1117/1.JBO.19.1.017006 (2014).

A new surface plasmon resonance-based immunoassay for rapid, reproducible and sensitive quantification of pentraxin-3 in human plasma.
Canovi, M. et al.,
Sensors (Basel). 14, 10864-75,  doi: 10.3390/s140610864. 2014.

Big science for vaccine development.
Rappuoli R, Medaglini D.
Vaccine. 2014 Aug 20;32(37):4705-7. doi: 10.1016/j.vaccine.2014.06.071. Epub 2014 Jun 25.

Decoration of outer membrane vesicles with multiple antigens by using an autotransporter approach.
Daleke-Schermerhorn MH, Felix T, Soprova Z, Ten Hagen-Jongman CM, Vikström D, Majlessi L, Beskers J, Follmann F, de Punder K, van der Wel NN, Baumgarten T, Pham TV, Piersma SR, Jiménez CR, van Ulsen P, de Gier JW, Leclerc C, Jong WS, Luirink J.
Appl Environ Microbiol. 2014 Sep 15;80(18):5854-65. doi: 10.1128/AEM.01941-14. Epub 2014 Jul 18.

Macrophage- and Neutrophil-Derived TNF-α Instructs Skin Langerhans Cells To Prime Antiviral Immune Responses.
Epaulard O, Adam L, Poux C, Zurawski G, Salabert N, Rosenbaum P, Dereuddre-Bosquet N, Zurawski S, Flamar AL, Oh S, Romain G, Chapon C, Banchereau J, Lévy Y, Le Grand R, Martinon F.
J Immunol. 2014 Sep 1;193(5):2416-26. doi: 10.4049/jimmunol.1303339. Epub 2014 Jul 23.

Vaccines, new opportunities for a new society.
Rappuoli R, Pizza M, Del Giudice G, De Gregorio E.

Proc Natl Acad Sci U S A. 2014 Aug 26;111(34):12288-93. doi: 10.1073/pnas.1402981111. Epub 2014 Aug 18.

Conventional but not plasmacytoid dendritic cells foster the systemic virus-induced type I IFN response needed for efficient CD8 T cell priming.
Hervas-Stubbs S, Riezu-Boj JI, Mancheño U, Rueda P, Lopez L, Alignani D, Rodríguez-García E, Thieblemont N, Leclerc C.
J Immunol. 2014 Aug 1;193(3):1151-61. doi: 10.4049/jimmunol.1301440. Epub 2014 Jun 27.

Antigen targeting to CD11b+ dendritic cells in association with TLR4/TRIF signaling promotes strong CD8+ T cell responses.
Dadaglio G, Fayolle C, Zhang X, Ryffel B, Oberkampf M, Felix T, Hervas-Stubbs S, Osicka R, Sebo P, Ladant D, Leclerc C.
J Immunol. 2014 Aug 15;193(4):1787-98. doi: 10.4049/jimmunol.1302974. Epub 2014 Jul 14.

Optimization of mucosal responses after intramuscular immunization with integrase defective lentiviral vector.
Rossi A, Michelini Z, Leone P, Borghi M, Blasi M, Bona R, Spada M, Grasso F, Gugliotta A, Klotman ME, Cara A, Negri D.
PLoS One. 2014 Sep 11;9(9):e107377. doi: 10.1371/journal.pone.0107377. eCollection 2014.

TRANSVAC workshop on standardisation and harmonisation of analytical platforms for HIV, TB and malaria vaccines: ‘How can big data help?’
Céline Dutruel, Jelle Thole, Mark Geels, Hans-Joachim Mollenkopf, Tom Ottenhoff, Carlos A. Guzman, Helen A. Fletcher, Odile Leroy, Stefan H.E. Kaufmann
DOI: 10.1016/j.vaccine.2014.06.014

Central Memory CD4+ T Cells Are Responsible for the Recombinant Bacillus Calmette-Guérin ΔureC::hly Vaccine's Superior Protection Against Tuberculosis.
Vogelzang A, Perdomo C, Zedler U, Kuhlmann S, Hurwitz R, Gengenbacher M, Kaufmann SH.
J Infect Dis. 2014 Jun 18. pii: jiu347. [Epub ahead of print]

The humoral pattern recognition molecule PTX3 is a key component of innate immunity against urinary tract infection.
Jaillon S, Moalli F, Ragnarsdottir B, Bonavita E, Puthia M, Riva F, Barbati E, Nebuloni M, Cvetko Krajinovic L, Markotic A, Valentino S, Doni A, Tartari S, Graziani G, Montanelli A, Delneste Y, Svanborg C, Garlanda C, Mantovani A.
Immunity. 2014 Apr 17;40(4):621-32. doi: 10.1016/j.immuni.2014.02.015.

The effect of vaginal immunization in women with HIVgp140 and HSP70 on HIV-1 replication, innate and T cell adaptive immunity
David J. M. Lewis, Yufei Wang, Zhiming Huo, Raphaela Giemza, Kaboutar Babaahmady, Durdana Rahman, Robin J. Shattock, Mahavir Singh and Thomas Lehner
Published ahead of print 9 July 2014, doi: 10.1128/JVI.01621-14 JVI.01621-14

Innovative strategies to identify M. tuberculosis antigens
and epitopes using genome-wide analyses

Annemieke Geluk, Krista E. van Meijgaarden, Simone A. Joosten, Susanna Commandeur and Tom H. Ottenhoff
Front. Immunol. | doi: 10.3389/fimmu.2014.00256

CD4 T cells with effector memory phenotype and function develop in the sterile environment of the fetus.
Zhang X, Mozeleski B, Lemoine S, Dériaud E, Lim A, Zhivaki D, Azria E, Le Ray C, Roguet G, Launay O, Vanet A, Leclerc C, Lo-Man R.
Sci Transl Med. 2014 May 28;6(238):238ra72. doi: 10.1126/scitranslmed.3008748.

Induction of CD8+ T-cell responses against subunit antigens by the novel cationic liposomal CAF09 adjuvant.
Korsholm KS, Hansen J, Karlsen K, Filskov J, Mikkelsen M, Lindenstrøm T, Schmidt ST, Andersen P, Christensen D.
Vaccine. 2014 May 28. pii: S0264-410X(14)00726-9. doi: 10.1016/j.vaccine.2014.05.050. [Epub ahead of print]

Plasmacytoid Dendritic Cells Engagement by Influenza Vaccine as a Surrogate Strategy for Driving T-Helper Type 1 Responses in Human Neonatal Settings.
Zhang X, Casartelli N, Lemoine S, Mozeleski B, Azria E, Le Ray C, Schwartz O, Launay O, Leclerc C, Lo-Man R.
J Infect Dis. 2014 Mar 21. [Epub ahead of print]

Progress in tuberculosis vaccine development and host-directed therapies-a state of the art review.
Kaufmann SH, Lange C, Rao M, Balaji KN, Lotze M, Schito M, Zumla AI, Maeurer M.
Lancet Respir Med. 2014 Apr;2(4):301-320. doi: 10.1016/S2213-2600(14)70033-5. Epub 2014 Mar 24.

The BCG replacement vaccine VPM1002: from drawing board to clinical trial.
Kaufmann SH, Cotton MF, Eisele B, Gengenbacher M, Grode L, Hesseling AC, Walzl G.
Expert Rev Vaccines. 2014 May;13(5):619-30. doi: 10.1586/14760584.2014.905746. Epub 2014 Apr 7.

Tuberculosis vaccine development at a divide.
Kaufmann SH.
Curr Opin Pulm Med. 2014 May;20(3):294-300. doi: 10.1097/MCP.0000000000000041.

Recent advances towards tuberculosis control: vaccines and biomarkers (Review).
Weiner 3rd J, Kaufmann SHE Max Planck Institute for Infection Biology, Berlin, Germany.
J Intern Med 2014; 275: 467–480.

Challenges and responses in human vaccine development.
Kaufmann SH, Juliana McElrath M, Lewis DJ, Del Giudice G.
Curr Opin Immunol. 2014 Feb 18;28C:18-26. doi: 10.1016/j.coi.2014.01.009. [Epub ahead of print]

Fusion of HCV Nonstructural Antigen to MHC Class II-associated Invariant Chain Enhances T-cell Responses Induced by Vectored Vaccines in Nonhuman Primates.
Capone S, Naddeo M, D'Alise AM, Abbate A, Grazioli F, Del Gaudio A, Del Sorbo M, Esposito ML, Ammendola V, Perretta G, Taglioni A, Colloca S, Nicosia A, Cortese R, Folgori A.
Mol Ther. 2014 Jan 30. doi: 10.1038/mt.2014.15. [Epub ahead of print]

Reverse translation in tuberculosis: neutrophils provide clues for understanding development of active disease
Anca Dorhoi, Marco Iannaccone, Jeroen Maertzdorf, Geraldine Nouailles, January Weiner 3rd and Stefan H. E. Kaufmann
Front. Immunol., 05 February 2014 | doi: 10.3389/fimmu.2014.00036

Tuberculosis vaccine with high predicted population coverage and compatibility with modern diagnostics.
Knudsen NP, Nørskov-Lauritsen S, Dolganov GM, Schoolnik GK, Lindenstrøm T, Andersen P, Agger EM, Aagaard C.
Proc Natl Acad Sci U S A. 2014 Jan 6. [Epub ahead of print]

 

Publications in 2013

A single amino acid substitution in the hemagglutinin of H3N2 subtype influenza A viruses is associated with resistance to the long pentraxin PTX3 and enhanced virulence in mice.
Job ER, Bottazzi B, Short KR, Deng YM, Mantovani A, Brooks AG, Reading PC.
J Immunol. 2014 Jan 1;192(1):271-81. doi: 10.4049/jimmunol.1301814. Epub 2013 Dec 4.

The interleukin-1 family: back to the future.
Garlanda C, Dinarello CA, Mantovani A.
Immunity. 2013 Dec 12;39(6):1003-18. doi: 10.1016/j.immuni.2013.11.010.

The adjuvant MF59 induces ATP release from muscle that potentiates response to vaccination.
Vono M, Taccone M, Caccin P, Gallotta M, Donvito G, Falzoni S, Palmieri E, Pallaoro M, Rappuoli R, Di Virgilio F, De Gregorio E, Montecucco C, Seubert A.
Proc Natl Acad Sci U S A. 2013 Dec 24;110(52):21095-100. doi: 10.1073/pnas.1319784110. Epub 2013 Dec 9.

CXCL5-secreting pulmonary epithelial cells drive destructive neutrophilic inflammation in tuberculosis
Geraldine Nouailles, Anca Dorhoi, Markus Koch, Jens Zerrahn, January Weiner, 3rd, Kellen C. Faé, Frida Arrey, Stefanie Kuhlmann, Silke Bandermann, Delia Loewe, Hans-Joachim Mollenkopf, Alexis Vogelzang, Catherine Meyer-Schwesinger, Hans-Willi Mittrücker, Gayle McEwen and Stefan H.E. Kaufmann
J Clin Invest. doi:10.1172/JCI72030.

CD4+ T Cell Priming as Biomarker to Study Immune Response to Preventive Vaccines
Annalisa Ciabattini, Elena Pettini, and Donata Medaglini
Front Immunol. 2013; 4: 421, Published online 2013 December 4. doi:  10.3389/fimmu.2013.00421, PMCID: PMC3850413


Tumor-Associated Macrophages as a Paradigm of Macrophage Plasticity, Diversity, and Polarization: Lessons and Open Questions.
Mantovani A and M Locati.
Arterioscler Thromb Vasc Biol (2013) July;33:1478-1483  doi:10.1161/ATVBAHA.113.300168.

Recall Responses to Tetanus and Diphtheria Vaccination Are Frequently Insufficient in Elderly Persons
Birgit Weinberger, Michael Schirmer, Raffaella Matteucci Gothe, Uwe Siebert, Dietmar Fuchs, and Beatrix Grubeck-Loebenstein
PLoS One. 2013; 8(12): e82967. Published online 2013 December 11. doi:  10.1371/journal.pone.0082967

Vaginal Immunization to Elicit Primary T-Cell Activation and Dissemination
Elena Pettini, Gennaro Prota, Annalisa Ciabattini, Alessandro Boianelli, Fabio Fiorino, Gianni Pozzi, Antonio Vicino, Donata Medaglini
December 05, 2013, DOI: 10.1371/journal.pone.0080545

Low Induction of Proinflammatory Cytokines Parallels Evolutionary Success of Modern Strains within the Mycobacterium tuberculosis Beijing Genotype.
van Laarhoven A, Mandemakers JJ, Kleinnijenhuis J, Enaimi M, Lachmandas E, Joosten LA, Ottenhoff TH, Netea MG, van Soolingen D, van Crevel R.
Infect Immun. 2013 Oct;81(10):3750-6. doi: 10.1128/IAI.00282-13. Epub 2013 Jul 29.

Ex vivo analysis of human memory B lymphocytes specific for a and B influenza hemagglutinin by polychromatic flow-cytometry.
Bardelli M, Alleri L, Angiolini F, Buricchi F, Tavarini S, Sammicheli C, Nuti S, Degl'innocenti E, Isnardi I, Fragapane E, Del Giudice G, Castellino F, Galli G.
PLoS One. 2013 Aug 15;8(8):e70620. doi: 10.1371/journal.pone.0070620.

Human circulating influenza-CD4+ ICOS1+IL-21+ T cells expand after vaccination, exert helper function, and predict antibody responses.
Spensieri F, Borgogni E, Zedda L, Bardelli M, Buricchi F, Volpini G, Fragapane E, Tavarini S, Finco O, Rappuoli R, Del Giudice G, Galli G, Castellino F.
Proc Natl Acad Sci U S A. 2013 Aug 27;110(35):14330-5. doi: 10.1073/pnas.1311998110. Epub 2013 Aug 12.

MicroRNA-223 controls susceptibility to tuberculosis by regulating lung neutrophil recruitment.
Dorhoi A, Iannaccone M, Farinacci M, Faé KC, Schreiber J, Moura-Alves P, Nouailles G, Mollenkopf HJ, Oberbeck-Müller D, Jörg S, Heinemann E, Hahnke K, Löwe D, Del Nonno F, Goletti D, Capparelli R, Kaufmann SH.
J Clin Invest. 2013 Oct 1. pii: 67604. doi: 10.1172/JCI67604. [Epub ahead of print]

A Helicopter Perspective on TB Biomarkers: Pathway and Process Based Analysis of Gene Expression Data Provides New Insight into TB Pathogenesis
Simone A. Joosten, Helen A. Fletcher, Tom H. M. Ottenhoff
PLoS ONE 8(9): e73230. doi:10.1371/journal.pone.0073230

Immunologic correlates of protection and potential role for adjuvants to improve influenza vaccines in older adults
McElhaney JE, Coler RN, Baldwin SL.
Expert Rev Vaccines. 2013 Jul;12(7):759-66. doi: 10.1586/14760584.2013.811193.

Encapsulation of Nod1 and Nod2 receptor ligands into poly(lactic acid) nanoparticles potentiates their immune properties.
Pavot V, Rochereau N, Primard C, Genin C, Perouzel E, Lioux T, Paul S, Verrier B.
J Control Release. 2013 Apr 10;167(1):60-7. doi: 10.1016/j.jconrel.2013.01.015. Epub 2013 Jan 23.

The "sweet" side of a long pentraxin: how glycosylation affects PTX3 functions in innate immunity and inflammation.
Inforzato A, Reading PC, Barbati E, Bottazzi B, Garlanda C, Mantovani A.
Front Immunol. 2012;3:407. doi: 10.3389/fimmu.2012.00407. Epub 2013 Jan 7.

PTX3 as a paradigm for the interaction of pentraxins with the Complement system.
Inforzato A, Doni A, Barajon I, Leone R, Garlanda C, Bottazzi B, Mantovani A.
Semin Immunol. 2013 Jun 6. pii: S1044-5323(13)00031-6. doi: 10.1016/j.smim.2013.05.002. [Epub ahead of print]

The adjuvant effect of MF59 is due to the oil-in-water emulsion formulation, none of the individual components induce a comparable adjuvant effect.
Calabro S, Tritto E, Pezzotti A, Taccone M, Muzzi A, Bertholet S, De Gregorio E, O'Hagan DT, Baudner B, Seubert A.
Vaccine. 2013 May 16. pii: S0264-410X(13)00563-X. doi: 10.1016/j.vaccine.2013.05.007. [Epub ahead of print]

Tuberculosis vaccines: Time to think about the next generation
Stefan H.E. Kaufmann
Seminars in immunology, 21 May 2013

Serum Amyloid P Is a Sialylated Glycoprotein Inhibitor of Influenza A Viruses.
Job ER, Bottazzi B, Gilbertson B, Edenborough KM, Brown LE, et al. (2013)
PLoS ONE 8(3): e59623. doi:10.1371/journal.pone.0059623

Enzyme-linked immunospot assays for direct ex vivo measurement of vaccine-induced human humoral immune responses in blood
Giulietta Saletti, Nicolas Çuburu, Jae Seung Yang, Ayan Dey & Cecil Czerkinsky
Nature Protocols 8, 1073–1087 (2013) doi:10.1038/nprot.2013.058

Prime-boost strategies in mucosal immunization affect local IgA production and the type of Th response.
Fiorino F, Pettini E, Pozzi G, Medaglini D and Ciabattini A (2013).
Front. Immunol. 4:128. doi: 10.3389/fimmu.2013.00128

The gracefully aging immune system.
Boraschi D., Aguado T.M., Dutel C., Goronzy J., Louis J., Grubeck-Loebenstein B., Rappuoli R., Del Giudice G.
Sci Transl Med 2013;185:185ps8

The influence of influenza virus infections on the development of tuberculosis.
de Paus RA, van Crevel R, van Beek R, Sahiratmadja E, Alisjahbana B, Marzuki S, Rimmelzwaan GF, van Dissel JT, Ottenhoff TH, van de Vosse E.
Tuberculosis (Edinb). 2013 May;93(3):338-42. doi: 10.1016/j.tube.2013.02.006. Epub 2013 Mar 7.

Tumor associated macrophages and neutrophils in cancer.
Galdiero MR, Bonavita E, Barajon I, Garlanda C, Mantovani A, Jaillon S.
Immunobiology. 2013 Nov;218(11):1402-10. doi: 10.1016/j.imbio.2013.06.003. Epub 2013 Jun 17.

OMIP-016: Characterization of antigen-responsive macaque and human T-cells.
Guenounou S, Bosquet N, Dembek CJ, Le Grand R, Cosma A.
Cytometry A. 2013 Feb;83(2):182-4. doi: 10.1002/cyto.a.22233. Epub 2012 Nov 26.

Neutrophils in innate and adaptive immunity.
Jaillon S, Galdiero MR, Del Prete D, Cassatella MA, Garlanda C, Mantovani A.
Semin Immunopathol. 2013 Jul;35(4):377-94. doi: 10.1007/s00281-013-0374-8. Epub 2013 Apr 4.

Prototypic long pentraxin PTX3 is present in breast milk, spreads in tissues, and protects neonate mice from Pseudomonas aeruginosa lung infection.
Jaillon S, Mancuso G, Hamon Y, Beauvillain C, Cotici V, Midiri A, Bottazzi B, Nebuloni M, Garlanda C, Frémaux I, Gauchat JF, Descamps P, Beninati C, Mantovani A, Jeannin P, Delneste Y.
J Immunol. 2013 Aug 15;191(4):1873-82. doi: 10.4049/jimmunol.1201642. Epub 2013 Jul 17.

Inflammation in tuberculosis: interactions, imbalances and interventions.
Kaufmann, S.H.E., A. Dorhoi
(Special issue: Host pathogens) Curr. Opin. Immunol. 25:441–449 2013

The potential mechanism of HSP70-derived stimulating peptide epitope in autoimmune Vitiligo.
Lehner T and Wang Y. 2013.
Sci. Trans. Med. (letter) 5:174.


The role of stress-induced activation of HSP70 in dendritic cells, CD4+ T cell, memory and adjuvanticity.
Lehner T and Wang Y.  2013.
Chapter in book entitled Moonlighting Cell Stress Proteins in Microbial Infections, Heat Shock Proteins. Ed. B Henderson. Springer Science.

The long pentraxin PTX3: a paradigm for humoral pattern recognition molecules.
Mantovani A, Valentino S, Gentile S, Inforzato A, Bottazzi B, Garlanda C.
Ann N Y Acad Sci. 2013 May;1285:1-14. doi: 10.1111/nyas.12043. Epub 2013 Mar 25.

Control of Chronic Mycobacterium tuberculosis Infection by CD4 KLRG1- IL-2-Secreting Central Memory Cells.
Lindenstrøm T, Knudsen NP, Agger EM, Andersen P.
J Immunol. 2013 May 15.

HMGB1 and leukocyte migration during trauma and sterile inflammation.
Venereau E, Schiraldi M, Uguccioni M, Bianchi ME.
Mol Immunol. 2013 Aug;55(1):76-82. doi: 10.1016/j.molimm.2012.10.037. Epub 2012 Dec 1.

 

 

Publications in 2012

Interactions of the humoral pattern recognition molecule PTX3 with the complement system.
Doni A, Garlanda C, Bottazzi B, Meri S, Garred P, Mantovani A.
Immunobiology. 2012 Nov;217(11):1122-8. doi: 10.1016/j.imbio.2012.07.004.

The dual role of biomarkers for understanding basic principles and devising novel intervention strategies in tuberculosis.
Weiner J, Maertzdorf J, Kaufmann SH.
Ann N Y Acad Sci. 2013 Apr;1283:22-9. doi: 10.1111/j.1749-6632.2012.06802.x. Epub 2012 Nov 26.

Structural vaccinology starts to deliver.
Dormitzer PR, Grandi G, Rappuoli R.
Nat Rev Microbiol. 2012 Dec;10(12):807-13. doi: 10.1038/nrmicro2893.

The recombinant tuberculosis vaccine rBCG ΔureC::hly+ induces apoptotic vescicles for improved priming of CD4+ and CD8+ T cells.
Farinacci, M., S. Weber, S.H.E. Kaufmann
Vaccine, 30: 7608-7614 2012

Tuberculosis vaccine development: strength lies in tenacity.
Kaufmann SH.
Trends Immunol. 2012 Jul;33(7):373-9. doi: 10.1016/j.it.2012.03.004. Epub 2012 May 3.

The knowns and unknowns of the immunopathogenesis of tuberculosis.
Ottenhoff TH.
Int J Tuberc Lung Dis. 2012 Nov;16(11):1424-32. doi: 10.5588/ijtld.12.0479.

State of the art in vaccine development against TB
Ottenhoff T H.M.and Kaufmann S.H.E
European Respiratory Society Monograph, Vol. 58. 2012. P.59-71 Published online November 29, 2012 doi:10.1183/1025448x.10015912

Comparison of temporal and spatial dynamics of seasonal H3N2, pandemic H1N1 and highly pathogenic avian influenza H5N1 virus infections in ferrets.
van den Brand JM, Stittelaar KJ, van Amerongen G, Reperant L, de Waal L, Osterhaus AD, Kuiken T.
PLoS One. 2012;7(8):e42343. doi: 10.1371/journal.pone.0042343. Epub 2012 Aug 8.

CD39 is involved in mediating suppression by Mycobacterium bovis BCG-activated human CD8+CD39+ regulatory T cells
Mardi C. Boer, Krista E. van Meijgaarden, Jérémy Bastid, Tom H.M. Ottenhoff, Simone A. Joosten
DOI: 10.1002/eji.201243286

Mutually exclusive redox forms of HMGB1 promote cell recruitment or proinflammatory cytokine release.
Venereau E, Casalgrandi M, Schiraldi M, Antoine DJ, Cattaneo A, De Marchis F, Liu J, Antonelli A, Preti A, Raeli L, Shams SS, Yang H, Varani L, Andersson U, Tracey KJ, Bachi A, Uguccioni M, Bianchi ME.
Source
J Exp Med. 2012 Aug 27;209(9):1519-28. doi: 10.1084/jem.20120189. Epub 2012 Aug 6.

Recombinant live vaccine candidates against tuberculosis.
Kaufmann SH, Gengenbacher M.
Curr Opin Biotechnol. 2012 Apr 4. [Epub ahead of print]

Common patterns and disease-related signatures in tuberculosis and sarcoidosis
Jeroen Maertzdorf, January Weiner, Hans-Joachim Mollenkopf,TBornotTB Network, Torsten Bauer, Antje Prasse, Joachim Müller-Quernheim, and Stefan H. E. Kaufmann
Published online before print April 30, 2012, doi: 10.1073/pnas.1121072109 PNAS April 30, 2012

Induction of protective immunity against Mycobacterium tuberculosis by delivery of ESX antigens into airway dendritic cells.
Dong H, Stanek O, Rudilla Salvador F, Länger U, Morillon E, Ung C, Sebo P, Leclerc C, Majlessi L.
Mucosal Immunol. 2012 Oct 3. doi: 10.1038/mi.2012.92.

New pathways of protective and pathological host defense to mycobacteria.
Ottenhoff TH.
Trends Microbiol. 2012 Sep;20(9):419-28. Epub 2012 Jul 10.

Genome-wide expression profiling identifies type 1 interferon response pathways in active tuberculosis.
Ottenhoff TH, Dass RH, Yang N, Zhang MM, Wong HE, Sahiratmadja E, Khor CC, Alisjahbana B, van Crevel R, Marzuki S, Seielstad M, van de Vosse E, Hibberd ML.
PLoS One. 2012;7(9):e45839. doi: 10.1371/journal.pone.0045839. Epub 2012 Sep 21.

Simian immunodeficiency virus-Vpx for improving integrase defective lentiviral vector-based vaccines.
Negri DR, Rossi A, Blasi M, Michelini Z, Leone P, Chiantore MV, Baroncelli S, Perretta G, Cimarelli A, Klotman ME, Cara A.
Retrovirology. 2012 Aug 22;9(1):69.

Polyethyleneimine is a potent mucosal adjuvant for viral glycoprotein antigens.
Frank Wegmann, Kate H Gartlan, Ali M Harandi, Sarah A Brinckmann, Margherita Coccia, William R Hillson, Wai Ling Kok, Suzanne Cole, Ling-Pei Ho, Teresa Lambe, Manoj Puthia, Catharina Svanborg, Erin M Scherer, George Krashias, Adam Williams, Joseph N Blattman, Philip D Greenberg, Richard A Flavell, Amin E Moghaddam, Neil C Sheppard, Quentin J Sattentau   
Nat Biotechnol. 2012 Aug 26;: 22922673

A comparative study of stress-mediated immunological functions with the adjuvanticity of alum.
Wang Y, Rahman D, Lehner T.
J Biol Chem. 2012 May 18;287(21):17152-60. Epub 2012 Apr 3.

Enabling biomarkers for tuberculosis control [State of the Art Series. New tools. Number 3 in the series]
Maertzdorf, J.; Weiner III, J.; Kaufmann, S. H. E.
The International Journal of Tuberculosis and Lung Disease, Volume 16, Number 9, 1 September 2012 , pp. 1140-1148(9)

HMGB1 promotes recruitment of inflammatory cells to damaged tissues by forming a complex with CXCL12 and signaling via CXCR4
Schiraldi M, Raucci A, Muñoz LM, Livoti E, Celona B, Venereau E, Apuzzo T, De Marchis F, Pedotti M, Bachi A, Thelen M, Varani L, Mellado M, Proudfoot A, Bianchi ME, Uguccioni M.
J Exp Med. 2012 Mar 12;209(3):551-63. Epub 2012 Feb 27.

A structurally informed autotransporter platform for efficient heterologous protein secretion and display
Wouter SP Jong, Zora Soprova, Karin de Punder, Corinne M ten Hagen-Jongman, Samuel Wagner, David Wickström, Jan-Willem de Gier, Peter Andersen, Nicole N van der Wel, Joen Luirink
Microbial Cell Factories 2012, 11:85 (18 June 2012)

ADITEC: Joining Forces for Next-Generation Vaccines
R. Rappuoli, D. Medaglini
Sci. Transl. Med. 4, 128cm4 (2012)

The Role of Innate APOBEC3G and Adaptive AID Immune Responses in HLA-HIV/SIV Immunized SHIV Infected Macaques.
Wang Y, Whittall T, Rahman D, Bunnik EM, Vaughan R, Schøller J, Bergmeier LA, Montefiori D, Singh M, Schuitemaker H and Lehner T. 
2012.  PlosOne. 7(4): e34433.

Contact

Prof. Donata Medaglini
Scientific coordinator
+39 0577 233307
medaglini@sclavo.org