Publications in 2014

Rapid development of broadly influenza neutralizing antibodies through redundant mutations.
Pappas L, Foglierini M, Piccoli L, Kallewaard NL, Turrini F, Silacci C, Fernandez-Rodriguez B, Agatic G, Giacchetto-Sasselli I, Pellicciotta G, Sallusto F, Zhu Q, Vicenzi E, Corti D, Lanzavecchia A.
Nature. 2014 Dec 18;516(7531):418-22. doi: 10.1038/nature13764. Epub 2014 Oct 5.

The long pentraxin PTX3 as a key component of humoral innate immunity and a candidate diagnostic for inflammatory diseases.
Jaillon S, Bonavita E, Gentile S, Rubino M, Laface I, Garlanda C, Mantovani A.
Int Arch Allergy Immunol. 2014;165(3):165-78. doi: 10.1159/000368778. Epub 2014 Dec 20.

Clinical Immunology and Multiplex Biomarkers of Human Tuberculosis.
Walzl G, Haks MC, Joosten SA, Kleynhans L, Ronacher K, Ottenhoff TH.
Cold Spring Harb Perspect Med. 2014 Dec 4;5(4). pii: a018515. doi: 10.1101/cshperspect.a018515.

The Recombinant BCG ΔureC::hly Vaccine Targets the AIM2 Inflammasome to Induce Autophagy and Inflammation.
Saiga H, Nieuwenhuizen N, Gengenbacher M, Koehler A, Schuerer S, Moura-Alves P, Wagner I, Mollenkopf H, Dorhoi A, Kaufmann SH.
J Infect Dis. 2014 Dec 11. pii: jiu675. [Epub ahead of print]

Using Plasmids as DNA Vaccines for Infectious Diseases
John S. Tregoning, Ekaterina Kinnear
Microbiolspec November 2014 vol. 2 no. 6 doi:10.1128/microbiolspec.PLAS-0028-2014

Lung-residing myeloid-derived suppressors display dual functionality in murine pulmonary tuberculosis.
Knaul JK, Jörg S, Oberbeck-Mueller D, Heinemann E, Scheuermann L, Brinkmann V, Mollenkopf HJ, Yeremeev V, Kaufmann SH, Dorhoi A.
Am J Respir Crit Care Med. 2014 Nov 1;190(9):1053-66. doi: 10.1164/rccm.201405-0828OC.

Novel vaccination strategies against tuberculosis.
Andersen, P., S. H.E. Kaufmann
Cold Spring Harb Perspect Med4(6): a018523. (2014), doi: 10.1101/cshperspect.a018523.

CD8+ regulatory T cells, and not CD4+ T cells, dominate suppressive phenotype and function after in vitro live Mycobacterium bovis-BCG activation of human cells.
Boer MC, van Meijgaarden KE, Joosten SA, Ottenhoff TH.
PLoS One. 2014 Apr 8;9(4):e94192. doi: 10.1371/journal.pone.0094192. eCollection 2014.

Differences in antibody responses between trivalent inactivated influenza vaccine and live attenuated influenza vaccine correlate with the kinetics and magnitude of interferon signaling in children.
Cao RG, Suarez NM, Obermoser G, Lopez SM, Flano E, Mertz SE, Albrecht RA, García-Sastre, Mejias A, Xu H, Qin H, Blankenship D, Palucka K, Pascual V, Ramilo O.
J Infect Dis. 2014 Jul 15;210(2):224-33. doi: 10.1093/infdis/jiu079. Epub 2014 Feb 4.

Loading dendritic cells with PLA-p24 nanoparticles or MVA expressing HIV genes induces HIV-1-specific T cell responses.
Climent N, Munier S, Piqué N, García F, Pavot V, Primard C, Casanova V, Gatell JM, Verrier B, Gallart T.
Vaccine. 2014 Oct 29;32(47):6266-76. doi: 10.1016/j.vaccine.2014.09.010. Epub 2014 Sep 19.

Immunogenicity and reactogenicity of vaginal immunization with HIVgp140 in women, eliciting ex vivo inhibition of HIV-1, based on innate and T cell immunity.
Lewis DJM, Wang Y, Huo Z, Giemza R, Babaahmady K, Rahman D, Shattock RJ, Singh M and Lehner T. 2013.
J.Virol (2014)  July 9; doi:10.1128/JVI.01621-14

Murine granulocyte 1 macrophage colony stimulating factor expressed from a bicistronic SIV-based Integrase defective lentiviral vector does not enhance T-cell responses in mice.
Michelini Z, Negri D, Biava M, Baroncelli S, Spada M, Leone P, Bona R, Blasi M, Nègre D, Klotman ME, Cara A.
Viral Immunology (2014) December; 27(10):512-520, 2014. doi: 10.1089/vim.2014.0062.

The in vivo expressed Mycobacterium tuberculosis (IVE-TB) antigen Rv2034 induces CD4⁺ T-cells that protect against pulmonary infection in HLA-DR transgenic mice and guinea pigs.
Commandeur S, van den Eeden SJ, Dijkman K, Clark SO, van Meijgaarden KE, Wilson L, Franken KL, Williams A, Christensen D, Ottenhoff TH, Geluk A.
Vaccine. 2014 Jun 17;32(29):3580-8. doi: 10.1016/j.vaccine.2014.05.005. Epub 2014 May 14.

Clonal analysis of the T-cell response to in vivo expressed Mycobacterium tuberculosis protein Rv2034, using a CD154 expression based T-cell cloning method.
Commandeur S, Coppola M, Dijkman K, Friggen AH, van Meijgaarden KE, van den Eeden SJ, Wilson L, van der Ploeg-van Schip JJ, Franken KL, Geluk A, Ottenhoff TH.
PLoS One. 2014 Jun 6;9(6):e99203. doi: 10.1371/journal.pone.0099203. eCollection 2014.

Genetic PTX3 deficiency and aspergillosis in stem-cell transplantation.
Cunha, C. et al.
New Engl J Med. 370, 421-432, doi:10.1056/NEJMoa1211161 2014

The yin-yang of long pentraxin PTX3 in inflammation and immunity.
Daigo K, Mantovani A, Bottazzi B.
Immunol Lett. 2014 Sep;161(1):38-43. doi: 10.1016/j.imlet.2014.04.012. Epub 2014 May 1.

From empiricism to rational design: a personal perspective of the evolution of vaccine development.
De Gregorio E, Rappuoli R.
Nat Rev Immunol. 2014 Jul;14(7):505-14. doi: 10.1038/nri3694. Epub 2014 Jun 13.

Macrophage arginase-1 controls bacterial growth and pathology in hypoxic tuberculosis granulomas.
Duque-Correa MA, Kühl AA, Rodriguez PC, Zedler U, Schommer-Leitner S, Rao M, Weiner J 3rd, Hurwitz R, Qualls JE, Kosmiadi GA, Murray PJ, Kaufmann SH, Reece ST.
Proc Natl Acad Sci U S A. 2014 Sep 23;111(38):E4024-32. doi: 10.1073/pnas.1408839111. Epub 2014 Sep 8.

Designing vaccines for the twenty-first century society.
Finco O, Rappuoli R.
Front Immunol. 2014 Jan 23;5:12. doi: 10.3389/fimmu.2014.00012. eCollection 2014.

An autotransporter display platform for the development of multivalent recombinant bacterial vector vaccines.
Jong WS, Daleke-Schermerhorn MH, Vikström D, Ten Hagen-Jongman CM, de Punder K, van der Wel NN, van de Sandt CE, Rimmelzwaan GF, Follmann F, Agger EM, Andersen P, de Gier JW, Luirink J.
Microb Cell Fact. 2014 Nov 25;13:162. doi: 10.1186/s12934-014-0162-8.

A stable nanoparticulate DDA/MMG formulation acts synergistically with CpG ODN 1826 to enhance the CD4⁺ T-cell response.
Karlsen K, Korsholm KS, Mortensen R, Ghiasi SM, Andersen P, Foged C, Christensen D.
Nanomedicine (Lond). 2014 Dec;9(17):2625-38. doi: 10.2217/nnm.14.197.

Toward a unified biosignature for tuberculosis.
Maertzdorf J, Kaufmann SH, Weiner J 3rd.
Cold Spring Harb Perspect Med. 2014 Oct 23;5(1):a018531. doi: 10.1101/cshperspect.a018531.

Expression of active murine granulocyte-macrophage colony-stimulating factor in an Escherichia coli cell-free system.
Yang J, Kanter G, Voloshin A, Levy R, Swartz JR.
Biotechnol Prog. 2004 Nov-Dec;20(6):1689-96.

Combination of gene expression patterns in whole blood discriminate between tuberculosis infection states.
Mihret, A., et al
BMC Infect. Dis. 14:257. doi: 10.1186/1471-2334-14-257 (2014)

Characterization of protective immune responses promoted by human antigen targets in a urogenital Chlamydia trachomatis mouse model.

Olsen AW, Andersen P, Follmann F.
Vaccine. 2014 Feb 3;32(6):685-92. doi: 10.1016/j.vaccine.2013.11.100. Epub 2013 Dec 21.

Recent progress in HIV vaccines inducing mucosal immune responses.
Pavot V, Rochereau N, Lawrence P, Girard MP, Genin C, Verrier B, Paul S.
AIDS. 2014 Jul 31;28(12):1701-18. doi: 10.1097/QAD.0000000000000308.

The aging bone marrow and its impact on immune responses in old age.
Pritz T, Weinberger B, Grubeck-Loebenstein B.
Immunol Lett. 2014 Nov;162(1 Pt B):310-5. doi: 10.1016/j.imlet.2014.06.016. Epub 2014 Jul 8.

A Enhanced inflammatory potential of CD4+ T cells that lack proteasome immunosubunit expression in a T-cell transfer-based colitis model.
Rasid O, Meulenbroeks, C, Gröne A, Zaiss D, Sijts,
PlosOne 2014 9(4):e95378 doi: 10.1371/journal.pone.0095378.


The DNA damage-regulated autophagy modulator DRAM1 links mycobacterial recognition via TLR-MYD88 to authophagic defense.

van der Vaart M, Korbee CJ, Lamers GE, Tengeler AC, Hosseini R, Haks MC, Ottenhoff TH, Spaink HP, Meijer AH.
Cell Host Microbe. 2014 Jun 11;15(6):753-67. doi: 10.1016/j.chom.2014.05.005.

Type V secretion: from biogenesis to biotechnology.
van Ulsen P, Rahman Su, Jong WS, Daleke-Schermerhorn MH, Luirink J.
Biochim Biophys Acta. 2014 Aug;1843(8):1592-611. doi: 10.1016/j.bbamcr.2013.11.006. Epub 2013 Nov 22.

Tuberculosis vaccines – rethinking the current paradigm.
Woodworth J, Andersen P.
Trends Immunology 35 (8): 387-95, 2014

Multiplexed label-free optical biosensor for medical diagnostics.
Bottazzi, B. et al.
Journal of biomedical optics 19, 17006, doi:10.1117/1.JBO.19.1.017006 (2014).

A new surface plasmon resonance-based immunoassay for rapid, reproducible and sensitive quantification of pentraxin-3 in human plasma.
Canovi, M. et al.,
Sensors (Basel). 14, 10864-75,  doi: 10.3390/s140610864. 2014.

Big science for vaccine development.
Rappuoli R, Medaglini D.
Vaccine. 2014 Aug 20;32(37):4705-7. doi: 10.1016/j.vaccine.2014.06.071. Epub 2014 Jun 25.

Decoration of outer membrane vesicles with multiple antigens by using an autotransporter approach.
Daleke-Schermerhorn MH, Felix T, Soprova Z, Ten Hagen-Jongman CM, Vikström D, Majlessi L, Beskers J, Follmann F, de Punder K, van der Wel NN, Baumgarten T, Pham TV, Piersma SR, Jiménez CR, van Ulsen P, de Gier JW, Leclerc C, Jong WS, Luirink J.
Appl Environ Microbiol. 2014 Sep 15;80(18):5854-65. doi: 10.1128/AEM.01941-14. Epub 2014 Jul 18.

Macrophage- and Neutrophil-Derived TNF-α Instructs Skin Langerhans Cells To Prime Antiviral Immune Responses.
Epaulard O, Adam L, Poux C, Zurawski G, Salabert N, Rosenbaum P, Dereuddre-Bosquet N, Zurawski S, Flamar AL, Oh S, Romain G, Chapon C, Banchereau J, Lévy Y, Le Grand R, Martinon F.
J Immunol. 2014 Sep 1;193(5):2416-26. doi: 10.4049/jimmunol.1303339. Epub 2014 Jul 23.

Vaccines, new opportunities for a new society.
Rappuoli R, Pizza M, Del Giudice G, De Gregorio E.

Proc Natl Acad Sci U S A. 2014 Aug 26;111(34):12288-93. doi: 10.1073/pnas.1402981111. Epub 2014 Aug 18.

Conventional but not plasmacytoid dendritic cells foster the systemic virus-induced type I IFN response needed for efficient CD8 T cell priming.
Hervas-Stubbs S, Riezu-Boj JI, Mancheño U, Rueda P, Lopez L, Alignani D, Rodríguez-García E, Thieblemont N, Leclerc C.
J Immunol. 2014 Aug 1;193(3):1151-61. doi: 10.4049/jimmunol.1301440. Epub 2014 Jun 27.

Antigen targeting to CD11b+ dendritic cells in association with TLR4/TRIF signaling promotes strong CD8+ T cell responses.
Dadaglio G, Fayolle C, Zhang X, Ryffel B, Oberkampf M, Felix T, Hervas-Stubbs S, Osicka R, Sebo P, Ladant D, Leclerc C.
J Immunol. 2014 Aug 15;193(4):1787-98. doi: 10.4049/jimmunol.1302974. Epub 2014 Jul 14.

Optimization of mucosal responses after intramuscular immunization with integrase defective lentiviral vector.
Rossi A, Michelini Z, Leone P, Borghi M, Blasi M, Bona R, Spada M, Grasso F, Gugliotta A, Klotman ME, Cara A, Negri D.
PLoS One. 2014 Sep 11;9(9):e107377. doi: 10.1371/journal.pone.0107377. eCollection 2014.

TRANSVAC workshop on standardisation and harmonisation of analytical platforms for HIV, TB and malaria vaccines: ‘How can big data help?’
Céline Dutruel, Jelle Thole, Mark Geels, Hans-Joachim Mollenkopf, Tom Ottenhoff, Carlos A. Guzman, Helen A. Fletcher, Odile Leroy, Stefan H.E. Kaufmann
DOI: 10.1016/j.vaccine.2014.06.014

Central Memory CD4+ T Cells Are Responsible for the Recombinant Bacillus Calmette-Guérin ΔureC::hly Vaccine’s Superior Protection Against Tuberculosis.
Vogelzang A, Perdomo C, Zedler U, Kuhlmann S, Hurwitz R, Gengenbacher M, Kaufmann SH.
J Infect Dis. 2014 Jun 18. pii: jiu347. [Epub ahead of print]

The humoral pattern recognition molecule PTX3 is a key component of innate immunity against urinary tract infection.
Jaillon S, Moalli F, Ragnarsdottir B, Bonavita E, Puthia M, Riva F, Barbati E, Nebuloni M, Cvetko Krajinovic L, Markotic A, Valentino S, Doni A, Tartari S, Graziani G, Montanelli A, Delneste Y, Svanborg C, Garlanda C, Mantovani A.
Immunity. 2014 Apr 17;40(4):621-32. doi: 10.1016/j.immuni.2014.02.015.

The effect of vaginal immunization in women with HIVgp140 and HSP70 on HIV-1 replication, innate and T cell adaptive immunity
David J. M. Lewis, Yufei Wang, Zhiming Huo, Raphaela Giemza, Kaboutar Babaahmady, Durdana Rahman, Robin J. Shattock, Mahavir Singh and Thomas Lehner
Published ahead of print 9 July 2014, doi: 10.1128/JVI.01621-14 JVI.01621-14

Innovative strategies to identify M. tuberculosis antigens
and epitopes using genome-wide analyses

Annemieke Geluk, Krista E. van Meijgaarden, Simone A. Joosten, Susanna Commandeur and Tom H. Ottenhoff
Front. Immunol. | doi: 10.3389/fimmu.2014.00256

CD4 T cells with effector memory phenotype and function develop in the sterile environment of the fetus.
Zhang X, Mozeleski B, Lemoine S, Dériaud E, Lim A, Zhivaki D, Azria E, Le Ray C, Roguet G, Launay O, Vanet A, Leclerc C, Lo-Man R.
Sci Transl Med. 2014 May 28;6(238):238ra72. doi: 10.1126/scitranslmed.3008748.

Induction of CD8+ T-cell responses against subunit antigens by the novel cationic liposomal CAF09 adjuvant.
Korsholm KS, Hansen J, Karlsen K, Filskov J, Mikkelsen M, Lindenstrøm T, Schmidt ST, Andersen P, Christensen D.
Vaccine. 2014 May 28. pii: S0264-410X(14)00726-9. doi: 10.1016/j.vaccine.2014.05.050. [Epub ahead of print]

Plasmacytoid Dendritic Cells Engagement by Influenza Vaccine as a Surrogate Strategy for Driving T-Helper Type 1 Responses in Human Neonatal Settings.
Zhang X, Casartelli N, Lemoine S, Mozeleski B, Azria E, Le Ray C, Schwartz O, Launay O, Leclerc C, Lo-Man R.
J Infect Dis. 2014 Mar 21. [Epub ahead of print]

Progress in tuberculosis vaccine development and host-directed therapies-a state of the art review.
Kaufmann SH, Lange C, Rao M, Balaji KN, Lotze M, Schito M, Zumla AI, Maeurer M.
Lancet Respir Med. 2014 Apr;2(4):301-320. doi: 10.1016/S2213-2600(14)70033-5. Epub 2014 Mar 24.

The BCG replacement vaccine VPM1002: from drawing board to clinical trial.
Kaufmann SH, Cotton MF, Eisele B, Gengenbacher M, Grode L, Hesseling AC, Walzl G.
Expert Rev Vaccines. 2014 May;13(5):619-30. doi: 10.1586/14760584.2014.905746. Epub 2014 Apr 7.

Tuberculosis vaccine development at a divide.
Kaufmann SH.
Curr Opin Pulm Med. 2014 May;20(3):294-300. doi: 10.1097/MCP.0000000000000041.

Recent advances towards tuberculosis control: vaccines and biomarkers (Review).
Weiner 3rd J, Kaufmann SHE Max Planck Institute for Infection Biology, Berlin, Germany.
J Intern Med 2014; 275: 467–480.

Challenges and responses in human vaccine development.
Kaufmann SH, Juliana McElrath M, Lewis DJ, Del Giudice G.
Curr Opin Immunol. 2014 Feb 18;28C:18-26. doi: 10.1016/j.coi.2014.01.009. [Epub ahead of print]

Fusion of HCV Nonstructural Antigen to MHC Class II-associated Invariant Chain Enhances T-cell Responses Induced by Vectored Vaccines in Nonhuman Primates.
Capone S, Naddeo M, D’Alise AM, Abbate A, Grazioli F, Del Gaudio A, Del Sorbo M, Esposito ML, Ammendola V, Perretta G, Taglioni A, Colloca S, Nicosia A, Cortese R, Folgori A.
Mol Ther. 2014 Jan 30. doi: 10.1038/mt.2014.15. [Epub ahead of print]

Reverse translation in tuberculosis: neutrophils provide clues for understanding development of active disease
Anca Dorhoi, Marco Iannaccone, Jeroen Maertzdorf, Geraldine Nouailles, January Weiner 3rd and Stefan H. E. Kaufmann
Front. Immunol., 05 February 2014 | doi: 10.3389/fimmu.2014.00036

Tuberculosis vaccine with high predicted population coverage and compatibility with modern diagnostics.
Knudsen NP, Nørskov-Lauritsen S, Dolganov GM, Schoolnik GK, Lindenstrøm T, Andersen P, Agger EM, Aagaard C.
Proc Natl Acad Sci U S A. 2014 Jan 6. [Epub ahead of print]