Publications in 2016

Publications in 2016

Human isotype-dependent inhibitory antibody responses against Mycobacterium tuberculosis. 
Zimmermann, N; Thormann, V; Hu, B; Kohler, AB; Imai-Matsushima, A; Locht, C; Arnett, E; Schlesinger, LS; Zoller, T; Schurmann, M; Kaufmann, SHE; Wardemann, H, EMBO Molecular Medicine (2016) doi: 10.15252/emmm.201606330

Anticipating policy considerations for a future HIV vaccine: a preliminary study.
Williams, EA; Lewis, DJM; Bertholet, S; Zazzi, M.  Vaccine (2016) doi: 10.1016/j.vaccine.2016.03.086

Circulating Gut-Homing (alpha(4)beta(+)(7)) Plasmablast Responses against Shigella Surface Protein Antigens among Hospitalized Patients with Diarrhea.
Sinha, A; Dey, A; Saletti, G; Samanta, P; Chakraborty, PS; Bhattacharya, MK; Ghosh, S; Ramamurthy, T; Kim, JO; Yang, JS; Kim, DW; Czerkinsky, C; Nandy, RK. Clinical and Vaccine Immunology (2016) doi: 10.1128/CVI.00205-16

Mucosal BCG vaccination induces protective lung resident memory T cell populations against Tuberculosis.
Perdomo C. Zedler U., kuhl A, Lozza L, Saikali P, Sander L, Vogelzang A, Kaufmann S,  Kupz A. American Society for Microbiology (2016)  November doi: 10.1128/mBio.01686-16

KLRG1 and PD-1 expression are increased on T-cells following tuberculosis-treatment and identify cells with different proliferative capacities in BCG-vaccinated adults.
Boer, MC; van Meijgaarden, KE; Goletti, D; Vanini, V; Prins, C; Ottenhoff, THM; Joosten, SA. Tuberculosis (2016) doi: 10.1016/

Impairment of CCR6+ and CXCR3+ Th Cell migration in HIV-1 infection is rescued by modulating actin polymerization.
Cecchinato V, Bernasconi E, Speck R, Proietti M, Sauermann U, D’Agostino G, denelon G, Rezzonico Jost T, Grassi F, Raeli L, Schoeni-Affolter F, Stahl-Hennig C, Uguccioni M. Journal of Immunology (2016) doi: 10.4049/jimmunol.16005688

High-throughput and computational approaches for diagnostic and prognostic host tuberculosis biomarkers.
January Weiner and Stefan H.E. Kaufmann. International Journal of Infectious Diseases (2016),

Novel approaches to TB vaccine development.
Stefan H.E. Kaufmann, January Weiner, C. Fordham von Reyn. International Journal of Infectious Diseases (2016),

Expression and function of IL-1R8 (TIR8/SIGIRR): a regulatory member of the IL-1 receptor family in platelets.
Anselmo A, Riva F, Gentile S, Soldani C, Barbagallo M, Mazzon C, Feruglio F, Polentarutti N, Somma P, Carullo P, Angelini C, Bacci M, Mendolicchio GL, Voza A, Nebuloni M, Mantovani A, Garlanda C. Cardiovasc Res. 2016 Sep;111(4):373-84.

Intramuscular Immunisation with Chlamydial Proteins Induces Chlamydia trachomatis Specific Ocular Antibodies.
Alexander Badamchi-Zadeh, Paul F McKay, Martin J Holland, Wayne Paes, Andrzej Brzozowski, Charles Lacey, Frank Follmann, John S Tregoning, Robin J Shattock. PloS One 2015.

A Multi-Component Prime-Boost Vaccination Regimen with a Consensus MOMP Antigen Enhances Chlamydia trachomatis Clearanc.
Badamchi-Zadeh A, McKay PF, Korber BT, et al. Frontiers in immunology 2016; 7: 162.

Multicriteria decision analysis and core values for enhancing vaccine-related decision-making.
Badamchi-Zadeh A, McKay PF, Korber BT, et al. A4. Barocchi Michèle A., Black Steve, Rappuoli Rino. Science Translational Medicine (2016) June 29 doiI: 10.1126/scitranslmed.aaf0756.

Testing the H56 Vaccine Delivered in 4 Different Adjuvants as a BCG-Booster in a Non-Human Primate Model of Tuberculosis.
Billeskov R, Tan EV, Cang M, Abalos RM, Burgos J, Pedersen BV, Christensen D, Agger EM, Andersen P.  PLoS One. 2016 Aug 15;11(8):e0161217. doi: 10.1371/journal.pone.0161217. eCollection 2016.

Vascular pentraxin 3 controls arterial thrombosis by targeting collagen and fibrinogen induced platelets aggregation.
Bonacina F, Barbieri SS, Cutuli L, Amadio P, Doni A, Sironi M, Tartari S, Mantovani A, Bottazzi B, Garlanda C, Tremoli E, Catapano AL, Norata GD. Biochim Biophys Acta. 2016, 1862:1182-90. doi: 10.1016/j.bbadis.2016.03.007. PubMed PMID: 26976330.

The pentraxins PTX3 and SAP in innate immunity, regulation of inflammation and tissue remodelling.
Bottazzi B, Inforzato A, Messa M, Barbagallo M, Magrini E, Garlanda C, Mantovani A. J Hepatol. 2016, 64:1416-1427. doi: 10.1016/j.jhep.2016.02.029.. PubMed PMID: 26921689.

Vaccine-induced TH17 cells are established as resident memory cells in the lung and promote local IgA responses.
Christensen D, Mortensen R, Rosenkrands I, Dietrich J, Andersen P. Mucosal Immnology. (2016) April 6;  doi: 10.1038/mi.2016.28

Modulation of Primary immune response by Different Vaccine adjuvants
Annalisa Ciabattini1*, Elena Pettini1, Fabio Fiorino1, Gabiria Pastore1, Peter Andersen2, Gianni Pozzi1 and Donata Medaglini1*

Neutropenia as an Adverse Event following Vaccination: Results from Randomized Clinical Trials in Healthy Adults and Systematic Review
Muturi-Kioi et al._PLoS ONE 2016

ESAT-6-dependent cytosolic pattern recognition is essential for non-cognate, IL-18-driven, IFN-γ-mediated in vivo control of tuberculosis.
Kupz, A., U. Zedler, M. Stäber, C. Perdomo, A. Dorhoi, R. Brosch, S.H.E. Kaufmann
J Clin Invest. 2016. doi:10.1172/JCI84978.

Evaluation of polylactic acid nanoparticles safety using Drosophila model.
Legaz S, Exposito JY, Lethias C, Viginier B, Terzian C, Verrier B.
Nanotoxicology. 2016 Oct;10(8):1136-43. doi: 10.1080/17435390.2016.1181806. Epub 2016 May 16.

Booster vaccination against tetanus and diphtheria: insufficient protection against diphtheria in young and elderly adults.
Grasse M, Meryk A, Schirmer M, Grubeck-Loebenstein B, Weinberger 1.
Immun Ageing. 2016 Sep 5;13(1):26. eCollection 2016.

Deletion of nuoG from the Vaccine Candidate Mycobacterium bovis BCG ΔureC::hly Improves Protection against Tuberculosis.
Gengenbacher M1, Nieuwenhuizen N2, Vogelzang A2, Liu H2, Kaiser P2, Schuerer S, Lazar D, Wagner I, Mollenkopf HJ, Kaufmann SH.
MBio. 2016 May 24;7(3). pii: e00679-16.

Trehalose diester glycolipids are superior to the monoesters in binding to Mincle, activation of macrophages in vitro and adjuvant activity in vivo.
Huber A, Kallerup RS, Korsholm KS, Franzyk H, Lepenies B, Christensen D, Foged C, Lang R.
Innate Immun. 2016 Aug;22(6):405-18.

Fluid phase recognition molecules in neutrophil-dependent immune responses.
Jaillon S, Ponzetta A, Magrini E, Barajon I, Barbagallo M, Garlanda C, Mantovani A.
Semin Immunol. 2016 Apr;28(2):109-18.

Patients with Tuberculosis Have a Dysfunctional Circulating B-Cell Compartment, Which Normalizes following Successful Treatment.
Joosten SA, van Meijgaarden KE, Del Nonno F, Baiocchini A, Petrone L, Vanini V, Smits HH, Palmieri F, Goletti D, Ottenhoff TH.
PLoS Pathog. 2016 Jun 15;12(6):e1005687.

Non‐glycosidic compounds can stimulate both human and mouse iNKT cells.
John‐Paul Jukes, Uzi Gileadi, Hemza Ghadbane, Ting‐Fong Yu, Dawn Shepherd, Liam R. Cox, Gurdyal S. Besra, 2 and Vincenzo Cerundolo
Eur J Immunol. 2016 May; 46(5): 1224–1234.

TB biomarkers, TB correlates and human challenge models: New tools for improving assessment of new TB vaccines.
Kaufmann SH, Fortune S, Pepponi I, Ruhwald M, Schrager LK, Ottenhoff TH.
Tuberculosis (Edinb). 2016 Aug;99 Suppl 1:S8-S11.

A Mouse Model of Latent Tuberculosis Infection to Study Intervention Strategies to Prevent Reactivation
Andreas Kupz, Ulrike Zedler, Manuela Stäber and Stefan H. E. Kaufmann.
PLoS One. 2016; 11(7): e0158849.

DNA Vaccines Encoding Antigen Targeted to MHC Class II Induce Influenza-Specific CD8(+) T Cell Responses, Enabling Faster Resolution of Influenza Disease.
Lambert L, Kinnear E, McDonald JU, Grodeland G, Bogen B, Stubsrud E, Lindeberg MM, Fredriksen AB, Tregoning JS.
Front Immunol. 2016 Aug 23;7:321.

Directing vaccine immune responses to mucosa by nanosized particulate carriers encapsulating NOD ligands.
Pavot V, Climent N, Rochereau N, Garcia F, Genin C, Tiraby G, Vernejoul F, Perouzel E, Lioux T, Verrier B, Paul S.
Biomaterials. 2016 Jan;75:327-39.

Modulation of Chemokine Responses: Synergy and Cooperativity.
Proudfoot AE, Uguccioni M.
Front Immunol. 2016 May 19;7:183.

Aging of the immune system: Focus on inflammation and vaccination.
Pinti M, Appay V, Campisi J, Frasca D, Fülöp T, Sauce D, Larbi A, Weinberger B, Cossarizza A.
Eur J Immunol. 2016 Oct;46(10):2286-2301.

CD8(+) T cells of Listeria monocytogenes-infected mice recognize both linear and spliced proteasome products.
Platteel AC, Mishto M, Textoris-Taube K, Keller C, Liepe J, Busch DH, Kloetzel PM, Sijts AJ.
Eur J Immunol. 2016 May;46(5):1109-18.

Strategies to enhance immunogenicity of cDNA vaccine encoded antigens by modulation of antigen processing.
Platteel AC, Marit de Groot A, Keller C, Andersen P, Ovaa H, Kloetzel PM, Mishto M, Sijts AJ.
Vaccine. 2016 Sep 30;34(42):5132-40.

Use of the Microparticle Nanoscale Silicon Dioxide as an Adjuvant To Boost Vaccine Immune Responses against Influenza Virus in Neonatal Mice.
Russell RF, McDonald JU, Lambert L, Tregoning JS.
J Virol. 2016 Apr 14;90(9):4735-44.

Triggering Intracellular Receptors for Vaccine Adjuvantation.
Gutjahr A, Tiraby G, Perouzel E, Verrier B, Paul S.
Trends Immunol. 2016 Sep;37(9):573-87.

The Effect of Cellular Stress on T and B Cell Memory Pathways in Immunized and Unimmunized BALB/c Mice.
Wang Y, Rahman D, Mistry M, Lehner T.
J Biol Chem. 2016 Sep 23;291(39):20707-17.

Adult vaccination against tetanus and diphtheria: the European perspective.
Weinberger B.
Clin Exp Immunol. 2016 Jun 9.

Subunit vaccine H56/CAF01 induces a population of circulating CD4 T cells that traffic into the Mycobacterium tuberculosis-infected lung.
Woodworth JS, Cohen SB, Moguche AO, Plumlee CR, Agger EM, Urdahl KB, Andersen P.
Mucosal Immunol. 2016 Aug 24.

Syndecans promote mycobacterial internalization by lung epithelial cells.
Zimmermann N, Saiga H, Houthuys E, Moura-Alves P, Koehler A, Bandermann S, Dorhoi A, Kaufmann SH.
Cell Microbiol. 2016 Dec;18(12):1846-1856.

A blood RNA signature for tuberculosis disease risk: a prospective cohort study.
Zak DE, Penn-Nicholson A, Scriba TJ, Thompson E, Suliman S, Amon LM, Mahomed H, Erasmus M, Whatney W, Hussey GD, Abrahams D, Kafaar F, Hawkridge T, Verver S, Hughes EJ, Ota M, Sutherland J, Howe R, Dockrell HM, Boom WH, Thiel B, Ottenhoff TH, Mayanja-Kizza H, Crampin AC, Downing K, Hatherill M, Valvo J, Shankar S, Parida SK, Kaufmann SH, Walzl G, Aderem A, Hanekom WA; ACS and GC6-74 cohort study groups.
Lancet. 2016 Mar 23. pii: S0140-6736(15)01316-1. doi: 10.1016/S0140-6736(15)01316-1.

Vaccine-induced Th17 cells are established as resident memory cells in the lung and promote local IgA responses.
Mucosal Immunol. 2016 Apr 6. doi: 10.1038/mi.2016.28.
Christensen D, Mortensen R, Rosenkrands I, Dietrich J, Andersen P.

Vaccination in early life: standing up to the challenges
Elodie Mohr, Claire-Anne Siegrist
Opinion in Immunology, Volume 41, August 2016, Pages 1–8 doi:10.1016/j.coi.2016.04.004

Reverse vaccinology 2.0: Human immunology instructs vaccine antigen design.
Rappuoli R, Bottomley MJ, D’Oro U, Finco O, De Gregorio E.
J Exp Med. 2016 Apr 4;213(4):469-81. doi: 10.1084/jem.20151960. Epub 2016 Mar 28.

Molecular Determinants in Phagocyte-Bacteria Interactions.
Kaufmann SH, Dorhoi A.
Immunity. 2016 Mar 15;44(3):476-91. doi: 10.1016/j.immuni.2016.02.014.

Pathology and immune reactivity: understanding multidimensionality in pulmonary tuberculosis.
Dorhoi A, Kaufmann SH.
Semin Immunopathol. 2016 Mar;38(2):153-66. doi: 10.1007/s00281-015-0531-3. Epub 2015 Oct 5.

Systems vaccinology informs influenza vaccine immunogenicity.
García-Sastre A.
Proc Natl Acad Sci U S A. 2016 Feb 16;113(7):1689-91. doi: 10.1073/pnas.1525361113. Epub 2016 Feb 3.

Reprogramming the T Cell Response to Tuberculosis
Joshua S. Woodworth, Peter Andersen
Cell, DOI:

Human Circulating Antibody-Producing B Cell as a Predictive Measure of Mucosal Immunity to Poliovirus.
Dey A, Molodecky NA, Verma H, Sharma P, Yang JS, Saletti G, Ahmad M, Bahl SK, Wierzba TF, Nandy RK, Deshpande JM, Sutter RW, Czerkinsky C.
PLoS One. 2016 Jan 5;11(1):e0146010. doi: 10.1371/journal.pone.0146010. eCollection 2016.

Different human vaccine adjuvants promote distinct antigen-independent immunological signatures tailored to different pathogens
Niels Peter H. Knudsen, Anja Olsen, Cecilia Buonsanti, Frank Follmann, Yuan Zhang, Rhea N. Coler, Christopher B. Fox, Andreas Meinke, Ugo D´Oro, Daniele Casini, Alessandra Bonci, Rolf Billeskov, Ennio De Gregorio, Rino Rappuoli, Ali M. Harandi, Peter Andersen & Else Marie Agger
Nature Scientific Reports 21 January 2016, doi:10.1038/srep19570

Systems biology of immunity to MF59-adjuvanted versus non-adjuvanted trivalent seasonal influenza vaccines in early childhood
Helder I Nakaya, Elizabetth Clutterbuck, Dmitri Kazmin, Lili Wang, Mario Cortese, Steven E Bosinger, Nirav B, Patel, Daniel E Zak, Alan Aderem, Tao Dong, Giuseppe Del Giudice, Rino Rappuoli , Vincenzo Cerundolo, Andrew J Pollard, Bali Pulendran, Claire-Anne Siegrist
Proc Natl Acad Sci U S A. January 11, 2016, doi: 10.1073/pnas.1519690113