The first report on comparative systems biology analysis of these four adjuvants was produced. The results of whole genome transcriptional analysis unrevealed common and unique molecular pathways and cellular responses induced by the different human adjuvants that could inform rational vaccine design.
This is the first extensive attempt to categorize clinical-grade adjuvants based on their immune profiles, protective efficacy and systems biology analysis to inform a rational development of next generation vaccines for human use.
Data are published in:Olafsdottir T, et al. Nature Sci. Rep. 2016.
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