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Scientific publications

Publications 2019

  1. Arrey F, Löwe D, Kuhlmann S, Kaiser P, Moura-Alves P, Krishnamoorthy G, Lozza L, Maertzdorf J, Skrahina T, Skrahina A, Gengenbacher M, Nouailles G, Kaufmann SHE. Humanized Mouse Model Mimicking Pathology of Human Tuberculosis for in vivo Evaluation of Drug Regimens. Front Immunol. 2019; 10:89. doi.org/10.3389/fimmu.2019.00089
  2. Blakney AK, McKay PF, Christensen D, Yus Bl, Aldon Y, Follmann F, Shattock RJ: Effects of cationic adjuvant formulation particle type, fluidity and immunomodulators on delivery and immunogenicity of saRNA. J Control Release, 2019; 304:65-74. doi: 10.1016/j.jconrel.2019.04.043
  3. Christensen D, Bøllehuus Hansen L, Leboux R, Jiskoot W, Christensen JP, Andersen P, Dietrich J. A Liposome-Based Adjuvant Containing Two Delivery Systems with the Ability to Induce Mucosal Immunoglobulin A Following a Parenteral Immunization. ACS Nano, 2019;13(2):1116-1126. doi.org/10.1021/acsnano.8b05209
  4. Ciabattini A, Olivieri R, Lazzeri E, Medaglini D. Role of the Microbiota in the Modulation of Vaccine Immune Responses. Front Microbiol. 2019 Jul 3;10:1305. doi: 10.3389/fmicb.2019.01305. eCollection 2019
  5. Cousin C, Oberkampf M, Felix T, Rosenbaum P, Weil R, Fabrega S, Morante V, Negri D, Cara A, Dadaglio G, Leclerc C. Persistence of Integrase-Deficient Lentiviral Vectors Correlates with the Induction of STING-Independent CD8+ T Cell Responses. Cell Rep. 2019; 26(5):1242-1257.e7. doi: 10.1016/j.celrep.2019.01.025
  6. Duffy FJ, Weiner J 3rd, Hansen S, Tabb DL, Suliman S, Thompson E, Maertzdorf J, Shankar S, Tromp G, Parida S, Dover D, Axthelm MK, Sutherland JS, Dockrell HM, Ottenhoff THM, Scriba TJ, Picker LJ, Walzl G, Kaufmann SHE, Zak DE; GC6-74 Consortium. Immunometabolic signatures predict risk of progression to active tuberculosis and disease outcome. Front Immunol. 2019 Mar 22;10:527. doi: 10.3389
  7. Mastelic-Gavillet B, Vono M, Gonzalez-Dias P, Ferreira MF, Cardozo L, Lambert PH, Nakaya H and Siegrist CA. Neonatal T follicular helper cells are lodged in a pre-T follicular helper stage favoring innate over adaptive germinal center responses. Front Immunol. 2019 13;10:1845. doi: 10.3389/fimmu.2019.01845
  8. Pastore G, Carraro M, Pettini E, Nolfi E, Medaglini D and Ciabattini A. Optimized protocol for the detection of multifunctional epitope-specific CD4+ T cells combining MHC-II tetramer and intracellular cytokine staining technologies. In Revision in Frontiers in Immunology
  9. Rappuoli R, Santoni A & Mantovani A. Vaccines: An achievement of civilization, a human right, our health insurance for the future. J Exp Med. 2019; 216(1):7-9. doi: 10.1084/jem.20182160
  10. Riccomi A, Piccaro G, Christensen D, Palma C, Andersen P and Vendetti S, Parenteral vaccination with a tuberculosis subunit vaccine in presence of retinoic acid provides early but transient protection to M. tuberculosis infection, Front. Immunol. 2019. doi.org/10.3389/fimmu.2019.00934
  11. Tandrup Schmidt S, Line Olsen C, Franzyk H, Wørzner K, Smith Korsholm K, Rades T, Andersen P, Foged C, Christensen D: Comparison of two different PEGylation strategies for the liposomal adjuvant CAF09: Towards induction of CTL responses upon subcutaneous vaccine administration. Eur J Pharm Biopharm, 2019; 140:29-39. doi: 10.1016/j.ejpb.2019.04.020
  12. Vono M, Eberhardt CS, Auderset F, Mastelic-Gavillet B, Lemeille S, Christensen D, Peter Andersen P, Lambert PH and Siegrist CA. Maternal antibodies inhibit neonatal and infant responses to vaccination by shaping the early life B cell repertoire within germinal centers. Cell Rep. 2019; 13;28(7):1773-1784.e5. doi: 10.1016/j.celrep.2019.07.047
  13. Woodworth JS, Christensen D, Cassidy JP, Agger EM, Mortensen R, Andersen P. Mucosal boosting of H56:CAF01 immunization promotes lung-localized T cells and an accelerated pulmonary response to Mycobacterium tuberculosis infection without enhancing vaccine protection. Mucosal Immunol. 2019 ;12(3):816-826. doi: 10.1038/s41385-019-0145-5.
  14. Zhong Z, Haltalli M, Holder B, Rice T, Donaldson B, O’Driscoll M, Le-Doare K, Kampmann B, Tregoning JS. The impact of timing of maternal influenza immunization on infant antibody levels at birth. Clin Exp Immunol. 2019 Feb;195(2):139-152. doi: 10.1111/cei.13234.

Publications 2018

  1. Ahsan F, Maertzdorf J, Guhlich-Bornhof U, Kaufmann SHE, Moura-Alves P. IL-36/LXR axis modulates cholesterol metabolism and immune defense to Mycobacteriumtuberculosis. Sci Rep. 2018 Jan 24;8(1):1520. doi: 10.1038/s41598-018-19476-x.
  2. Alter G, Ottenhoff THM, Joosten SA. Antibody glycosylation in inflammation, disease and vaccination. Semin Immunol. 2018 Jun 11. pii: S1044-5323(18)30006-X. doi: 10.1016/j.smim.2018.05.003.
  3. Anderson J., Olafsdottir T.A., Östensson M., Kratochvil S., Persson J., McKay P. F., Shattock R.J., Harandi A.M., Molecular signatures of a TLR4 agonist-adjuvanted HIV-1 vaccine candidate in humans. Front. Immunol. 2018 Feb 26;9:301 doi: 10.3389/fimmu.2018.00301. eCollection 2018.
  4. Baldwin S.L., Hsu F., Van Hoeven N., Gage E., Granger B., Guderian J.A., Larsen S.E., Lorenzo E.C., Haynes L., Reed S.G., Coler R.N., Improved Immune Responses in Young and Aged Mice with Adjuvanted Vaccines against H1N1 Influenza Infection. Front Immunol. 2018 Feb 19;9:295. doi: 10.3389/fimmu.2018.00295. eCollection 2018.
  5. Cecchinato V, D’Agostino G, Raeli L, Nerviani A, Schiraldi M, Danelon G, Manzo A, Thelen M, Ciurea A, Bianchi ME, Rubartelli A, Pitzalis C, Uguccioni M. Redox-mediated mechanisms fuel monocyte responses to CXCL12/HMGB1 in active Rheumatoid Arthritis. Front Immunol. 2018; 19;9:2118. doi: 10.3389/fimmu.2018.02118.
  6. Cecchinato V, Uguccioni M. Insight on the regulation of chemokine activities. J Leukoc Biol. 2018 Aug;104(2):295-300. doi: 10.1002/JLB.3MR0118-014R. Epub 2018 Apr 18.
  7. Ciabattini A, Nardini C, Santoro F, Gragnani P, Franceschi C, Medaglini D. Vaccination in the elderly: the challenge of immune changes with aging. Semin Immunol. 2018;40:83-94. doi: 10.1016/j.smim.2018.10.010.
  8. Ciabattini A., Pettini E., Fiorino F., Lucchesi S., Pastore G., Brunetti J., Santoro F., Andersen P., Bracci L., Pozzi G., Medaglini D., Heterologous prime-boost combinations highlight the crucial role of adjuvant in priming the immune system. Front. Immunol. 2018 Mar 12;9:380. doi: 10.3389/fimmu.2018.00380. eCollection 2018.
  9. Ciabattini A, Nardini C, Santoro F, Garagnani P, Franceschi C, Medaglini D. Vaccination in the elderly: The challenge of immune changes with aging. Semin Immunol. 2018; 40:83-94. doi: 10.1016/j.smim.2018.10.010.
  10. Coppola M, van den Eeden SJF, Robbins N, Wilson L, Franken KLMC, Adams LB, Gillis TP, Ottenhoff THM, Geluk A. Vaccines for Leprosy and Tuberculosis: Opportunities for Shared Research, Development, and Application. Front Immunol. 2018 Feb 26;9:308. doi: 10.3389/fimmu.2018.00308. eCollection 2018.
  11. Duffy FJ, Thompson E, Downing K, Suliman S, Mayanja-Kizza H, Boom WH, Thiel B, Weiner Iii J, Kaufmann SHE, Dover D, Tabb DL, Dockrell HM, Ottenhoff THM, Tromp G, Scriba TJ, Zak DE, Walzl G; GC6-74 Consortium. A Serum Circulating miRNA Signature for Short-Term Risk of Progression to Active Tuberculosis Among Household Contacts. Front Immunol. 2018 Apr 13;9:661. doi: 10.3389/fimmu.2018.00661. eCollection 2018.
  12. Gallinaro A., Borghi M., Bona R., Michelini Z., Grasso F. , Calzoletti L., Palladino L., Cecchetti S., Vescio M.F., Macchia D., Morante V., Canitano A., Temperton N., Maria Rita Castrucci M.R., Salvatore M., Cara A., Negri D., Integrase defective lentiviral vector as a vaccine platform for delivering Influenza antigens. Front Immunol. 2018 Feb 5;9:171. doi: 10.3389/fimmu.2018.00171. eCollection 2018.
  13. Garlanda C, Bottazzi B, Magrini E, Inforzato A, Mantovani A. PTX3, a Humoral Pattern Recognition Molecule, in Innate Immunity, Tissue Repair, and Cancer. Physiol Rev. 2018 Apr 1;98(2):623-639. doi: 10.1152/physrev.00016.2017.
  14. Gebremicael G, Kassa D, Quinten E, Alemayehu Y, Gebreegziaxier A, Belay Y, van Baarle D, Ottenhoff THM, Cliff JM, Haks MC. Host gene expression kinetics during treatment of tuberculosis in HIV-coinfected individuals is independent of HAART therapy. J Infect Dis. 2018 Jul 2. doi: 10.1093/infdis/jiy404.
  15. Goletti D, Lee MR, Wang JY, Walter N, Ottenhoff THM. Update on tuberculosis biomarkers: From correlates of risk, to correlates of active disease and of cure from disease. Respirology. 2018 May;23(5):455-466. doi: 10.1111/resp.13272. Epub 2018 Feb 18.
  16. Grasse M., Rosenkrands I., Olsen A., Follmann F., Dietrich J. A flow cytometry-based assay to determine the phagocytic activity of both clinical and nonclinical antibody samples against Chlamydia trachomatis. Cytometry A 2018;93(5):525-532. doi: 10.1002/cyto.a.23353
  17. Groves H.T., McDonald J., Langat P., KinnearE., Kellam P., Thompson C., Ellis J., JMcCauley J., Elderfield R., Parker L., Barclay W., Tregoning J.S., Mouse models of influenza infection with circulating strains to test efficacy of seasonal vaccines. Front Immunol. 2018 Jan 31;9:126. doi: 10.3389/fimmu.2018.00126. eCollection 2018.
  18. Groves H.T., Cuthbertson L., James P., Moffatt M., Cox M., Tregoning J.S., Respiratory disease following viral lung infection alters the murine gut microbiota. Front Immunol. 2018 Feb 12;9:182. doi: 10.3389/fimmu.2018.00182. eCollection 2018.
  19. Johnson JS, Lucas SY, Amon LM, Skelton S, Nazitto R, Carbonetti S, Sather DN, Littman DR, Aderem A. Reshaping of the Dendritic Cell Chromatin Landscape and Interferon Pathways during HIV Infection. Cell Host Microbe. 2018 Mar 14;23(3):366-381.e9. doi: 10.1016/j.chom.2018.01.012.
  20. Joosten SA, van Meijgaarden KE, Arend SM, Prins C, Oftung F, Korsvold GE, Kik SV, Arts RJ4, van Crevel R, Netea MG, Ottenhoff TH. Mycobacterial growth inhibition is associated with trained innate immunity. J Clin Invest. 2018 May 1;128(5):1837-1851. doi: 10.1172/JCI97508. Epub 2018 Apr 3.
  21. Korbee CJ, Heemskerk MT, Kocev D, van Strijen E, Rabiee O, Franken KLMC, Wilson L, Savage NDL, Džeroski S, Haks MC, Ottenhoff THM. Combined chemical genetics and data-driven bioinformatics approach identifies receptor tyrosine kinase inhibitors as host-directed antimicrobials. Nat Commun. 2018 Jan 24;9(1):358. doi: 10.1038/s41467-017-02777-6.
  22. Hansen SG, Zak DE, Xu G, Ford JC, Marshall EE, Malouli D, Gilbride RM, Hughes CM, Ventura AB, Ainslie E, Randall KT, Selseth AN, Rundstrom P, Herlache L, Lewis MS, Park H, Planer SL, Turner JM, Fischer M, Armstrong C, Zweig RC, Valvo J, Braun JM, Shankar S, Lu L, Sylwester AW, Legasse AW, Messerle M, Jarvis MA, Amon LM, Aderem A, Alter G, Laddy DJ, Stone M, Bonavia A, Evans TG, Axthelm MK, Früh K, Edlefsen PT, Picker LJ. Prevention of tuberculosis in rhesus macaques by a cytomegalovirus-based vaccine. Nat Med. 2018 Feb;24(2):130-143. doi: 10.1038/nm.4473. Epub 2018 Jan 15.
  23. Lambert PH, Podda A. Education in Vaccinology: An Important Tool for Strengthening Global Health. Front Immunol. 2018 May 24;9:1134. doi: 10.3389/fimmu.2018.01134. eCollection 2018.
  24. Nieuwenhuizen N.E., Kaufmann S.H.E., Next Generation Vaccines Based on BCG. Front Immunol. 2018 Feb 5;9:121. doi: 10.3389/fimmu.2018.00121. eCollection 2018.
  25. Orlando V, La Manna MP, Goletti D, Palmieri F, Lo Presti E, Joosten SA, La Mendola C, Buccheri S, Ottenhoff THM, Dieli F, Caccamo N. Human CD4 T-Cells With a Naive Phenotype Produce Multiple Cytokines During Mycobacterium Tuberculosis Infection and Correlate With Active Disease. Front Immunol. 2018 May 23;9:1119. doi: 10.3389/fimmu.2018.01119. eCollection 2018.
  26. Ottenhoff THM. Correlates of vaccine adjuvanticity, vaccine activity, protective immunity and disease in human infectious disease and cancer. Semin Immunol. 2018 Oct;39:1-3. doi: 10.1016
  27. Prezzemolo T, van Meijgaarden KE, Franken KLMC, Caccamo N, Dieli F, Ottenhoff THM, Joosten SA. Detailed characterization of human Mycobacterium tuberculosis specific HLA-E restricted CD8+ T cells. Eur J Immunol. 2018 Feb;48(2):293-305. doi: 10.1002
  28. Pedersen GK, Andersen P, Christensen D: Immunocorrelates of CAF family adjuvants. Sermin Immunol, 2018; 39:4-13. doi: 10.1016/j.smim.2018.10.003
  29. Santoro F, Pettini E, Kazmin D, Ciabattini A, Fiorino F, Gilfillan GD, Evenroed IM, Andersen P, Pozzi G, Medaglini D. Transcriptomics of the Vaccine Immune Response: Priming With Adjuvant Modulates Recall Innate Responses After Boosting. Front Immunol. 2018 Jun 5;9:1248. doi: 10.3389/fimmu.2018.01248. eCollection 2018.
  30. Suliman S, Thompson E, Sutherland J, Weiner Rd J, Ota MOC, Shankar S, Penn-Nicholson A, Thiel B, Erasmus M, Maertzdorf J, Duffy FJ, Hill PC, Hughes EJ, Stanley K, Downing K, Fisher ML, Valvo J, Parida SK, van der Spuy G, Tromp G, Adetifa IMO, Donkor S, Howe R, Mayanja-Kizza H, Boom WH, Dockrell H, Ottenhoff THM, Hatherill M, Aderem A, Hanekom WA, Scriba TJ, Kaufmann SH, Zak DE, Walzl G; and the GC6-74 and ACS cohort study groups. Four-gene Pan-African Blood Signature Predicts Progression to Tuberculosis. Am J Respir Crit Care Med. 2018 Apr 6. doi: 10.1164/rccm.201711-2340OC.
  31. Thompson EG, Shankar S, Gideon HP, Braun J, Valvo J, Skinner JA, Aderem A, Flynn JL, Lin PL, Zak DE. Prospective Discrimination of Controllers From Progressors Early After Low-Dose Mycobacterium tuberculosis Infection of Cynomolgus Macaques using Blood RNA Signatures. J Infect Dis. 2018 Mar 28;217(8):1318-1322. doi: 10.1093/infdis/jiy006.
  32. Tulli L., Cattaneo F., Vinot J., Baldari C.T., D’Oro U., Src family kinases regulate IRF-1 K63 ubiquitination following activation by TLR7/8 vaccine adjuvant in human monocytes and B cells. Front Immunol. 2018 Mar 1;9:330. doi: 10.3389/fimmu.2018.00330. eCollection 2018.
  33. Weiner J 3rd, Mohney RP, Kaufmann SHE. The potential of metabolic profiling for vaccine development. Semin Immunol. 2018 Jul 19. pii: S1044-5323(18)30027-7. doi: 10.1016/j.smim.2018.07.002. Review.
  34. Vrieling F, Ronacher K, Kleynhans L, van den Akker E, Walzl G, Ottenhoff THM, Joosten SA. Patients with Concurrent Tuberculosis and Diabetes Have a Pro-Atherogenic Plasma Lipid Profile. EBioMedicine. 2018 Jun;32:192-200. doi: 10.1016/j.ebiom.2018.05.011. Epub 2018 May 17.
  35. Vo H.T.M., Baudner B., Sammicheli S., Iannacone M., D’Oro U., Piccioli D., Alum/TLR7 adjuvant enhances the expansion of memory B cell compartment within the draining lymph node. Front. Immunol., 09 April 2018, https://doi.org/10.3389/fimmu.2018.00641
  36. Vono M., Eberhardt C.S., Elodie Mohr, Auderset F., Schmolke M., Christensen D., Coler R., Meinke A., Andersen P., Lambert P., Mastelic-Gavillet B., Siegrist C.A., Overcoming the Neonatal Limitations of Inducing Germinal Centers through Liposome-based Adjuvants including C-type Lectin Agonists Trehalose Dibehenate or Curdlan. Front Immunol. 2018 Feb 28;9:381. doi: 10.3389/fimmu.2018.00381. eCollection 2018.
  37. Weinberger B. Adjuvant strategies to improve vaccination of the elderly population. Curr Opin Pharmacol. 2018 Aug;41:34-41. doi: 10.1016/j.coph.2018.03.014. Epub 2018 Apr 17.
  38. Weinberger B, Haks MC, de Paus RA, Ottenhoff THM, Bauer T, Grubeck-Loebenstein B. Impaired Immune Response to Primary but Not to Booster Vaccination Against Hepatitis B in Older Adults. Front Immunol. 2018 May 15;9:1035. doi: 10.3389/fimmu.2018.01035. eCollection 2018.
  39. Weinberger B. Vaccines for the elderly: current use and future challenges. Immun Ageing. 2018 Jan 22;15:3. doi: 10.1186/s12979-017-0107-2. eCollection 2018.
  40. Zhu B, Dockrell HM, Ottenhoff THM, Evans TG, Zhang Y. Tuberculosis vaccines: Opportunities and challenges. Respirology. 2018 Apr;23(4):359-368. doi: 10.1111/resp.13245. Epub 2018 Jan 17.

Publications 2017

  1. Barton A.J., Hill J., Andrew P., Blohmke C., Transcriptomics in Human Challenge Models. Front Immunol. 2017; 18;8:1839. doi: 10.3389/fimmu.2017.01839
  2. Beigier-Bompadre M., Montagna G.N. , Kühl A.A. , Lozza L. , Weiner J., Kupz A., Vogelzang A., Mollenkopf H-J, Löwe D., Bandermann S., Dorhoi A., Brinkmann V., Matuschewski K., Kaufmann S.H.E. Mycobacterium tuberculosis infection modulates adipose tissue biology. PLoS Pathog. (2017) doi: 10.1371/journal.ppat.1006676.
  3. Billeskov R., Lindenstrøm T., Woodworth J., Vilaplana C., Cardona P., Cassidy J.P., Mortensen R., Agger E.M., Andersen P., High antigen dose is detrimental to post exposure vaccine protection against tuberculosis. Front. Immunol. (2017). doi: 10.3389/fimmu.2017.01973.
  4. Christensen D., Christensen J.P., Korsholm K.S., Isling L.K., Erneholm K.S., Thomsen A.R., Anderson P., Seasonal influenza split vaccines confer partial cross-protection against heterologous influenza virus in ferrets when combined with the CAF01 adjuvant. Front. Immunol. (2017). doi: 10.3389/fimmu.2017.01928.
  5. De Groot A.M., Platteel A.C.M., Kuijt N., van Kooten P., Jan Vos P.J., Sijts A.J.A.M., van der Maaden K., Nanoporous Microneedle Arrays Effectively Induce Antibody Responses against Diphtheria and Tetanus Toxoid. Front. Immunol. (2017) doi: 10.3389/fimmu.2017.01789
  6. Domaszewska T., Scheuermann L. , Hahnke K. , Mollenkopf H. , Dorhoi A. , Kaufmann S. H. E. , Weiner J., Concordant and discordant gene expression patterns in mouse strains identify best-fit animal model for human tuberculosis. Sci Rep. (2017) doi: 10.1038/s41598-017-11812-x.
  7. Gengenbacher M, Nieuwenhuizen NE, Kaufmann S. BCG – old workhorse, new skills. Curr Opin Immunol. (2017) Jul doi: 10.1016/j.coi.2017.06.007.
  8. Gjøen JE, Jenum S, Sivakumaran D, Mukherjee A, Macaden R, Kabra SK, Lodha R,Ottenhoff THM, Haks MC, Doherty TM, Ritz C, Grewal HMS. Novel transcriptional signatures for sputum-independent diagnostics of tuberculosis in children. Sci Rep. (2017) Jul DOI: 10.1038/s41598-017-05057-x.
  9. Gould VMW, Francis JN, Anderson KJ, Georges B, Cope AV, Tregoning JS. Nasal IgA Provides Protection against Human Influenza Challenge in Volunteers with Low Serum Influenza Antibody Titre. Front Microbiol. (2017) May DOI: 10.3389/fmicb.2017.00900.
  10. Gutjahr A, Papagno L, Nicoli F, Lamoureux A, Vernejoul F, Lioux T, Gostick E, Price DA, Tiraby G, Perouzel E, Appay V, Verrier B, Paul S. Cutting Edge: A Dual TLR2 and TLR7 Ligand Induces Highly Potent Humoral and Cell-Mediated Immune Responses. J Immunol. (2017) Jun DOI: 10.4049/jimmunol.1602131.
  11. Haks M. H., Bottazzi B., Cecchinato V, De Gregorio, Del Giudice G, Kaufmann SHE, Lanzavecchia A, Lewis DJM, Maertzdorff J, Mantovani A, Sallusto F, Sironi M, Uguccioni M, Ottenhoff T.H.M. Molecular signatures of immunity and immunogenicity in infection and vaccination. Front Immunol. (2017) doi: 10.3389/fimmu.2017.01563.
  12. Jin C., Gibani M.M., Moore M., Juel H.B., Jones E., Meiring ., Harris V., Gardner J., Nebykova A., Kerridge S.A., Hill J., Thomaides-Brears H., Blohmke C.J., Yu L.M., Angus B., Pollard A.J., Efficacy and immunogenicity of a Vi-tetanus toxoid conjugate vaccine in the prevention of typhoid fever using a controlled human infection model of Salmonella Typhi: a randomised controlled, phase 2b trial. Lancet (2017) DOI:dx.doi.org/10.1016/ S0140-6736(17)32149-9
  13. Kratochvil S., Mckay P.F., Chung A.W., Kent S., Gilmore J., Shattock R.J., Immunoglobulin G1 Allotype Influences Antibody Subclass Distribution in Response to HIV gp140 Vaccination. Front. Immunol. (2017) doi: 10.3389/fimmu.2017.01883
  14. Kaufmann S., Weiner J., Maertzdorf J., Accelerating tuberculosis vaccine trials with diagnostic and prognostic biomarkers. Expert Rev Vaccines. (2017) DOI: 10.1080/14760584.2017.1341316
  15. Launay O., Lewis D.J.M., Anemona A., Loulergue P., Leahy J., Sciré A.S., Maugard A., Marchetti E, Zancan S, Huo Z, Rondini S, Marhaba R, Finco O, Martin LB, Auerbach J, Cohen D, Saul A, Gerke C, Podda A. Safety Profile and Immunologic Responses of a Novel Vaccine Against Shigella sonnei Administered Intramuscularly, Intradermally and Intranasally: Results From Two Parallel Randomized Phase 1 Clinical Studies in Healthy Adult Volunteers in Europe. EBioMedicine. (2017) DOI: 10.1016/j.ebiom.2017.07.013
  16. Lindenstrøm T., Albanus Moguche A., Damborg M., Agger E.M., Urdahl K., Andersen P., T Cells Primed by Live Mycobacteria Versus a Tuberculosis Subunit Vaccine Exhibit Distinct Functional Properties. E EBioMedicine (2017) DOI: dx.doi.org/10.1016/j.ebiom.2017.12.004
  17. Loxton A.G., Knaul J.K., Grode L., Gutschmidt A., Meller C., Eisele B., Johnstone H, van der Spuy G., Maertzdorf J., Kaufmann S.H., Hesseling A.C., Walzl G., Cotton M.F., VPM Study Group. Safety and Immunogenicity of the Recombinant Mycobacterium bovis BCG Vaccine VPM1002 in HIV-Unexposed Newborn Infants in South Africa. Clin Vaccine Immunol. (2017) DOI: 10.1128/CVI.00439-16.
  18. Majlessi L., Sayes F., Bureau J.F., Pawlik A., Michel V., Jouvion V., Huerre M., Severgnini M., Consolandi C., Peano C., Brosch R., Touati E., Leclerc C. Colonization with Helicobacter is comcomitant with modified gut microbiota and drastic failure of the immune control of Mycobacterium tuberculosis. Mucosal Immunology. (2017); doi: 10.1038/mi.2016.14
  19. Mourik B.C., Lubberts E., de Steenwinkel J.E.M., Ottenhoff T.H.M., Leenen P.J.M. Interactions between Type 1 Interferons and the Th17 Response in Tuberculosis: Lessons Learned from Autoimmune Diseases. Front Immunol. (2017) Apr DOI: 10.3389/fimmu.2017.00294.
  20. Nieuwenhuizen N.E. , Kulkarni P. S., Shaligram U., Cotton MF , Rentsch C.A., Eisele B. , Grode L., Kaufmann S.H.E. The Recombinant Bacille Calmette–Guérin Vaccine VPM1002: Ready for Clinical Efficacy Testing. Front Immunol.(2017) doi: 10.3389/fimmu.2017.01147
  21. Obiero C.W., Ndiaye A.G.W., Scirè A.S., Kaunyangi B.M., Marchetti E., Gone A.M., Schutte L.D., Riccucci D., Auerbach J., Saul A., Martin L.B., Bejon P., Njuguna P., Podda A., A phase 2 randomized study to evaluate the safety and immunogenicity of the 1790GAHB GMMA vaccine against Shigella sonnei administered intramuscularly to adults from a shigellosis-endemic country. Front. Immunol. (2017).
  22. Olafsdottir T.A., Alexandersson K.F., Sveinbjornsson G., Lapini G., Palladino L., Montomoli E., Del Giudice G., Gudbjartsson D.F., Jonsdottir I., Age and influenza specific pre-vaccination antibodies strongly affect influenza vaccine responses in the Icelandic population whereas disease and medication have small effects. Front. Immunol. (2017).
  23. Olsen A.W., Lorenzen E.K., Rosenkrands I., Follmann F., Andersen., Protective effect of vaccine promoted neutralizing antibodies against the intracellular pathogen Chlamydia trachomatis. Front. Immunol. (2017) doi: 10.3389/fimmu.2017.01652.
  24. Ottenhoff T.H.M., Haks M.C., Bottazzi B., Cecchinato V., De Gregorio C., Del Giudice G., Kaufmann S.H.E., Lanzavecchia A., Lewis D.J.M., Maertzdorff J., Mantovani A., Sallusto F., Sironi , Molecular signatures of immunity and immunogenicity in infections and vaccination, Front. Immunol. (2017) doi: 10.3389/fimmu.2017.01563
  25. Pangrazzi L, Meryk A, Naismith E, Koziel R, Lair J, Krismer M, Trieb K, Grubeck-Loebenstien B. “Inflamm-aging” influences immune cell survival factors in human bone marrow. European Journal of Immunolog. (2017) doi: 10.1002/eji.201646570
  26. Pangrazzi L, Naismith E, Meryk A, Keller M, Jenewein B, Trieb K, Grubeck-Loebenstein B. Increased IL-15 Production and Accumulation of Highly Differentiated CD8+ Effector/Memory T Cells in the Bone Marrow of Persons with Cytomegalovirus. Front Immunol. 2017; 19;8:715. doi: 10.3389/fimmu.2017.00715
  27. Pei G., The E3 ubiquitin ligase NEDD4 enhances killing of membrane-perturbing intracellular bacteria by promoting autophagy. Autophagy (2017), Autophagy. (2017) doi: 10.1080/15548627.2017.137616
  28. Platteel A.C.M, Henri S., Zaiss D.M., Sijts A.J.A.M. Dissecting antigen processing and presentation routes in dermal vaccination strategies. Vaccine (2017) doi: 10.1016/j.vaccine.2017.10.044
  29. Platteel A., Nieuwenhuizen N.E., Domaszewska T., Schuerer S., Zedler U., Brinkmann V., Sijts A., Kaufmann S.H.E., Efficacy testing of H56 cDNA tattoo immunization against tuberculosis in a mouse model. Front. Immunol. (2017) doi: 10.3389/fimmu.2017.01744.
  30. Platteel A., Liepe J., Van Eden W., Mishto M., Sijts A.J.A.M., An unexpected major role for proteosome-catalyzed peptide splicing in generation of T cell epitopes: is there relevance for vaccine development? Front. Immunol. (2017) doi: 10.3389/fimmu.2017.01441
  31. Platteel A.C.M., Liepe J., Textoris-Taube K., Keller C., Henklein P., Schalkwijk H.H., Cardoso R., Kloetzel P.M., Mishto M., Sijts A.J.A.M.. Multi-level Strategy for Identifying Proteasome-Catalyzed Spliced Epitopes Targeted by CD8+ T Cells during Bacterial Infection. Cell Rep. (2017) Aug DOI: 10.1016/j.celrep.2017.07.026.
  32. Rességuier J., Delaune E., Coolen A.L., Levraud J.P., Boudinot P., Le Guellec D., Verrier B., Specific and Efficient Uptake of Surfactant Free Poly (Lactic Acid) Nanovaccine Vehicles by Mucosal Dendritic Cells in Adult Zebrafish after Bath Immersion. Front Immunol. (2017) Feb DOI: 10.3389/fimmu.2017.00190.
  33. Richard M, Herfst S, van den Brand JMA, de Meulder D, Lexmond P, Bestebroer TM, Fouchier RAM. Mutations Driving Airborne Transmission of A/H5N1 Virus in Mammals Cause Substantial Attenuation in Chickens only when combined. Sci Rep. (2017). doi: 10.1038/s41598-017-07000-6.
  34. Rubino M., Kunderfranco P., Basso G., Greco C.M., Pasqualini F., Serio S., Roncalli M., Laghi L., Mantovani A., Papait R., Garlanda C., Epigenetic regulation of the extrinsic oncosuppressor PTX3 gene in inflammation and cancer. Oncoimmunology. (2017) May DOI: 10.1080/2162402X.2017.1333215.
  35. Schmidt S.T., Neustrup MA, Harloff-Helleberg S., Korsholm K.S., Rades T., Andersen P., Christensen D., Foged C. Systematic Investigation of the Role of Surfactant Composition and Choice of oil: Design of a Nanoemulsion-Based Adjuvant Inducing Concomitant Humoral and CD4+ T-Cell Responses. Pharm Res. (2017). doi: 10.1007/s11095-017-2180-9
  36. Tornack J., Reece S., Bauer W., Vogelzang A., Bandermann S., Zedler U., Sting G., Kaufmann S., Melchers F., Human and Mouse Hematopoietic Stem Cells Are a Depot for Dormant Mycobacterium tuberculosis. Plos One (2017) doi: 10.1371/journal.pone.0169119
  37. Weinberger B., Keller M., Grubeck-Loebenstein B., Long-term maintenance of diphtheria-specific antibodies after booster vaccination is hampered by latent infection with Cytomegalovirus. Immun Ageing.(2017) Jun DOI: 10.1186/s12979-017-0099-y
  38. Weinberger B., Bueno V., Lord J., Jackson T., Effects of ageing on the vaccination response. The Ageing Immune System and Health. (2017) ISBN 978-3-319-43365-3.
  39. Weiner J., Kaufmann S.H.E. High-throughput and computational approaches for diagnostic and prognostic host tuberculosis biomarkers. Int J Infect Dis. (2017) doi: 10.1016/j.ijid.2016.10.017.
  40. Wern JE, Sorensen MR, Olsen AW, Andersen P, Follmann F. Simultaneous Subcutaneous and Intranasal Administration of a CAF01-Adjuvanted Chlamydia Vaccine Elicits Elevated IgA and Protective Th1/Th17 Responses in the Genital Tract. Front Immunol. (2017) doi: 10.3389/fimmu.2017.00569.
  41. Wilkins A.L., Kazmin D., Napolitani G., Clutterbuck E.A., Pulendran B., Siegrist C.A., Andrew J. Pollard. AS03 and MF59 adjuvanted influenza vaccines in children. Front. Immunol. (2017) doi: 10.3389/fimmu.2017.01760
  42. Woodworth J.S. , Cohen S.B. , Moguche A.O. , Plumlee C.R. , Agger E.M. , Urdahl K.B. , Andersen P. Subunit vaccine H56/CAF01 induces a population of circulating CD4 T cells that traffic into the Mycobacterium tuberculosis-infected lung. Mucosal Immunol. (2017) doi: 10.1038/mi.2016.70.
  43. Zhivaki D, Lemoine S, Lim A, Morva A, Vidalain PO, Schandene L, Casartelli N, Rameix-Welti MA, Hervé PL, Dériaud E, Beitz B, Ripaux-Lefevre M, Miatello J, Lemercier B, Lorin V, Descamps D, Fix J, Eléouët JF, Riffault S, Schwartz O, Porcheray F, Mascart F, Mouquet H, Zhang X, Tissières P, Lo-Man R. Respiratory Syncytial Virus Infects Regulatory B Cells in Human Neonates via Chemokine Receptor CX3CR1 and Promotes Lung Disease Severity. Immunity. (2017) DOI: 10.1016/j.immuni.2017.01.010.

Publications 2016

  1. Anselmo A, Riva F, Gentile S, Soldani et al. Expression and function of IL-1R8 (TIR8/SIGIRR): a regulatory member of the IL-1 receptor family in platelets. Cardiovascular Research. (2016);111(4):373-84. doi: 10.1093/cvr/cvw162
  2. Badamchi-Zadeh A, McKay PF, Korber BT, et al. A Multi-component prime-Boost vaccination regimen with a consensus MOMP antigen enhances Chlamydia trachomatis clearance. Frontiers in Immunology (2016); 7: doi.org/10.3389/fimmu.2016.00162
  3. Barocchi M A., Black S., Rappuoli R. Multicriteria decision analysis and core values for enhancing vaccine-related decision-making. Science Translational Medicine (2016) June doi: 10.1126/scitranslmed.aaf0756
  4. Billeskov R, Tan EV, Cang M, Abalos RM, Burgos J, Pedersen BV, Christensen D, Agger EM, Andersen P. Testing the H56 vaccine delivered in 4 different adjuvants as a BCG-Booster in a non-human primate model of Tuberculosis. PLoS One. (2016) Aug; 11(8) doi: 10.1371/journal.pone.0161217.
  5. Boer, MC; van Meijgaarden, KE; Goletti, D; Vanini, V; Prins, C; Ottenhoff, THM; Joosten, SA. KLRG1 and PD-1 expression are increased on T-cells following tuberculosis-treatment and identify cells with different proliferative capacities in BCG-vaccinated adults. Tuberculosis (2016) doi: 10.1016/j.tube.2015.11.008
  6. Bonacina F, Barbieri SS, Cutuli L, Amadio P, Doni A, Sironi M, Tartari S, Mantovani A, Bottazzi B, Garlanda C, Tremoli E, Catapano AL, Norata GD. Vascular pentraxin 3 controls arterial thrombosis by targeting collagen and fibrinogen induced platelets aggregation. Biochim Biophys Acta. Molecular and Cell Biology of Lipids (2016), 1862:1182-90. doi: 10.1016/j.bbadis.2016.03.007.
  7. Bottazzi B, Inforzato A, Messa M, Barbagallo M, Magrini E, Garlanda C, Mantovani A. The pentraxins PTX3 and SAP in innate immunity, regulation of inflammation and tissue remodelling. Journal of Hepatology. (2016), 64:1416-1427. doi: 10.1016/j.jhep.2016.02.029.
  8. Cecchinato V, Bernasconi E, Speck R, Proietti M, Sauermann U, D’Agostino G, denelon G, Rezzonico Jost T, Grassi F, Raeli L, Schoeni-Affolter F, Stahl-Hennig C, Uguccioni M. Impairment of CCR6+ and CXCR3+ Th Cell migration in HIV-1 infection is rescued by modulating actin polymerization. Journal of Immunology (2016) doi: 10.4049/jimmunol.16005688
  9. Ciabattini A., Pettini E., Fiorino F., Pastore G.1, Andersen P., Pozzi G, and Medaglini D. Modulation of primary immune response by different vaccine adjuvants. Frontiers in Immunology., (2016) doi.org/10.3389/fimmu.2016.00427
  10. Christensen D, Mortensen R, Rosenkrands I, Dietrich J, Andersen P. Vaccine-induced TH17 cells are established as resident memory cells in the lung and promote local IgA responses. Mucosal Immnology. (2016); doi: 10.1038/mi.2016.28
  11. Chorny A, Casas-Recasens S, Sintes J, Shan M, Polentarutti N, García-Escudero R, Walland AC, Yeiser JR, Cassis L, Carrillo J, Puga I, Cunha C, Bastos H, Rodrigues F, Lacerda JF, Morais A, Dieguez-Gonzalez R, Heeger PS, Salvatori G, Carvalho A, Garcia-Sastre A, Blander JM, Mantovani A, Garlanda C, Cerutti A. The soluble pattern recognition receptor PTX3 links humoral innate and adaptive immune responses by helping marginal zone B cells. J Exp Med. (2016) Sep DOI: 10.1084/jem.20150282.
  12. Daigo K, Inforzato A, Barajon I, Garlanda C, Bottazzi B, Meri S, Mantovani A. Pentraxins in the activation and regulation of innate immunity. Immunol Rev. (2016) Nov DOI: 10.1111/imr.12476.
  13. Dalzon B, Lebas C, Jimenez G, Gutjahr A, Terrat C, Exposito JY, Verrier B, Lethias C. Poly(Lactic Acid) Nanoparticles Targeting α5β1 Integrin as Vaccine Delivery Vehicle, a Prospective Study. PLoS One. (2016) Dec DOI: 10.1371/journal.pone.0167663
  14. Dey A, Molodecky NA, Verma H, Sharma P, Yang JS, Saletti G, Ahmad M, Bahl SK, Wierzba TF, Nandy RK, Deshpande JM, Sutter RW, Czerkinsky C. Human circulating antibody-producing B cell as a predictive measure of mucosal immunity to Poliovirus. PLoS One. (2016) 11(1):e0146010; doi: 10.1371/journal.pone.0146010.
  15. Dorhoi A, Kaufmann SH. Pathology and immune reactivity: understanding multidimensionality in pulmonary Tuberculosis. Seminars in Immunopathology. (2016) (2):153-66. doi: 10.1007/s00281-015-0531-3.
  16. García-Sastre A. Proc. Systems vaccinology informs influenza vaccine immunogenicity. Proceedings of the National Academy of Sciences U S A. PNAS (2016); 113(7):1689-91; doi:10.1073/pnas.1525361113.
  17. Gengenbacher M., Nieuwenhuizen N., Vogelzang A., Liu H., Kaiser P., Schuerer S., Lazar D., Wagner I., Mollenkopf H., Kaufmann S. Deletion of nuoG from the vaccine candidate Mycobacterium bovis BCG _ureC::hly improves protection against Tuberculosis. American Society for Microbiology (2016) May doi: 10.1128/mBio.00679-1624
  18. Grasse M, Meryk A, Schirmer M, Grubeck-Loebenstein B, Weinberger B. Booster vaccination against tetanus and diphtheria: insufficient protection against diphtheria in young and elderly adults Immunity and Ageing. (2016);13(1):26. doi: 10.1186/s12979-016-0081-0
  19. Gutjahr A, Tiraby G, Perouzel E, Verrier B, Paul S. Triggering intracellular receptors for vaccine adjuvantation. Trends in Immunology. (2016);37(9):573-87. doi: 10.1016/j.it.2016.07.001.
  20. Huber A, Kallerup RS, Korsholm KS, Franzyk H, Lepenies B, Christensen D, Foged C, Lang R. Trehalose diester glycolipids are superior to the monoesters in binding to Mincle, activation of macrophages in vitro and adjuvant activity in vivo. Innate Immunology. (2016) (6):405-18. doi: 10.1177/1753425916651132. Epub 2016 Jun 1
  21. Jaillon S, Ponzetta A, Magrini E, Barajon I, Barbagallo M, Garlanda C, Mantovani A. Fluid phase recognition molecules in neutrophil-dependent immune responses. Seminars in Immunology. (2016), 28:109-118. doi: 10.1016/j.smim.2016.03.005.
  22. Jenum, S; Bakken, R; Dhanasekaran, S; Mukherjee, A; Lodha, R; Singh, S; Singh, V; Haks, MC; Ottenhoff, THM; Kabra, SK; Doherty, TM; Ritz, C; Grewal, HMS. BLR1 and FCGR1A transcripts in peripheral blood associate with the extent of intrathoracic tuberculosis in children and predict treatment outcome. Scientific Reports (2016)
  23. Joosten S., van Meijgaarden K., del Nonno F., Baiocchini A., Petrone L., Vanini V., Smits H., Palmieri F., Goletti D., Ottenhoff T HM. Patients with Tuberculosis have a dysfunctional circulating B-cell compartment, which normalizes following successful treatment. Plos Pathogens, (2016), doi: 10.1371/journal.ppat. 1005687
  24. Jukes JP et al. Non-glycosidic compounds can stimulate both human and mouse iNKT cells. European Journal of Immunology, (2016) doi: 10.1002/eji.2015461144
  25. Kaufmann, SHE. EFIS lecture. Immune response to tuberculosis: How to control the most successful pathogen on earth. Immunology letters (2016) doi: 10.1016/j.imlet.2016.05.006
  26. Kaufmann S., Fortune S., Pepponi I., Ruhwald M., Schrager L., Ottenhoff. T., TB Biomarkers, TB correlates and human challenge models: New tools for improving assessment of new TB vaccines. Tuberculosis (2016)
  27. Kaufmann SH, Dorhoi A. Molecular determinants in Phagocyte-Bacteria interactions. Immunity (2016);44(3):476-91; doi: 10.1016/j.immuni.2016.02.014
  28. Kaufmann S, Weiner J, Reyn CF., Novel approaches to TB vaccine development, International Journal of Infectious Diseases (2016) dx.doi.org/101016/j.ijid.2016.10.018
  29. Knudsen N, Olsen A, Buonsanti C, Follmann F, Zhang Y, Coler R, Fox C, Meinke A, D´Oro U, Casini D, Bonci A, Billeskov R, De Gregorio E, Rappuoli R, Harandi A, Andersen P & Agger E. Different human vaccine adjuvants promote distinct antigen-independent immunological signatures tailored to different pathogens. Nature Scientific Reports (2016); doi:10.1038/srep19570
  30. Kupz A-, Zedler U., Staber M., Kaufmann S., A mouse model of latent Tuberculosis infection to study intervention strategies to prevent reactiviaton. Plos one. (2016) doi: 10.1371/journal.pone.0155348
  31. Kupz A, Zedler U, Staber M, Perdomo C, Brosch R, Kaufmann S. ESAT-6-dependant cytosolic pattern recongnition drives noncognate tuberculosis control in vitro. The Journal of Clinical Investigation. (2016) April; doi: 10.1172/JC184978
  32. Lambert L., Ekaterina K., McDonald J., Grødeland G., Bogen B., Stubsrud E., Lindeberg M., Brunsvik Fredriksen A., Tregoning J. Section immunotherapies and vaccines article type: original research Title: DNA vaccines encoding antigen targeted to MHC class II induce influenza specific CD8+ T cell responses, enabling faster resolution of influenza disease. Frontiers in Immunology. (2016) Aug. doi.org/10.3389/fimmu.2016.00321
  33. Laubreton D, Bay S, Sedlik C, Artaud C, Ganneau C, Dériaud E, Viel S, Puaux AL, Amigorena S, Gérard C, Lo-Man R, Leclerc C. The fully synthetic MAG-Tn3 therapeutic vaccine containing the tetanus toxoid-derived TT830-844 universal epitope provides anti-tumor immunity. Cancer Immunology Immunotherapy. (2016) February, doi: 10.1007/s00262-016-1802-0. .
  34. Lebens, M; Terrinoni, M; Karlsson, SL; Larena, M; Gustafsson-Hedberg, T; Kallgard, S; Nygren, E; Holmgren, J. Construction and preclinical evaluation of mmCT, a novel mutant cholera toxin adjuvant that can be efficiently produced in genetically manipulated Vibrio cholera. Vaccine (2016) doi: 10.1016/j.vaccine.2016.03.002
  35. Legaz S, Exposito JY, Lethias C, Viginier B, Terzian C, Verrier B. Evaluation of polylactic acid nanoparticles safety using Drosophila model. Nanotoxicology. (2016) October (8): doi: 10.1080/17435390.2016.1181806
  36. Mohr E, Siegrist CA. Vaccine in early life – standing up to the challenges. Current Opinion in Immunology (2016) April; dx.doi.org 10./1016/j.coi.2016.04.004
  37. Muturi-Kioi V, Lewis D, Launay O, Leroux-Roels G, Anemona A, Loulergue P, Bodinham C, Aerssens A, Groth N, Saul A, Podda A. Neutropenia as an Adverse Event following Vaccination: Results from randomized clinical trials in healthy adults and systematic review. Plos One (2016) August doi: 10.1371/journal.pone.0157385
  38. Nakaya HI, Clutterbuck E, Kazmin D, Wang L, Cortese M, Bosinger SE, Patel NB, Zak DE, Aderem A, Dong T, Del Giudice G, Rappuoli R, Cerundolo V, Pollard AJ, Pulendran B, Siegrist CA. Systems biology of immunity to MF59-adjuvanted versus nonadjuvanted trivalent seasonal influenza vaccines in early childhood. Proceedings of the National Academy of Science U S A. (2016) Feb 113(7):1853-8.
  39. Olafsdottir T, Lindqvist M, Nookaew I, Andersen P, Maertzdorf J, Persson J, Christensen D, Zhang Y, Andersen J, Khoomrung S, Sen P, Agger E, Coler R, Carter D, Meinke A, Rappuoli R, Kaufmann S, Reed S, Harandi A. Comparative systems analyses reveal molecular signatures of clincally tested vaccine adjuvants. Nature Scientific Reports (2016) December. Doi: 10.1038/srep39097
  40. Pavot V, Climent N, Rochereau N, Garcia F, Genin C, Tiraby G, Vernejoul F, Perouzel E, Lioux T, Verrier B, Paul S. Directing vaccine immune responses to mucosa by nanosized particulate carriers encapsulating NOD ligands. Biomaterials. (2016) January doi: 10.1016/j.biomaterials.2015.10.034
  41. Perdomo C. Zedler U., kuhl A, Lozza L, Saikali P, Sander L, Vogelzang A, Kaufmann S, Kupz A. Mucosal BCG vaccination induces protective lung resident memory T cell populations against Tuberculosis. American Society for Microbiology (2016) doi: 10.1128/mBio.01686-16
  42. Pinti M, Appay V, Campisi J, Frasca D, Fülöp T, Sauce D, Larbi A, Weinberger B, Cossarizza A. Aging of the immune system – focus on inflammation and vaccination. European Journal of Immunology. (2016) Sep. doi: 10.1002/eji.201546178.
  43. Plateel, A.C.M., Mishto M., Textoris Taube, K., Keller, C., Liepe, J., Busch, D.H., Kloeztel, P.M., Sijts E.J.A.M., CD8+ T cells of Listeria monocytogenes-infected mice recognize both linear and spliced proteasome products. European Journal of Immunology, (2016) March; 46(5):1109-18. doi: 10.1002/eji.201545989
  44. Plateel, A.C.M., De Groot, A.M., Keller, C., Andersen, P., Ovaa, H., Kloetzel, P.M., Mishto, M., Sijts, E.J.A.M. 2016. Strategies to enhance immunogenicity of cDNA vaccine encoded antigens by modulation of antigen processing. Vaccine, (2016) Sep;34(42):5132-40. doi: 10.1016/j.vaccine.2016.08.03
  45. Anouk C. M. Platteel , Juliane Liepe , Willem van Eden , Michele Mishto , Alice J. A. M. Sijts. An Unexpected Major Role for Proteasome-Catalyzed Peptide Splicing in Generation of T Cell Epitopes: Is There Relevance for Vaccine Development? Frontiers in Immunology (2017) doi: 10.3389/fimmu.2017.01441
  46. Proudfoot A., and Uguccioni M. Modulation of chemokine responses: synergy and cooperativity. Frontiers in Immunology (2016) doi:dx.doi.org/10.3389/fimmu.2016.00183
  47. Rappuoli R, Bottomley MJ, D’Oro U, Finco O, De Gregorio E. Reverse vaccinology 2.0: Human immunology instructs vaccine antigen design. Journal of Experimental Medicine. (2016) April; 213(4):469-81. doi: 10.1084/jem.20151960.
  48. Russell RF, McDonald JU, Lambert L, Tregoning JS. Use of the microparticle NanoSiO2 as an adjuvant to boost vaccine immune responses in neonatal mice against influenza. The Journal of Virology (2016) April 90(9): 4735-44 doi: 10.1128/JVI.03159-15 ;
  49. Salabert, N; Todorova, B; Martinon, F; Boisgard, R; Zurawski, G; Zurawski, S; Dereuddre-Bosquet, N; Cosma, A; Kortulewski, T; Banchereau, J; Levy, Y; Le Grand, R; Chapon, C. Intradermal injection of an anti-Langerin-HIVGag fusion vaccine targets epidermal Langerhans cells in nonhuman primates and can be tracked in vivo. European Journal of Immunology (2016) doi: 10.1002/eji.201545465
  50. Schmidt, ST; Khadke, S; Korsholm, KS; Perrie, Y; Rades, T; Andersen, P; Foged, C; Christensen, D., The administration route is decisive for the ability of the vaccine adjuvant CAF09 to induce antigen-specific CD8(+) T-cell responses: The immunological consequences of the biodistribution profile. Journal of Controlled Release (2016) doi: 10.1016/j.jconrel.2016.08.034
  51. Sinha, A; Dey, A; Saletti, G; Samanta, P; Chakraborty, PS; Bhattacharya, MK; Ghosh, S; Ramamurthy, T, Kim, JO, Yang, JS; Kim, DW; Czerkinsky, C; Nandy, RK. Circulating Gut-Homing (alpha(4)beta(+)(7)) Plasmablast Responses against Shigella Surface Protein Antigens among Hospitalized Patients with Diarrhea. Clinical and Vaccine Immunology (2016) doi: 10.1128/CVI.00205-16
  52. Wang Y, Rahmen D, Mistry M, Lehner T. The effect of cellular stress on T and B cell memory pathways in immunised and unimmunised BALb/c mice Journal of Biomedical Chemistry (2016) August doi: 10.1074/jb.M116.746057
  53. Weinberger B. Adult vaccination against tetanus and diphtheria: The European perspective. Clinical and Experimental Immunology. (2016) June doi: 10.1111/cei.12822.
  54. Williams, EA; Lewis, DJM; Bertholet, S; Zazzi, M. Anticipating policy considerations for a future HIV vaccine: a preliminary study. Vaccine (2016) doi: 10.1016/j.vaccine.2016.03.086
  55. Woodworth J, Andersen P. Reprogramming the T Cell response to Tuberculosis. Trends in Immunology (2016) February; doi: dx.doi.org/10.1016/j.it.2015.12.009
  56. Wysocki AD., Latent Tuberculosis Infection Diagnostic and Treatment Cascade among Contacts in Primary Health Care in a City of Sao Paulo State, Brazil: Cross-Sectional Study. PLoS One (2016): doi: 10.1371/journal.pone.0155348
  57. Zak D, Penn-Nicolson A, Scriba TJ, Thompson E, Suliman S, Amon LM, Mahomed H, Erasmus M, Whatney W, Hussey GD, Abrahams D, Kafaar F, Hawkridge T, Verver S, Hughes EJ, Ota M, Sutherland J, Howe R, Dockrell HM, Boom WH, Thiel B, Ottenhoff TH, Mayanja-Kizza H, Crampin AC, Downing K, Hatherill M, Valvo J, Shankar S, Parida SK, Kaufmann SH, Walzl G, Aderem A, Hanekom WA; ACS and GC6-74 cohort study groups. A Blood RNA signature for tuberculosis disease risk; a prospective cohort study. The Lancet. (2016) March; doi.org/10.1016/S0140-6736(15)01316-1.
  58. Zimmerman N., Saiga H, Moura. Alves.P, Koehler A, Bandermann S, Dorhoi A, Kaufmann SH. Syndecans promote mycobacterial internalization by lung epithelial cells. Cell Microbiology (2016) June, doi:10.1111/cmi.12627
  59. Zimmermann, N; Thormann, V; Hu, B; Kohler, AB; Imai-Matsushima, A; Locht, C; Arnett, E; Schlesinger, LS; Zoller, T; Schurmann, M; Kaufmann, SHE; Wardemann, H, Human isotype-dependent inhibitory antibody responses against Mycobacterium tuberculosis. EMBO Molecular Medicine (2016) doi: 10.15252/emmm.201606330

Publications 2015

  1. Adam, L; Rosenbaum, P; Cosma, A; Le Grand, R; Martinon, F, Identification of skin immune cells in non-human primates. Journal of Immunogical Methods (2015) doi: 10.1016/j.jim.2015.07.010
  2. Agger EM. Novel adjuvant formulations for delivery of anti-tuberculosis vaccine candidates. Advanced Drug Delivery Reviews (2015) November. pii: S0169-409X(15)00276-8. doi: 10.1016/j.addr.2015.11.012.
  3. Andersen P, Urdahl KB. TB vaccines; promoting rapid and durable protection in the lung. Curr Opin Immunol. (2015) doi: 10.1016/j.coi.2015.06.001.
  4. Badamchi-Zadeh A, McKay P, Holland M, Paes W, Brzozowski A, Lacey C, Follmann F, Tregoning J, Shattock R. Intramuscular Immunisation with Chlamydial Proteins Induces Chlamydia trachomatis Specific Ocular Antibodies PloS One (2015) October doi.org/10.1371/journal.pone.0141209
  5. Becattini S, Latorre D, Mele F, Foglierini M, De Gregorio C, Cassotta A, Fernandez B, Kelderman S, Schumacher TN, Corti D, Lanzavecchia A, Sallusto F. T cell immunity. Functional heterogeneity of human memory CD4⁺ T cell clones primed by pathogens or vaccines. Science (2015) January; 347(6220):400-6. doi: 10.1126/science.1260668
  6. Boer, MC; Joosten, SA; Ottenhoff, THM, Regulatory T-cells at the interface between human host and pathogens in infectious diseases and vaccination. Frontiers in Immunology (2015) doi: 10.3389/fimmu.2015.00217
  7. Boianelli A, Pettini E, Prota G, Medaglini D, Vicino A. A Stochastic Model for CD4+ T Cell proliferation and dissemination network in primary Immune response. PLoS One (2015) August ;10(8):e0135787. doi: 10.1371/journal.pone.0135787.
  8. Bøje S, Olsen AW, Erneholm K, Agerholm J S, Jungersen G, Andersen P, Follmann F. A multi-subunit Chlamydia vaccine inducing neutralizing antibodies and strong IFN-g+ CMI responses protects against a genital infection in minipigs. Immunology and Cell Biology (2015) August; doi: 10.1038/icb.2015.79.
  9. Bonavita E,et al. PTX3 is an extrinsic oncosuppressor regulating complement-dependent inflammation in cancer. Cell. (2015) February;160(4):700-14. doi: 10.1016/j.cell.2015.01.004.
  10. Boon M., et al. Short-term high-fat diet increases macrophage markers in skeletal muscle accompanied by impaired insulin signaling in healthy male subjects. Clinical Science (Lond) (2015) January;128(2):143-51. doi: 10.1042/CS20140179. 167. Bottazzi B, et al. Recognition of Neisseria meningitidis by the long pentraxin PTX3 and its role as an endogenous adjuvant. PLoSOne (2015) March; 10(3):e0120807.doi: 0.1371/journal.pone.0120807.
  11. van Meijgaarden K.E., et al. Human CD8+ T-cells Recognizing Peptides from Mycobacterium tuberculosis (Mtb) Presented by HLA-E Have an Unorthodox Th2-like, multifunctional, Mtb Inhibitory Phenotype and Represent a Novel Human T-cell Subset. PLoS Pathog. (2015) doi: 10.1371/journal.ppat.1004671
  12. Cecchinato V, D’Agostino G, Raeli L, Uguccioni M. Chemokine interaction with synergy-inducing molecules: fine tuning modulation of cell trafficking. J Leukocyte Biology. (2015) December pii: jlb.1MR1015-457R.
  13. Ciabattini A, Prota G, Christensen D, Andersen P, Pozzi G, Medaglini D. Characterization of the antigen-specific CD4+ T cell response induced by prime-boost strategies with CAF01 and CpG adjuvants administered by the Intranasal and Subcutaneous Routes. Frontiers of Immunology. (2015) August; 6:430. doi: 10.3389/fimmu.2015.00430.
  14. Cliff JM, Kaufmann SH, McShane H, van Helden P, O’Garra A. The human immune response to tuberculosis and its treatment: a view from the blood. Immunological Reviews. (2015) March; 4(1):88-102. doi: 10.1111/imr.12269.
  15. Coppola M, van den Eeden SJF, Wilson L, Franken KLMC, Ottenhoff THM, Geluk A. Synthetic Long Peptide Derived from Mycobacterium tuberculosis Latency Antigen Rv1733c Protects against Tuberculosis, Clinical and Vaccine Immunology (2015) doi: 10.1128/CVI.00271-15
  16. Dolen Y et al. Co-delivery of PLGA encapsulated invariant NKT cell agonist with antigenic protein induce strong T cell-mediated antitumor immune responses. OncoImmunology. (2015) August:5(1):e1068493 doi: 10.1080/2162402X.2015.10684933
  17. Doni A, Musso T, Morone D, Bastone A, Zambelli V, Sironi M, Castagnoli C, Cambieri I, Stravalaci M, Pasqualini F, Laface I, Valentino S, Tartari S, Ponzetta A, Maina V, Barbieri SS,Tremoli E, Catapano AL, Norata GD, Bottazzi B, Garlanda C, Mantovani A. An acidic microenvironment sets the humoral pattern recognition molecule PTX3 in a tissue repair mode. Journal of Experimental Medicine. (2015); 212(6):905-25. doi: 10.1084/jem.20141268
  18. Elliott T.O.J.P., Olumuyiwa Owolabi, Donkor S., Kampmann B., Hill P, Ottenhoff T, Haks M., Kaufmann S., Maertzdorf J and Sutherland J., Dysregulation of apoptosis Is a risk factor for Tuberculosis disease progression. Journal of Infectious Diseases. (2015); DOI:10.1093/infdis/jiv238.
  19. Esterhuyse M., Weiner J., Caron E., Loxton A., Iannaccone M., Wagman C., Saikali P., Stanley K., Wolski W., Mollenkopf H., Schick M., Aebersold R., Linhart H., Walzl G., Kaufmann S.. Epigenetics and proteomics join transcriptomics in the quest for Tuberculosis biomarkers. American Society for Micorbiology mBio (2015); vol. 6 no. 5 e01187-15. doi: 10.1128/mBio.01187-15
  20. Garlanda C, Jaillon S, Doni A, Bottazzi B, Mantovani A. PTX3, a humoral pattern recognition molecule at the interface between microbe and matrix recognition. Current Opinion in Immunology. (2015) 38:39-44. doi: 10.1016/j.coi.2015.11.002. PubMed PMID: 26650391.
  21. Gavillet M B, Eberhardt CS,Auderset F, Castellino F ,Seubert A, Tregoning JS, Lambert PH, de Gregorio E, Del Giudice G, Siegrist CA. MF59 mediates its B cell adjuvanticity by promoting T follicular helper cells and thus germinal center responses in adult and early life. Journal of Immunology. (2015) May; 194(10):4836-45. doi: 10.4049/jimmunol.1402071.
  22. Haks MC, Goeman JJ, Magis-Escurra C and Ottenhoff THM. Focused human gene expression profiling using dual-color reverse transcriptase multiplex ligation-dependent probe amplification (dcRT-MLPA). Vaccine (2015); pii:S0264-410X(15)00518-6.doi: 0.1016/j.vaccine.2015.04.054.
  23. Hjelm A, et al. Autotransporter-based antigen display in bacterial ghosts. Applied and Environmental Microbiology. (2015). doi: 10.1128/AEM.02733-14.
  24. Hoang T, et al. Protein Energy Malnutrition during Vaccination Has Limited Influence on Vaccine Efficacy but Abolishes Immunity if Administered during Mycobacterium tuberculosis Infection. Infection and Immunity (2015) May; 83(5): 2118-26 doi: IAI.03030-14.
  25. Jiménez-Sánchez G, Pavot V, Chane-Haong C, Handké N, Terrat C, Gigmes D, Trimaille T, Verrier B. Preparation and in vitro evaluation of imiquimod loaded polylactide-based micelles as potential vaccine adjuvants. Pharmaceutical Research (2015); 32(1):311-20. doi: 10.1007/s11095-014-1465-5.
  26. Kallerup, RS; Madsen, CM; Schioth, ML; Franzyk, H; Rose, F; Christensen, D; Korsholm, KS; Foged, C Influence of trehalose 6,6 ‘-diester (TDX) chain length on the physicochemical and immunopotentiating properties of DDA/TDX liposomes. Eurpoean Journal of Pharmaceutics and Biopharmaceutics. (2015) Doi: 10.1016/j.ejpb.2014.10.015
  27. Kinnear E., Caproni LJ., Tregoning J.S. A Comparison of Red Fluorescent Proteins to Model DNA Vaccine Expression by Whole Animal In Vivo Imaging. Plos one (2015) doi: 10.1371/journal.pone.0130375
  28. Knezevic I, Moorthy V, Sheets R. WHO consultation on clinical evaluation of vaccines, 17-18 July 2014, WHO Headquarters, Geneva, Switzerland. Vaccine (2015); 33(17):1999-2003. doi: 10.1016/j.vaccine.2015.01.056.
  29. Lachmandas E. The effect of hyperglycaemia on in vitro cytokine production and macrophage infection with Mycobacterium tuberculosis. PLoS One (2015) doi:10.1371/journal.pone.0117941.
  30. Larena, M; Holmgren, J; Lebens, M; Terrinoni, M; Lundgren, A. Cholera Toxin, and the Related Nontoxic Adjuvants mmCT and dmLT, Promote Human Th17 Responses via Cyclic AMP-Protein Kinase A and Inflammasome-Dependent IL-1 Signaling. Journal of Immunology (2015) doi: 10.4049/jimmunol.1401633
  31. Legaz S, Exposito JY, Borel A, Candusso MP, Megy S, Montserret R, Lahaye V, Terzian C, Verrier B. A purified truncated form of yeast Gal4 expressed in Escherichia coli and used to functionalize poly(lactic acid) nanoparticle surface is transcriptionally active in cellulo. Protein Expression and Purification (2015) September; doi: 10.1016/j.pep.2015.05.009.
  32. Lemoine S, et al. Dectin-1 activation unlocks IL12A expression and reveals the TH1 potency of neonatal dendritic cells. J Allergy Clin Immunol. (2015); doi:10.1016/j.jaci.2015.02.030.
  33. Lorenzen E, Follmann F, Bøje S, Erneholm K, Olsen AW, Agerholm JS, Jungersen G, Andersen P. Intramuscular priming and intranasal boosting induce strong genital immunity through secretory IgA in minipigs infected with Chlamydia trachomatis. Frontiers of Immunology (2015) December; 6:628. doi: 10.3389/fimmu.2015.00628.
  34. Maertzdorf J et al. Molecular signatures for vaccine development. Vaccine (2015) April 6 doi: 10.1016/j.vaccine.2015.03.075.
  35. Olafsdottir T, Lindqvist M, Harandi AM. Molecular signatures of vaccine adjuvants. Vaccine (2015) doi: 10.1016/j.vaccine.2015.04.099.
  36. Olsen AW et al, Protection against Chlamydia trachomatis infection and upper genital tract pathological changes by vaccine-promoted neutralizing antibodies. Directed to the VD4 of the Major Outer Membrane Protein Journal of Infected Diseases. (2015); pii: jiv137.
  37. Pritz T, Lair J, Ban M, Keller M, Weinberger B, Krismer M, Grubeck-Loebenstein B. Plasma cell numbers decrease in bone marrow of old patients. European Journal of Immunology. (2015); 45(3):738-46. doi: 10.1002/eji.201444878.
  38. Prota G, Christensen D, Andersen P, Medaglini D., Ciabattini A., Peptide-specific T helper cells identified by MHC class II tetramers differentiate into several subtypes upon immunization with CAF01 adjuvanted H56 tuberculosis vaccine formulation. Vaccine (2015); doi:10.1016/j.vaccine.2015.09.024.
  39. Richard M, Herfst S, van den Brand JM, Lexmond P, Bestebroer TM, Rimmelzwaan GF, Koopmans M, Kuiken T, Fouchier RA. Low virulence and lack of airborne transmission of the Dutch highly pathogenic avian influenza virus H5N8 in ferrets. PLoS One. (2015); 10(6): e0129827. doi:10.1371/journal.pone.0129827.
  40. Ronacher K., Acquired immunodeficiencies and tuberculosis: focus on HIV/AIDS and diabetes mellitus. Immunological Reviews (2015) March; 2 64(1):121-37. doi: 10.1111/imr.12257.
  41. Russell RF, McDonald JU, Ivanova M, Zhong Z, Bukreyev A, Tregoning JS. The partial attenuation of Small Hydrophobic (SH) gene deleted RSV is associated with elevated IL-1β responses. Journal of Virology(2015); 89: 8974-81.2015 doi: 10.1128/JVI.01070-15.
  42. Saiga H, Nieuwenhuizen N, Gengenbacher M, Koehler AB, Schuerer S, Moura-Alves P, Wagner I, Mollenkopf HJ, Dorhoi A, Kaufmann SH. The Recombinant BCG ΔureC::hly Vaccine Targets the AIM2 Inflammasome to Induce Autophagy and Inflammation. J Infect Dis. 2015. doi: 10.1093/infdis/jiu675.
  43. Santone M1, Aprea S, Wu TY, Cooke MP, Mbow ML, Valiante NM, Rush JS, Dougan S, Avalos A, Ploegh H, De Gregorio E, Buonsanti C, D’Oro U. A new TLR2 agonist promotes cross-presentation by mouse and human antigen presenting cells. Human Vaccines and Immunotherapeutics (2015) August;11(8):2038-50. doi: 10.1080/21645515.2015.1027467.
  44. Sloot R, et al. Biomarkers can identify pulmonary tuberculosis in HIV-infected drug users months prior to clinical diagnosis. EbioMedicine (2015) ; doi: 10.1016/j.ebiom.2014.12.001.
  45. Tientcheu LD, Maertzdorf J, Weiner J, Adetifa IM, Mollenkopf HJ, Sutherland JS, Donkor S, Kampmann B, Kaufmann SH, Dockrell HM, Ota MO. Differential transcriptomic and metabolic profiles of M. africanum- and M. tuberculosis-infected patients after, but not before, drug treatment. Genes and Immunity. (2015); doi: 10.1038/gene.2015.21.
  46. Trimaille T, Verrier B. Micelle-based adjuvants for subunit vaccine delivery. Vaccines 2015 ;3(4):803-13. doi: 10.3390/vaccines3040803.
  47. Wang Y, Lavender P, Watson J, Arno M1,Lehner T. Stress activated DC induce dual IL-15 and IL1β mediated pathways, which may elicit CD4+ memory T cells and IFN stimulated genes. Journal of Biological Chemistry. (2015) ; doi:10.1074/jbc.M115.645754.
  48. Weinberger B, Joos C, Reed SG, Coler R, Grubeck-Loebenstein B., The stimulatory effect of the TLR4-mediated adjuvant glucopyranosyl lipid A is well preserved in old age. Biogerontology (2015) doi: doi: 10.1007/s10522-015-9576-x
  49. Weiner J, Kaufmann SH, Maertzdorf J. High-throughput data analysis and data integration for vaccine trials. Vaccine (2015);33(40):5249-55. doi: 10.1016/j.vaccine.2015.04.096.
  50. Wilson GJ, et al. The C-type lectin receptor CLECSF8/CLEC4Dis a keycomponent of anti-mycobacterial immunity. Cell Host & Microbe (2015); 17, 252–259 doi: 10.1016/j.chom.2015.01.004.
  51. Zak DE, Aderem A. Systems integration of innate and adaptive immunity. Vaccine (2015); 33 (40):5241-8. Doi:10.1016/j.vaccine.2015.05.098.

Publications 2014

  1. Andersen. P., S. H.E. Kaufmann. Novel vaccination strategies against tuberculosis. Cold Spring Harbour Perspectives in Medicine (2014); doi: 10.1101/cshperspect.a018523.
  2. Arnold CR, Pritz T, Brunner S, Knabb C ,Salvenmoser W, Holzwarth B, Thedieck K, Grubeck-Loebenstein B. T cell receptor-mediated activation is a potent inducer of macroautophagy in humanCD8(+)CD28(+) T cells but not in CD8(+)CD28(-) T cells. Exp Gerontol. 2014 Jun;54:75-83. doi: 10.1016/j.exger.2014.01.018. Epub 2014 Jan 24.
  3. Andersen P and Joshua S. Woodworth. Tuberculosis vaccines – rethinking the current paradigm. Trends in Immunology (2014); 35 (8) 387 – 395 doi: 10.1016/j.it.2014.04.006.
  4. Boer MC, van Meijgaarden KE, Joosten SA, Ottenhoff THM. CD8+ regulatory T Cells, and Not CD4+ T Cells, dominate suppressive phenotype and function after In vitro live mycobacterium bovis-BCG activation of human cells. PLoS One (2014); DOI:10.1371/journal.pone.0094192.
  5. Bottazzi, B. et al. Multiplexed label-free optical biosensor for medical diagnostics. Journal of Biomedical Optics (2014) January; 017006, doi:10.1117/1.JBO.19.1.017006.
  6. Canovi, M. et al. A new surface plasmon resonance-based immunoassay for rapid, reproducible and sensitive quantification of pentraxin-3 in human plasma. Sensors (Basel) (2014) June, 14 (6), 10864-75, doi: 10.3390/s140610864. 215. Cao RG, et al. Differences in antibody responses between trivalent inactivated influenza vaccine and live attenuated influenza vaccine correlate with the kinetics and magnitude of interferon signaling in children. Journal of Infectious Diseases (2014); 210(2):224-33. doi: 10.1093/infdis/jiu079.
  7. Capone S, et al. Fusion of HCV nonstructural antigen to MHC class II-associated invariant chain enhances T-cell responses induced by vectored vaccines in nonhuman primates. Molecular Therapy (2014); 22(5):1039-47. doi: 10.1038/mt.2014.15.
  8. Climent N, et al. Loading dendritic cells with PLA-p24 nanoparticles or MVA expressing HIV genes induces HIV-1-specific T cell responses. Vaccine (2014); 32(47):6266-76. doi: 10.1016/j.vaccine.2014.09.010.
  9. Commandeur, S et al. The in vivo expressed Mycobacterium tuberculosis (IVE-TB) antigen Rv2034 induces CD4+ T-cells that protect against pulmonary infection in HLA-DR transgenic mice. Vaccine (2014); 32(29):3580-8. doi: 10.1016/j.vaccine.2014.05.005.
  10. S Commandeur, et al. Clonal analysis of the T-cell response to in vivo expressed Mycobacterium tuberculosis protein Rv2034, using a CD154 expression based T-cell cloning method. PLoS One (2014) June; 9(6):e99203. doi: 10.1371/journal.pone.0099203.
  11. Cunha, C. et al. Genetic PTX3 deficiency and aspergillosis in stem-cell transplantation. New England Journal of Medicine (2014) January, 370: 421-432, doi:10.1056/NEJMoa1211161.
  12. Dadaglio G, et al and C. Leclerc. Antigen targeting to CD11b+ DCs in association with TLR4/TRIF signalling promotes strong CD8+ T cell responses. Journal of Immunology (2014) August; 193 (4), 1787-1798 doi: 10.4049/jimmunol.1302974.
  13. Daigo, K., Mantovani, A. & Bottazzi, B. The yin-yang of long pentraxin PTX3 in inflammation and immunity. Immunology letters (2014) September; 161(1):38-43 doi:10.1016/j.imlet.2014.04.012 2014.
  14. Daleke-Schermerhorn Mh, et al. Decoration of outer membrane vesicles with multiple antigens using an autotransporter approach. Applied and Environmental Microbiology (2014); 80(18):5854-65. doi: 10.1128/AEM.01941-14.
  15. De Gregorio E, Rappuoli R. From empiricism to rational design: a personal perspective of the evolution of vaccine development. Nature Reviews Immunology (2014) July; 14(7):505-14. doi:10.1038/nri3694.
  16. Dorhoi A, Iannaccone M, Maertzdorf J, Nouailles G, Weiner J 3rd, Kaufmann SH. Reverse Translation in Tuberculosis: Neutrophils provide clues for understanding development of active disease. Frontiers of Immunology (2014); 5:36; doi: 10.3389/fimmu.2014.00036.
  17. Duque-Correa, M.A., et al. Macrophage arginase-1 controls bacterial growth and pathology in hypoxic tuberculosis granulomas. Proceedings of the National Academy of Sciences USA PNAS (2014) September; 111(38):E4024-32. doi: 10.1073/pnas.1408839111. 227. Dutruel C et al Vaccine. TRANSVAC workshop on standardisation and harmonisation of analytical platforms for HIV, TB and malaria vaccines: ‘How can big data help?’; 31;32(35):4365-8. doi: 10.1016/j.vaccine.2014.06.014. 228. Epaulard O, Adam L, Poux C, Zurawski G, Salabert N, Rosenbaum P, Dereuddre-Bosquet N, Zurawski S, Flamar AL, Oh S, Romain G, Chapon C, Banchereau J, Lévy Y, Le Grand R, Martinon F. Macrophage- and neutrophil-derived TNF-α instructs skin langerhans cells to prime antiviral immune responses. Journal of Immunology (2014) doi: 10.4049/jimmunol.1303339 229. Finco O. and Rappuoli R. Designing vaccines for the twenty first century society. Frontiers of Immunology. (2014) January; 5: 12. doi: 10.3389/fimmu.2014.00012. 230. Geluk A, van Meijgaarden KE, Joosten SA, Commandeur S, Ottenhoff TH. Innovative strategies to identify M. tuberculosis antigens and epitopes using genome-wide analyses. Frontiers in Immunology (2014) January; 5:256. doi: 10.3389/fimmu.2014.00256. 231. Goeijenbier M., van Gorp E, Van den Brand J, Stittelaar K, Bakhtiari K, Roelofs J, van Amerongen G, Kuiken T, Martina B, Meijers J and Osterhaus A. Activation of coagulation and tissue fibrin deposition in experimental influenza in ferrets. BMC Microbiology (2014) doi: 10.1186/1471-2180-14-134 232. Hervas Stubbs S., Riezu-Boj JI, Mancheño U, Rueda P, Lopez L, Alignani D, Rodríguez-García E, Thieblemont N, Leclerc C. Conventional but not plasmacytoid dendritic cells foster the systemic virus-induced type I IFN response needed for efficient CD8 T cell priming. Journal of Immunology (2014) doi: 10.4049/jimmunol.1301440
  18. Jaillon S, et al. The long pentraxin PTX3 as a key component of humoral innate immunity and a candidate diagnostic for inflammatory diseases. International Archives of Allergy and Immunology. (2014) December; 165:165-78. doi: 10.1159/000368778.
  19. Jaillon, S. et al. The Humoral Pattern Recognition Molecule PTX3 Is a key component of innate immunity against urinary tract infection. Immunity (2014); 40, 621-632, doi:10.1016/j.immuni.2014.02.015 2014.
  20. Job, E. R. et al. A single amino acid substitution in the hemagglutinin of H3N2 subtype influenza A viruses is associated with resistance to the long pentraxin PTX3 and enhanced virulence in mice. Journal of Immunology (2014) January; 192 (1), 271-281, doi:10.4049/jimmunol.1301814.
  21. Jong W. et al. An autotransporter display platform for the development of multivalent recombinant bacterial vector vaccines. Microbial Cell Factories (2014) November ;13(1):162 doi:10.1186/s12934-014-0162-8.
  22. Kakeda M, Schlapbach C, Danelon G, Tang MM, Cecchinato V, Yawalkar N, Uguccioni M. Innate immune cells express IL-17A/F in acute generalized exanthematous pustulosis and generalized pustular psoriasis. Archives of Dermalogical Research (2014), 306:933-8. doi: 10.1007/s00403-014-1488-0
  23. Karlsen K, Korsholm KS, Mortensen R, Ghiasi SM, Andersen P, Foged C, Christensen D. A stable nanoparticulate DDA/MMG formulation acts synergistically with CpG ODN 1826 to enhance the CD4⁺ T-cell response. Nanomedicine (2014);9(17):2625-38. doi: 10.2217/nnm.14.197
  24. Kaufmann SH, Lange C, Rao M, Balaji KN, Lotze M, Schito M, Zumla AI, Maeurer M. Progress in tuberculosis vaccine development and host-directed therapies-a state of the art review. Lancet Respiratory Medicine. (2014); 2(4):301-320. doi: 10.1016/S2213-2600(14)70033-5
  25. Kaufmann SH, McElrath MJ, Lewis DJ, Del Giudice G. 2014. Challenges and responses in human vaccine development. Current Opinion in Immunology (2014) January; 28:18-26. doi: 10.1016/j.coi.2014.01.009.
  26. Kaufmann SH., Tuberculosis vaccine development at a divide. Current Opinion in Pulmonary Medicine (2014) May; 20(3):294-300. doi: 10.1097/MCP.0000000000000041.
  27. Kaufmann SH, Cotton MF, Eisele B, Gengenbacher M, Grode L, Hesseling AC, Walzl G. The BCG replacement vaccine VPM1002: from drawing board to clinical trial. Expert Review of Vaccines (2014) May; 13(5):619-30. doi: 10.1586/14760584.2014.905746.
  28. Knaul JK, Jörg S, Oberbeck-Mueller D, Heinemann E, Scheuermann L, Brinkmann V, Mollenkopf HJ, Yeremeev V, Kaufmann SH, Dorhoi A. Lung-residing myeloid-derived suppressors display dual functionality in murine pulmonary tuberculosis. Am J Respir Crit Care Med. (2014) Nov 1;190(9):1053-66. doi: 10.1164/rccm.201405-0828OC
  29. Knudsen NP, et al. Tuberculosis vaccine with high predicted population coverage and compatibility with modern diagnostics. Proceedings of the National Academy of Sciences USA PNAS (2014) January; 111(3):1096-101. doi: 10.1073/pnas.1314973111.
  30. Korsholm KS et al. Induction of CD8+ T-cell responses against subunit antigens by the novel cationic liposomal CAF09 adjuvant. Vaccine (2014); 32(31):3927-35.doi:10.1016/ j.vaccine.2014.05.050.
  31. Lewis DJM, Wang Y, Huo Z, Giemza R, Babaahmady K, Rahman D, Shattock RJ, Singh M and Lehner T. 2013. Effect of Vaginal Immunization with HIVgp140 and HSP70 on HIV-1 Replication and Innate and T Cell Adaptive Immunity in Women. Journal of Virology (2014) doi:10.1128/JVI.01621-14
  32. Maertzdorf, J., Kaufmann S., Weiner J., Toward a unified biosignature for tuberculosis. Cold Spring Harbour Perspectives in Medicine (2014); 5(1):a018531. doi: 10.1101/cshperspect.a018531.
  33. Michelini Z, Negri D, Biava M, Baroncelli S, Spada M, Leone P, Bona R, Blasi M, Nègre D, Klotman ME, Cara A. Murine granulocyte 1 macrophage colony stimulating factor expressed from a bicistronic SIV-based Integrase defective lentiviral vector does not enhance T-cell responses in mice. Viral Immunology (2014); 27(10):512-520, 2014. doi: 10.1089/vim.2014.0062.
  34. Mihret, A., et al. Combination of gene expression patterns in whole blood discriminate between tuberculosis infection states. BMC Infectious Disease (2014); 14:257. doi: 10.1186/1471-2334-14-257.
  35. Nouailles G, et al CXCL5-secreting pulmonary epithelial cells drive destructive neutrophilic inflammation in tuberculosis. The Journal of Clinical Investigaiton (2014); 124(3):1268-82. doi: 10.1172/JCI72030.
  36. Olsen AW, Andersen P, Follmann F. Characterization of protective immune responses promoted by human antigen targets in a urogenial Chlamydia trachomatis mouse model. Vaccine (2014) February; 32(6): 685-692, doi: 10.1016/j.vaccine.2013.11.100.
  37. Pappas L et al, Rapid development of broadly influenza neutralizing antibodies through redundant mutations. Nature (2014); 516(7531):418-22. doi: 10.1038/nature13764.
  38. Pavot V, Rochereau N, Lawrence P, Girard MP, Genin C, Verrier B, Paul S. Recent progress in HIV vaccines inducing mucosal immune responses. AIDS (2014); 28(12):1701-18 doi: 10.1097/QAD.0000000000000308.
  39. Pritz T., Weinberger B., Grubeck-Loebenstein B. The aging bone marrow and its impact on immune responses in old age. Immunology Letters (2014) doi: 10.1016/j.imlet.2014.06.016.
  40. Rappuoli R, Medaglini D. Big Science for Vaccine Development. Vaccine (2014) pii: S0264-410X(14)00872-X. doi: 10.1016/j Vaccine.2014.06.071.
  41. Rappuoli R, Pizza M, Del Giudice G, De Gregorio E. Vaccines, new opportunities for a new society. Proceedings of National Academy of Sciences U S A PNAS (2014); 111(34):12288-93. doi: 10.1073/pnas.1402981111.
  42. Rasid O, Meulenbroeks C, Gröne A, Zaiss D, Sijts A. Enhanced inflammatory potential of CD4+ T cells that lack proteasome immunosubunit expression in a T-cell transfer-based colitis model. Plos One (2014); (4):e95378 doi: 10.1371/journal.pone.0095378.
  43. Rossi A, Michelini Z, Leone P, Borghi M, Blasi M, Bona R, Spada M, Grasso F, Gugliotta A, Klotman ME, Cara A, Negri D. Optimization of mucosal responses after intramuscular immunization with integrase defective lentiviral vector. PLoS One (2014); 9(9):e107377,2014. Doi:10.1371/journal.pone.0107377.
  44. Sciaraffia, E; Riccomi, A; Lindstedt, R; Gesa, V; Cirelli, E; Patrizio, M; De Magistris, MT; Vendetti, S. Human monocytes respond to extracellular cAMP through A2A and A2B adenosine receptors. Journal of Leucocyte Biology (2014) doi:10.1189/jlb.3A0513-302RR
  45. John S. Tregoning, Ekaterina Kinnear. Using Plasmids as DNA Vaccines for Infectious Diseases. Microbiol Spectr. (2014) doi: 10.1128/microbiolspec
  46. van der Vaart M et al. The DNA Damage-Regulated Autophagy Modulator DRAM1 Links Mycobacterial Recognition via TLR-MYD88 to Autophagic Defense. Cell Host and Microbe (2014) doi: 10.1016/j.chom.2014.05.005.
  47. van Ulsen P, Rahman Su, Jong WS, Daleke-Schermerhorn MH, Luirink J. Type V secretion: from biogenesis to biotechnology. Biochimica et Biophys Acta (2014); 1843(8):1592-611. doi: 10.1016/j.bbamcr.2013.11.006.
  48. Vogelzang A, et al. Central memory CD4+ T cells are responsible for the recombinant bacillus calmette-guérin ΔureC::hly vaccine’s superior protection against Tuberculosis. Journal of Infectious Diseases (2014) ; 210(12):1928-37. doi: 10.1093/infdis/jiu347.
  49. Walzl G. Clinical immunology and multiplex biomarkers of human tuberculosis Cold Spring Harbor Perspectives in Medicine (2014) December;5(4). pii: a018515. doi: 10.1101/cshperspect.a018515.
  50. Weiner J, Kaufmann SH. Recent advances towards tuberculosis control: vaccines and biomarkers. Journal of Internal Medicine (2014); 275(5):467-80. doi: 10.1111/joim.12212.
  51. Zhang Xet al. Plasmacytoid DC engagement by Flu vaccine as a surrogate strategy for driving Th1 responses in human neonatal settings. Journal of Infectious Diseases (2014); doi: 10.1093/infdis/jiu103.
  52. Zhang X. et al. CD4 T Cells with Effector Memory Phenotype and Function Develop in the Sterile Environment of the Fetus. Science Translational Medicine (2014) ; 6, 238ra72; DOI: 10.1126/scitranslmed.3008.

Publications 2013

  1. Bardelli M, Alleri L, Angiolini F, Buricchi F, Tavarini S, et al. Ex Vivo analysis of human memory B lymphocytes specific for A and B influenza hemagglutinin by polychromatic flow-cytometry. PLoS One (2013); 8(8): e70620. doi:10.1371/journal.pone.0070620.
  2. Boer, MC., et al, CD39 is involved in mediating suppression by Mycobacterium bovis BCG-activated human CD8+CD39+ regulatory T cells. European Journal of Immunology (2013) May; DOI: 10.1002/eji.201243286.
  3. Boraschi D., Aguado T.M., Dutel C., Goronzy J., Louis J., Grubeck-Loebenstein B., Rappuoli R., Del Giudice G. The gracefully aging immune system. Science Translational Medicine (2013) May; 185:185ps8; doi:10.1126/scitranslmed.3005624.
  4. Calabro, S, Tritto, E, Pezzotti, A, Taccone, M, Muzzi, A, Bertholet, S De Gregorio, E O’Hagand, D T, Baudner, B, Seubert, A. The adjuvant effect of MF59 is due to the oil-in-water emulsion formulation, none of the individual components induce a comparable adjuvant effect. Vaccine (2013) May doi: 10.1016/j.vaccine.2013.05.007.
  5. Ciabattini A, E Pettini and D Medaglini, CD4+ T cell priming as biomarker to study immune response to Preventive Vaccines. Frontiers of Immunology (2013); 4:421. doi: 10.3389/fimmu.2013.00421.
  6. de Paus RA, et al. The influence of influenza virus infections on the development of tuberculosis. Tuberculosis (Edinb). (2013); 93 (3):338-42; doi: 10.1016/j.tube.2013.02.006. Epub 2013 Mar 7.
  7. Dong, H et al. Induction of protective immunity against Mycobacterium tuberculosis by delivery of ESX antigens into airway dendritic cells. Mucosal Immunology (2013) May;6(3):522-34. doi: 10.1038/mi.2012.92. Epub 2012 Oct 3
  8. Dorhoi A, et al. MicroRNA-223 controls susceptibility to tuberculosis by regulating lung neutrophil recruitment. The Journal of Clinical Investigation (2013);123(11):4836-48.
  9. Fiorino, F., Pettini, E., Pozzi, G., Medaglini,D. and Ciabattini, A., Prime-boost strategies in mucosal immunization affect local IgA production and the type of Th response. Frontiers of Immunology (2013) May ; 4: 128 doi: 10.3389/fimmu.2013.00128.
  10. Galdiero MR et al. Tumor associated macrophages and neutrophils in cancer. Immunobiology (2013) November; 218(11):1402-10. doi: 10.1016/j.imbio.2013.06.003.
  11. Garlanda C, Dinarello CA , The interleukin-1 family: back to the future. (2013) December;39(6):1003-18. doi: 10.1016/j.immuni.2013.11.010.
  12. Guenounou S, Bosquet N, Dembek C. J., Le Grand R. and Cosma A. OMIP-016: Characterization of antigen-responsive macaque and human T-cells. Cytometry A (2013) February; 83A:182–184. doi: 10.1002/cyto.a.22233.
  13. Inforzato A, et al. PTX3 as a paradigm for the interaction of pentraxins with the Complement system. Seminars in Immunology (2013); doi: 10.1016/j.smim.2013.05.002.
  14. Inforzato A, Reading PC, Barbati E, Bottazzi B, Garlanda C and Mantovani A. The“sweet”side of a long pentraxin: how glycosylation affects PTX3 functions in innate immunity and inflammation. Frontiers of Immunology (2013); 3:407. doi: 10.3389/fimmu.2012.00407.
  15. Jaillon S, Galdiero MR, Del Prete D, Cassatella MA, Garlanda C, Mantovani A. Neutrophils in innate and adaptive immunity. Seminars in Immunopathology (2013), Volume 35, Issue 4, pp 377-394 DOI 10.1007/s00281-013-0374-8.
  16. Jaillon S et al. Prototypic long pentraxin PTX3 is present in breast milk, spreads in tissues, and protects neonate mice from Pseudomonas aeruginosa lung infection. Journal of Immunology (2013) August;191(4):1873-82. doi: 10.4049/jimmunol.1201642.
  17. Job ER, Bottazzi B, Gilbertson B, Edenborough KM, Brown LE, et al. Serum Amyloid P is a sialylated glycoprotein inhibitor of Influenza A Viruses. PLoS one (2013); 8(3): e59623. doi:10.1371/journal.pone.0059623 285. Joosten SA, Fletcher HA, Ottenhoff THM. A helicopter perspective on TB biomarkers: pathway and process based analysis of gene expression data provides new insight into TB Pathogenesis. PLoS one (2013) September; 8(9): e73230. doi:10.1371journal.pone.0073230.
  18. Kaufmann, SHE. Tuberculosis vaccines: Time to think about the next generation. Seminars in Immunology (2013) May; doi.org/10.1016/j.smim.2013.04.006.
  19. Kaufmann, S.H.E., A. Dorhoi. Inflammation in tuberculosis: interactions, imbalances and interventions. Current Opinion in Immunology (2013);25(4):441-9. doi: 10.1016/j.coi.2013.05.005.
  20. Lehner T and Wang Y. The role of stress-induced activation of HSP70 in dendritic cells, CD4+ T cell, memory and adjuvanticity. Chapter in book entitled Moonlighting Cell Stress Proteins in Microbial Infections, Heat Shock Proteins (2013); pp 203-221; Ed. B Henderson. Springer Science.
  21. Lindenstrøm T, Knudsen NP, Agger EM, Andersen P. Control of chronic mycobacterium tuberculosis infection by CD4 KLRG1- IL-2-secreting central memory cells. Journal of Immunology (2013);190(12):6311-9. doi: 10.4049/jimmunol.1300248.
  22. Mantovani A and M Locati. Tumor-associated macrophages as a paradigm of macrophage Plasticity, Diversity, and Polarization: Lessons and Open Questions. Arteriosclerosis Thrombosis and Vascular Biology (2013);33:1478-1483 doi:10.1161/ATVBAHA.113.300168.
  23. Mantovani A, Valentino S, Gentile S, Inforzato A, Bottazzi B, Garlanda C. The long pentraxin PTX3: a paradigm for humoral pattern recognition molecules. New York Academy of Sciences (2013); 1285:1-14; doi: 10.1111/nyas.12043. Epub 2013 Mar 25.
  24. McElhaney J.E., Coler R.N., Baldwin S.L. Immunologic correlates of protection and potential role for adjuvants to improve influenza vaccines in older adults. Expert Review Vaccines (2013) July; 12(7), 759-766 (2013); doi: 10.1586/14760584.2013.811193.
  25. Pavot. V, Charlotte Primard, Bernard Verrier et al., Encapsulation of Nod1 and Nod2 receptor ligands into poly(lactic acid) nanoparticles potentiates their immune properties. Journal of Controlled Release (2013); 167 ( 1) 60–67 doi.org/10.1016/j.jconrel.2013.01.015.
  26. Pettini E, Prota G, Ciabattini A, Boianelli A, Fiorino F, Pozzi G, Vicino A, Medaglini D. Vaginal immunization to elicit primary T-cell activation and dissemination. PLoS One (2013); 8(12):e80545. doi: 10.1371/journal.pone.0080545.
  27. Saletti G., Çuburu N., Seung Yang J., Dey A., Czerkinsky C., Enzyme-linked immunospot assays for direct ex vivo measurement of vaccine-induced human humoral immune responses in blood. Nature Protocols (2013);8(6):1073-87. doi: 10.1038/nprot.2013.058.
  28. Spensieri F, Borgogni E, Zedda L, Bardelli M, Buricchi F, Volpini G, Fragapane E, Tavarini S, Finco O, Rappuoli R, Del Giudice G, Galli G, Castellino F. Human circulating influenza-CD4+ ICOS1+IL-21+ T cells expand after vaccination, exert helper function, and predict antibody responses. Proceedings of National Academy of Sciences U S A PNAS (2013); 110(35):14330-5. doi: 10.1073/pnas.1311998110.
  29. van Laarhoven A., Mandemakers J., Kleinnijenhuis J., Enaimi M., Lachmandas E., Joosten L., Ottenhoff T., Netea M., van Soolingen D. and van Crevel R. Low induction of proinflammatory cytokines evolutionary success of modern strains within the mycobacterium tuberculosis Beijing genotype. Infection and Immunity. (2013):10 3750-3756; published ahead of print 29 July 2013, doi.org/10.1128/IAI.00282-13.
  30. Venereau E, Schiraldi M, Uguccioni M, Bianchi ME. HMGB1 and leukocyte migration during trauma and sterile inflammation. Molecular Immunology (2013);55(1):76-82. doi:10.1016/j.molimm.2012.10.037.
  31. Vono M, Taccone M, Caccin P, Gallotta M, Donvito G, Falzoni S, Palmieri E, Pallaoro M, Rappuoli R, Di Virgilio F, De Gregorio E, Montecucco C, Seubert A. The adjuvant MF59 induces ATP release from muscle that potentiates response to vaccination. Proceedings of National Academy of Sciences U S A PNAS (2013);110(52):21095-100. doi: 10.1073/pnas.1319784110.
  32. Weinberger B, Schirmer M, Matteucci Gothe R, Siebert U, Fuchs D, Grubeck-Loebenstein B. Recall responses to tetanus and diphtheria vaccination are frequently insufficient in elderly persons. Plos One (2013); 8(12): e8296. doi: 10.1371/journal.pone.0082967.
  33. Weiner, J, Maertzdorf J. Kaufmann S. The dual role of biomarkers for understanding basic principles and devising novel intervention strategies in tuberculosis. New York Academy of Sciences. (2013) April; 1283: 22-29. doi: 10.1111/j.1749-6632.2012.06802.x.

Publications 2012

  1. Doni A et al, Mantovani A. Interactions of the humoral pattern recognition molecule PTX3 with the complement system. Immunobiology (2012); 217(11):1122-8.doi: 10.1016/j.imbio.2012.07.004.
  2. Dormitzer P et al, Rappuoli R. Structural vaccinology starts to deliver. Nature Reviews Microbiology (2012) ; (12), 807-813 December 2012 doi:10.1038/nrmicro2893.
  3. Farinacci, M., S. Weber, S.H.E. Kaufmann. The recombinant tuberculosis vaccine rBCG ΔureC::hly+ induces apoptotic vescicles for improved priming of CD4+ and CD8+ T cells. Vaccine (2012); 30: 7608-7614 doi:10.1016/j.vaccine.2012.10.031.
  4. Jong et al. A structurally informed autotransporter platform for efficient heterologous protein secretion and display. Microbial Cell Factories (2012);11:85. doi: 10.1186/1475-2859-11-85.
  5. Kaufmann, S.H.E. Tuberculosis vaccine development: strength lies in tenacity. Trends in Immunology (2012); 33(7):373-9. doi: 10.1016/j.it.2012.03.004.
  6. Kaufmann, SHE and Gengenbacher M., Recombinant live vaccine candidates against tuberculosis. Current Opinion in Biotechnology (2012); 23(6):900-7. doi: 10.1016/j.copbio.2012.03.007.
  7. Maertzdorf, J et al. Enabling biomarkers for tuberculosis control. The International Journal of Tuberculosis and Lung Disease (2012) September;16(9):1140-8. doi: 10.5588/ijtld.12.0246.
  8. Maertzdorf, J et al. Common Patterns and disease-related signatures in tuberculosis and sarcoidosis. Proceedings of National Academy of Sciences USA PNAS (2012); 109(20):7853-8. doi: 10.1073/pnas.1121072109.
  9. Negri DR, et al. Simian immunodeficiency virus-Vpx for improving integrase defective lentiviral vector-based vaccines. Retrovirology (2012) doi: 10.1186/1742-4690-9-69.
  10. Ottenhoff TH et al. Genome-wide expression profiling identifies type 1 interferon response pathways in active tuberculosis. PLoS One (2012) doi: 10.1371/journal.pone.0045839.
  11. Ottenhoff TH. New pathways of protective and pathological host defence to mycobacteria. Trends in Microbiology (2012) September; 20(9):419-28. doi: 10.1016/j.tim.2012.06.00.
  12. Ottenhoff, T. H. M. The knowns and unknowns of the immunopathogenesis of tuberculosis [State of the art]. The International Journal of Tuberculosis and Lung Disease, Volume 16,Number 11, (2012) November , pp. 1424-1432 doi.org/10.5588/ijtld.12.0479.
  13. Ottenhoff T H.M. and Kaufmann S.H.E., State of the art in vaccine development against TB. European Respiratory Society Monograph, Vol. 58. 2012. P.59-71 (2012). doi:10.1183/1025448x.10015912
  14. Rappuoli R., Medaglini D., ADITEC: Joining Forces for Next-Generation Vaccines. Science Translational Medicine (2012) April; 4(128):128cm4. doi: 10.1126/scitranslmed.3003826.
  15. Schiraldi M. et al,. HMGB1 promotes recruitment of inflammatory cells to damaged tissues by forming a complex with CXCL12 and signaling via CXCR4. Journal of Experimental Medicine. (2012) March; 209(3):551-63. doi: 10.1084/jem.20111739. 317. van den Brand J.M. et al. Comparison of temporal and spatial dynamics of seasonal H3N2, pandemic H1N1 and highly-pathogenic avian H5N1 virus infections in ferrets. PLoS One (2012) August;7(8):e42343. doi:10.1371/journal.pone.0042343.
  16. Venereau E. et al, Uguccioni M. Mutually exclusive redox forms of HMGB1 promote cell recruitment on proinflammatory cytokine release. Journal of Experimental Medicine (2012) August;209(9):1519-28. doi: 10.1084/jem.20120189.
  17. Wang Y. et al., A comparative study of stress-mediated immunological functions with the adjuvanticity of alum. Journal of Biological Chemistry (2012); 287(21):17152-60. doi: 10.1074/jbc.M112.347179.
  18. Wang Y et al. The Role of Innate APOBEC3G and Adaptive AID Immune Responses in HLA-HIV/SIV Immunized SHIV Infected Macaques. Plos One (2012)l; 7(4): e34433 doi: 10.1371/journal.pone.0034433.
  19. Wegmann F. et al. Polyethyleneimine is a potent mucosal adjuvant for viral glycoprotein antigens. Nature Biotechnology (2012); 30(9):883-8; doi:10.1038/nbt.2344.
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