A single amino acid substitution in the hemagglutinin of H3N2 subtype influenza A viruses is associated with resistance to the long pentraxin PTX3 and enhanced virulence in mice.
Job ER, Bottazzi B, Short KR, Deng YM, Mantovani A, Brooks AG, Reading PC.
J Immunol. 2014 Jan 1;192(1):271-81. doi: 10.4049/jimmunol.1301814. Epub 2013 Dec 4.
The interleukin-1 family: back to the future.
Garlanda C, Dinarello CA, Mantovani A.
Immunity. 2013 Dec 12;39(6):1003-18. doi: 10.1016/j.immuni.2013.11.010.
The adjuvant MF59 induces ATP release from muscle that potentiates response to vaccination.
Vono M, Taccone M, Caccin P, Gallotta M, Donvito G, Falzoni S, Palmieri E, Pallaoro M, Rappuoli R, Di Virgilio F, De Gregorio E, Montecucco C, Seubert A.
Proc Natl Acad Sci U S A. 2013 Dec 24;110(52):21095-100. doi: 10.1073/pnas.1319784110. Epub 2013 Dec 9.
CXCL5-secreting pulmonary epithelial cells drive destructive neutrophilic inflammation in tuberculosis
Geraldine Nouailles, Anca Dorhoi, Markus Koch, Jens Zerrahn, January Weiner, 3rd, Kellen C. Faé, Frida Arrey, Stefanie Kuhlmann, Silke Bandermann, Delia Loewe, Hans-Joachim Mollenkopf, Alexis Vogelzang, Catherine Meyer-Schwesinger, Hans-Willi Mittrücker, Gayle McEwen and Stefan H.E. Kaufmann
J Clin Invest. doi:10.1172/JCI72030.
CD4+ T Cell Priming as Biomarker to Study Immune Response to Preventive Vaccines
Annalisa Ciabattini, Elena Pettini, and Donata Medaglini
Front Immunol. 2013; 4: 421, Published online 2013 December 4. doi: 10.3389/fimmu.2013.00421, PMCID: PMC3850413
Tumor-Associated Macrophages as a Paradigm of Macrophage Plasticity, Diversity, and Polarization: Lessons and Open Questions.
Mantovani A and M Locati.
Arterioscler Thromb Vasc Biol (2013) July;33:1478-1483 doi:10.1161/ATVBAHA.113.300168.
Recall Responses to Tetanus and Diphtheria Vaccination Are Frequently Insufficient in Elderly Persons
Birgit Weinberger, Michael Schirmer, Raffaella Matteucci Gothe, Uwe Siebert, Dietmar Fuchs, and Beatrix Grubeck-Loebenstein
PLoS One. 2013; 8(12): e82967. Published online 2013 December 11. doi: 10.1371/journal.pone.0082967
Vaginal Immunization to Elicit Primary T-Cell Activation and Dissemination
Elena Pettini, Gennaro Prota, Annalisa Ciabattini, Alessandro Boianelli, Fabio Fiorino, Gianni Pozzi, Antonio Vicino, Donata Medaglini
December 05, 2013, DOI: 10.1371/journal.pone.0080545
Low Induction of Proinflammatory Cytokines Parallels Evolutionary Success of Modern Strains within the Mycobacterium tuberculosis Beijing Genotype.
van Laarhoven A, Mandemakers JJ, Kleinnijenhuis J, Enaimi M, Lachmandas E, Joosten LA, Ottenhoff TH, Netea MG, van Soolingen D, van Crevel R.
Infect Immun. 2013 Oct;81(10):3750-6. doi: 10.1128/IAI.00282-13. Epub 2013 Jul 29.
Ex vivo analysis of human memory B lymphocytes specific for a and B influenza hemagglutinin by polychromatic flow-cytometry.
Bardelli M, Alleri L, Angiolini F, Buricchi F, Tavarini S, Sammicheli C, Nuti S, Degl’innocenti E, Isnardi I, Fragapane E, Del Giudice G, Castellino F, Galli G.
PLoS One. 2013 Aug 15;8(8):e70620. doi: 10.1371/journal.pone.0070620.
Human circulating influenza-CD4+ ICOS1+IL-21+ T cells expand after vaccination, exert helper function, and predict antibody responses.
Spensieri F, Borgogni E, Zedda L, Bardelli M, Buricchi F, Volpini G, Fragapane E, Tavarini S, Finco O, Rappuoli R, Del Giudice G, Galli G, Castellino F.
Proc Natl Acad Sci U S A. 2013 Aug 27;110(35):14330-5. doi: 10.1073/pnas.1311998110. Epub 2013 Aug 12.
MicroRNA-223 controls susceptibility to tuberculosis by regulating lung neutrophil recruitment.
Dorhoi A, Iannaccone M, Farinacci M, Faé KC, Schreiber J, Moura-Alves P, Nouailles G, Mollenkopf HJ, Oberbeck-Müller D, Jörg S, Heinemann E, Hahnke K, Löwe D, Del Nonno F, Goletti D, Capparelli R, Kaufmann SH.
J Clin Invest. 2013 Oct 1. pii: 67604. doi: 10.1172/JCI67604. [Epub ahead of print]
A Helicopter Perspective on TB Biomarkers: Pathway and Process Based Analysis of Gene Expression Data Provides New Insight into TB Pathogenesis
Simone A. Joosten, Helen A. Fletcher, Tom H. M. Ottenhoff
PLoS ONE 8(9): e73230. doi:10.1371/journal.pone.0073230
Immunologic correlates of protection and potential role for adjuvants to improve influenza vaccines in older adults
McElhaney JE, Coler RN, Baldwin SL.
Expert Rev Vaccines. 2013 Jul;12(7):759-66. doi: 10.1586/14760584.2013.811193.
Encapsulation of Nod1 and Nod2 receptor ligands into poly(lactic acid) nanoparticles potentiates their immune properties.
Pavot V, Rochereau N, Primard C, Genin C, Perouzel E, Lioux T, Paul S, Verrier B.
J Control Release. 2013 Apr 10;167(1):60-7. doi: 10.1016/j.jconrel.2013.01.015. Epub 2013 Jan 23.
The “sweet” side of a long pentraxin: how glycosylation affects PTX3 functions in innate immunity and inflammation.
Inforzato A, Reading PC, Barbati E, Bottazzi B, Garlanda C, Mantovani A.
Front Immunol. 2012;3:407. doi: 10.3389/fimmu.2012.00407. Epub 2013 Jan 7.
PTX3 as a paradigm for the interaction of pentraxins with the Complement system.
Inforzato A, Doni A, Barajon I, Leone R, Garlanda C, Bottazzi B, Mantovani A.
Semin Immunol. 2013 Jun 6. pii: S1044-5323(13)00031-6. doi: 10.1016/j.smim.2013.05.002. [Epub ahead of print]
The adjuvant effect of MF59 is due to the oil-in-water emulsion formulation, none of the individual components induce a comparable adjuvant effect.
Calabro S, Tritto E, Pezzotti A, Taccone M, Muzzi A, Bertholet S, De Gregorio E, O’Hagan DT, Baudner B, Seubert A.
Vaccine. 2013 May 16. pii: S0264-410X(13)00563-X. doi: 10.1016/j.vaccine.2013.05.007. [Epub ahead of print]
Tuberculosis vaccines: Time to think about the next generation
Stefan H.E. Kaufmann
Seminars in immunology, 21 May 2013
Serum Amyloid P Is a Sialylated Glycoprotein Inhibitor of Influenza A Viruses.
Job ER, Bottazzi B, Gilbertson B, Edenborough KM, Brown LE, et al. (2013)
PLoS ONE 8(3): e59623. doi:10.1371/journal.pone.0059623
Enzyme-linked immunospot assays for direct ex vivo measurement of vaccine-induced human humoral immune responses in blood
Giulietta Saletti, Nicolas Çuburu, Jae Seung Yang, Ayan Dey & Cecil Czerkinsky
Nature Protocols 8, 1073–1087 (2013) doi:10.1038/nprot.2013.058
Prime-boost strategies in mucosal immunization affect local IgA production and the type of Th response.
Fiorino F, Pettini E, Pozzi G, Medaglini D and Ciabattini A (2013).
Front. Immunol. 4:128. doi: 10.3389/fimmu.2013.00128
The gracefully aging immune system.
Boraschi D., Aguado T.M., Dutel C., Goronzy J., Louis J., Grubeck-Loebenstein B., Rappuoli R., Del Giudice G.
Sci Transl Med 2013;185:185ps8
The influence of influenza virus infections on the development of tuberculosis.
de Paus RA, van Crevel R, van Beek R, Sahiratmadja E, Alisjahbana B, Marzuki S, Rimmelzwaan GF, van Dissel JT, Ottenhoff TH, van de Vosse E.
Tuberculosis (Edinb). 2013 May;93(3):338-42. doi: 10.1016/j.tube.2013.02.006. Epub 2013 Mar 7.
Tumor associated macrophages and neutrophils in cancer.
Galdiero MR, Bonavita E, Barajon I, Garlanda C, Mantovani A, Jaillon S.
Immunobiology. 2013 Nov;218(11):1402-10. doi: 10.1016/j.imbio.2013.06.003. Epub 2013 Jun 17.
OMIP-016: Characterization of antigen-responsive macaque and human T-cells.
Guenounou S, Bosquet N, Dembek CJ, Le Grand R, Cosma A.
Cytometry A. 2013 Feb;83(2):182-4. doi: 10.1002/cyto.a.22233. Epub 2012 Nov 26.
Neutrophils in innate and adaptive immunity.
Jaillon S, Galdiero MR, Del Prete D, Cassatella MA, Garlanda C, Mantovani A.
Semin Immunopathol. 2013 Jul;35(4):377-94. doi: 10.1007/s00281-013-0374-8. Epub 2013 Apr 4.
Prototypic long pentraxin PTX3 is present in breast milk, spreads in tissues, and protects neonate mice from Pseudomonas aeruginosa lung infection.
Jaillon S, Mancuso G, Hamon Y, Beauvillain C, Cotici V, Midiri A, Bottazzi B, Nebuloni M, Garlanda C, Frémaux I, Gauchat JF, Descamps P, Beninati C, Mantovani A, Jeannin P, Delneste Y.
J Immunol. 2013 Aug 15;191(4):1873-82. doi: 10.4049/jimmunol.1201642. Epub 2013 Jul 17.
Inflammation in tuberculosis: interactions, imbalances and interventions.
Kaufmann, S.H.E., A. Dorhoi
(Special issue: Host pathogens) Curr. Opin. Immunol. 25:441–449 2013
The potential mechanism of HSP70-derived stimulating peptide epitope in autoimmune Vitiligo.
Lehner T and Wang Y. 2013.
Sci. Trans. Med. (letter) 5:174.
The role of stress-induced activation of HSP70 in dendritic cells, CD4+ T cell, memory and adjuvanticity.
Lehner T and Wang Y. 2013.
Chapter in book entitled Moonlighting Cell Stress Proteins in Microbial Infections, Heat Shock Proteins. Ed. B Henderson. Springer Science.
The long pentraxin PTX3: a paradigm for humoral pattern recognition molecules.
Mantovani A, Valentino S, Gentile S, Inforzato A, Bottazzi B, Garlanda C.
Ann N Y Acad Sci. 2013 May;1285:1-14. doi: 10.1111/nyas.12043. Epub 2013 Mar 25.
Control of Chronic Mycobacterium tuberculosis Infection by CD4 KLRG1- IL-2-Secreting Central Memory Cells.
Lindenstrøm T, Knudsen NP, Agger EM, Andersen P.
J Immunol. 2013 May 15.
HMGB1 and leukocyte migration during trauma and sterile inflammation.
Venereau E, Schiraldi M, Uguccioni M, Bianchi ME.
Mol Immunol. 2013 Aug;55(1):76-82. doi: 10.1016/j.molimm.2012.10.037. Epub 2012 Dec 1.