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The long pentraxin PTX3 as a key component of humoral innate immunity and a candidate diagnostic for inflammatory diseases.
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Clinical Immunology and Multiplex Biomarkers of Human Tuberculosis.
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The Recombinant BCG ΔureC::hly Vaccine Targets the AIM2 Inflammasome to Induce Autophagy and Inflammation.
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Using Plasmids as DNA Vaccines for Infectious Diseases
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Novel vaccination strategies against tuberculosis.
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CD8+ regulatory T cells, and not CD4+ T cells, dominate suppressive phenotype and function after in vitro live Mycobacterium bovis-BCG activation of human cells.
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PLoS One. 2014 Apr 8;9(4):e94192. doi: 10.1371/journal.pone.0094192. eCollection 2014.
Differences in antibody responses between trivalent inactivated influenza vaccine and live attenuated influenza vaccine correlate with the kinetics and magnitude of interferon signaling in children.
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Loading dendritic cells with PLA-p24 nanoparticles or MVA expressing HIV genes induces HIV-1-specific T cell responses.
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Vaccine. 2014 Oct 29;32(47):6266-76. doi: 10.1016/j.vaccine.2014.09.010. Epub 2014 Sep 19.
Immunogenicity and reactogenicity of vaginal immunization with HIVgp140 in women, eliciting ex vivo inhibition of HIV-1, based on innate and T cell immunity.
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The in vivo expressed Mycobacterium tuberculosis (IVE-TB) antigen Rv2034 induces CD4⁺ T-cells that protect against pulmonary infection in HLA-DR transgenic mice and guinea pigs.
Commandeur S, van den Eeden SJ, Dijkman K, Clark SO, van Meijgaarden KE, Wilson L, Franken KL, Williams A, Christensen D, Ottenhoff TH, Geluk A.
Vaccine. 2014 Jun 17;32(29):3580-8. doi: 10.1016/j.vaccine.2014.05.005. Epub 2014 May 14.
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From empiricism to rational design: a personal perspective of the evolution of vaccine development.
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Nat Rev Immunol. 2014 Jul;14(7):505-14. doi: 10.1038/nri3694. Epub 2014 Jun 13.
Macrophage arginase-1 controls bacterial growth and pathology in hypoxic tuberculosis granulomas.
Duque-Correa MA, Kühl AA, Rodriguez PC, Zedler U, Schommer-Leitner S, Rao M, Weiner J 3rd, Hurwitz R, Qualls JE, Kosmiadi GA, Murray PJ, Kaufmann SH, Reece ST.
Proc Natl Acad Sci U S A. 2014 Sep 23;111(38):E4024-32. doi: 10.1073/pnas.1408839111. Epub 2014 Sep 8.
Designing vaccines for the twenty-first century society.
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An autotransporter display platform for the development of multivalent recombinant bacterial vector vaccines.
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A stable nanoparticulate DDA/MMG formulation acts synergistically with CpG ODN 1826 to enhance the CD4⁺ T-cell response.
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Nanomedicine (Lond). 2014 Dec;9(17):2625-38. doi: 10.2217/nnm.14.197.
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Expression of active murine granulocyte-macrophage colony-stimulating factor in an Escherichia coli cell-free system.
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Vaccine. 2014 Feb 3;32(6):685-92. doi: 10.1016/j.vaccine.2013.11.100. Epub 2013 Dec 21.
Recent progress in HIV vaccines inducing mucosal immune responses.
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Decoration of outer membrane vesicles with multiple antigens by using an autotransporter approach.
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Macrophage- and Neutrophil-Derived TNF-α Instructs Skin Langerhans Cells To Prime Antiviral Immune Responses.
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Optimization of mucosal responses after intramuscular immunization with integrase defective lentiviral vector.
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TRANSVAC workshop on standardisation and harmonisation of analytical platforms for HIV, TB and malaria vaccines: ‘How can big data help?’
Céline Dutruel, Jelle Thole, Mark Geels, Hans-Joachim Mollenkopf, Tom Ottenhoff, Carlos A. Guzman, Helen A. Fletcher, Odile Leroy, Stefan H.E. Kaufmann
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Central Memory CD4+ T Cells Are Responsible for the Recombinant Bacillus Calmette-Guérin ΔureC::hly Vaccine’s Superior Protection Against Tuberculosis.
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The humoral pattern recognition molecule PTX3 is a key component of innate immunity against urinary tract infection.
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Immunity. 2014 Apr 17;40(4):621-32. doi: 10.1016/j.immuni.2014.02.015.
The effect of vaginal immunization in women with HIVgp140 and HSP70 on HIV-1 replication, innate and T cell adaptive immunity
David J. M. Lewis, Yufei Wang, Zhiming Huo, Raphaela Giemza, Kaboutar Babaahmady, Durdana Rahman, Robin J. Shattock, Mahavir Singh and Thomas Lehner
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Innovative strategies to identify M. tuberculosis antigens
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Annemieke Geluk, Krista E. van Meijgaarden, Simone A. Joosten, Susanna Commandeur and Tom H. Ottenhoff
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CD4 T cells with effector memory phenotype and function develop in the sterile environment of the fetus.
Zhang X, Mozeleski B, Lemoine S, Dériaud E, Lim A, Zhivaki D, Azria E, Le Ray C, Roguet G, Launay O, Vanet A, Leclerc C, Lo-Man R.
Sci Transl Med. 2014 May 28;6(238):238ra72. doi: 10.1126/scitranslmed.3008748.
Induction of CD8+ T-cell responses against subunit antigens by the novel cationic liposomal CAF09 adjuvant.
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Plasmacytoid Dendritic Cells Engagement by Influenza Vaccine as a Surrogate Strategy for Driving T-Helper Type 1 Responses in Human Neonatal Settings.
Zhang X, Casartelli N, Lemoine S, Mozeleski B, Azria E, Le Ray C, Schwartz O, Launay O, Leclerc C, Lo-Man R.
J Infect Dis. 2014 Mar 21. [Epub ahead of print]
Progress in tuberculosis vaccine development and host-directed therapies-a state of the art review.
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Lancet Respir Med. 2014 Apr;2(4):301-320. doi: 10.1016/S2213-2600(14)70033-5. Epub 2014 Mar 24.
The BCG replacement vaccine VPM1002: from drawing board to clinical trial.
Kaufmann SH, Cotton MF, Eisele B, Gengenbacher M, Grode L, Hesseling AC, Walzl G.
Expert Rev Vaccines. 2014 May;13(5):619-30. doi: 10.1586/14760584.2014.905746. Epub 2014 Apr 7.
Tuberculosis vaccine development at a divide.
Kaufmann SH.
Curr Opin Pulm Med. 2014 May;20(3):294-300. doi: 10.1097/MCP.0000000000000041.
Recent advances towards tuberculosis control: vaccines and biomarkers (Review).
Weiner 3rd J, Kaufmann SHE Max Planck Institute for Infection Biology, Berlin, Germany.
J Intern Med 2014; 275: 467–480.
Challenges and responses in human vaccine development.
Kaufmann SH, Juliana McElrath M, Lewis DJ, Del Giudice G.
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Reverse translation in tuberculosis: neutrophils provide clues for understanding development of active disease
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Front. Immunol., 05 February 2014 | doi: 10.3389/fimmu.2014.00036
Tuberculosis vaccine with high predicted population coverage and compatibility with modern diagnostics.
Knudsen NP, Nørskov-Lauritsen S, Dolganov GM, Schoolnik GK, Lindenstrøm T, Andersen P, Agger EM, Aagaard C.
Proc Natl Acad Sci U S A. 2014 Jan 6. [Epub ahead of print]