ADITEC, for the first time conducted head to head comparison of vaccine adjuvants: results are published in Nature Scientific Reports


Within the ADITEC project several partners collaborated in comparing different adjuvants that are available within the project. This is the first extensive attempt to categorize clinical-grade adjuvants based on their immune profiles and protective efficacy to inform a rational development of next generation vaccines for human use.  It was published in Nature Scientific Reports on 21st January 2016.

Different human vaccine adjuvants promote distinct antigen-independent immunological signatures tailored to different pathogens
Niels Peter H. Knudsen, Anja Olsen, Cecilia Buonsanti, Frank Follmann, Yuan Zhang, Rhea N. Coler, Christopher B. Fox, Andreas Meinke, Ugo D´Oro, Daniele Casini, Alessandra Bonci, Rolf Billeskov, Ennio De Gregorio, Rino Rappuoli, Ali M. Harandi, Peter Andersen & Else Marie Agger
Nature Scientific Reports 21 January 2016, doi:10.1038/srep19570